A5021720379- Head and Neck Cancer Studies
- Oral health in cancer treatment
- Advanced Radiotherapy Techniques
- Peptidase Inhibition and Analysis
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Ocular Oncology and Treatments
- Head and Neck Surgical Oncology
- Brain Metastases and Treatment
- Medical Imaging Techniques and Applications
- Oral Health Pathology and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Cancer Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- Quality and Safety in Healthcare
- Radiopharmaceutical Chemistry and Applications
- Radiation Therapy and Dosimetry
- Immune Cell Function and Interaction
- Cancer therapeutics and mechanisms
- Phytochemical and Pharmacological Studies
- ATP Synthase and ATPases Research
- Digital Radiography and Breast Imaging
Shanghai Ninth People's Hospital
2011-2024
Shanghai Jiao Tong University
2010-2023
National Clinical Research Center for Digestive Diseases
2021
Southeast University
2009
Southeast University
2009
Background Cyclin D1 (CCND1) has been associated with chemotherapy resistance and poor prognosis. In this study, we tested the hypothesis that CCND1 expression determines response clinical outcomes in locally advanced head neck squamous cell carcinoma (HNSCC) patients treated neoadjuvant followed by surgery radiotherapy. Methodology Findings 224 HNSCC were either cisplatin-based radiotherapy (neoadjuvant group, n = 100) or (non-neoadjuvant 124). was assessed immunohistochemistry. levels...
Abstract Objectives/Hypothesis: Is the severity of acute oral mucositis in patients who receive postoperative intensity‐modulated radiotherapy (PO‐IMRT) for tongue squamous cell carcinoma (SCC) reduced by sparing mucosa outside planning target volume (PTV)? Study Design: Prospective, randomized trial. Methods: Forty‐eight with SCC received PO‐IMRT at our institution were to two groups: oral‐sparing (OR‐SP) group and oral‐unsparing (OR‐USP) group. For OR‐SP (n = 24), PTV was spared....
Abstract Background We compared outcomes and xerostomia grade after postoperative intensity‐modulated radiation therapy (IMRT) conventional radiotherapy (RT) in patients with oral oropharyngeal carcinoma. Methods Eighty‐eight cavity ( n = 77) 11) carcinoma underwent IMRT 44) or RT 44). Outcomes, failure patterns, volume, doses, salivary gland V30, were evaluated. The median follow‐up was 53 months (range, 48–58 months). interval from surgery to 4 weeks 3–6 weeks). Results Twenty‐one (7 14...
Abstract Patients with locally advanced head and neck squamous cell carcinoma (LA‐HNSCC) have poor survival outcomes. The real‐world efficacy of nimotuzumab plus intensity modulated radiotherapy (IMRT)‐based chemoradiotherapy in patients LA‐HNSCC remains unclear. A total 25,442 HNSCC were screened, 612 matched by propensity score matching (PSM) (1:1). PSM was utilized to balance known confounding factors. who completed at least five doses identified as study group. primary end point 3‐year...
This paper introduces the individual design of oral radiotherapy stent based on 3D printing technology, and expounds its principle. The modeling device is CT images Mimics software, which builds a set technology. instrument has more advantage in high precision, fast modeling, individualized production digital storage. results show that construction printed dental feasible, provides new idea method for stents.
The present study was designed to investigate the application of positron images from photonuclear reactions verify location targeted radiation in vivo.The phantom conducted with distilled water, porcine muscle, adipose tissue, and graphite; these subjects were irradiated separately 50 MV photons generated by an MM50 Racetrack Microtron. emission activity measured using a Geiger counter, radioactive decay curves for each materials then established. tomography (PET) three tissue models also...
5593 Background: The role of induction chemotherapy in locally advanced and resectable oral squamous cell carcinoma has not been well issued. Methods: A prospective, open label, parallel, interventional randomized control trail performed to evaluate the TPF protocol (OSCC) patients at clinical stage III IVA. received two cycles (75 mg/m 2 docetaxel d1, 75mg/m cisplatin 750mg/m 5-fluorouracil d1-5) followed by radical surgery post-operative radiotherapy with a dose from 54 66 Gy (the...
To explore the application value of MAR algorithm in metal artifact removal CT simulator.CT phantom with titanium plate was scanned using conventional algorithms and algorithms, respectively. Artifact index(AI), contrast-to-noise ratio(CNR) AI values at different slices were used to analyze images.In index, (10.28±2.60) is significantly lower than (20.65±5.04); In ratio (7.81±1.12) better (5.61±1.36). The above indicators statistically significant both (P<0.01). affected by artifacts, index...
e18006 Background: Head and neck squamous cell carcinoma (HNSCC) is characterized by the high expression of epidermal growth factor receptor (EGFR). Randomized study has demonstrated a survival advantage associated with use EGFR antibody (C225) in conjunction radiation locally advanced HNSCC (LA-HNSCC). However, role plus concurrent chemoradiotherapy (CCRT), especially intensity-modulated radiotherapy (IMRT) era, still controversial. Therefore, we conducted multicenter, retrospective...
Objective To investigate the mechanism of extremely low frequency electromagnetic field (ELF-EMF) and X-ray irradiation on liver carcinoma cell lines BEL-7402. Methods Liver BEL-7402 had been incubated with ELF-EMF (100 Hz, 0.7 mT, 30 min, 3 days) after at different doses (0, 2, 4, 6, 8,10 Gy). The cells were observed morphologic changes scanning electron microscope. Flow cytometry gene microarray used to apeptosis. Results plus induced apoptosis was under microscope.When X-irradiation 8 10...
Objective To investigate the effect of ionizing radiation on expression NKG2D ligand surface oral squamous cell carcinoma line SCC25 and its cytotoxicity to tumor cells. Methods When cells were cultured into logarithmic growth phase, they randomly designed as control (without treatment) experimental group (2 Gy by drawing lots. Flow cytometry was used detect expressions ligands major histocompatibility complex class Ⅰ chain-related molecule (MIC)A, MICB, UL16 binding protein (ULBP)1...
Abstract Objective The spatial location of the orbital lymphoma target area is special; improving quality plan and protecting eye are important focus areas for doctors physicists. This study aimed to investigate dosimetric characteristics Agility grating system in lymphoma. Methods A total 10 patients with who underwent radiotherapy at Ninth People's Hospital, affiliated Shanghai Jiaotong University School Medicine, from 1 May 2016 30 2018 were selected. Monaco treatment planning was used...
To explore the high-risk fault risk of CT simulator and main causes risk, to put forward effective management strategies.The failure mode effect analysis method was used identify control operational simulator.5 major components, 8 models 17 were analyzed. The top 5 are:anode target surface burn caused by direct scanning without warming up tube (590.4), (518.2), burnout joints aging high voltage cables (424.2), motor carbon brush wear (304.8) belt break (296.4).The can effectively equipment...
To establish a set of evaluation system digital radiography clinical value and provide foundation for the maturity assessment radiography.The was established by literature survey,expert consultation,and percentage weight method.The expert authority coefficients were 0.81 0.88,respectively.After two rounds consultation,variation each item ranged from 0 to 0.207,and coefficient coordination 0.599.The index consisted 5 first-level indexes 12 second-level indexes.The weights such as image...
Objective To investigate clinical characteristics and risk factors of brain metastasis in patients with head neck squamous cell carcinoma (HNSCC). Methods From 2010 to 2015, over 18 years age, pathologically confirmed HNSCC at the time diagnosis, were identified using SEER database National Cancer Institute. Incidence survival data calculated. Kaplan-Meier method was used calculate rate. Logistic univariate multivariate analysis analyze correlations between sex, T stage, N stage...
Objective A retrospective review of brain metastases from primary head and neck cancer. Methods A total 38 patients with metastasis confirmed by MRI at Shanghai No.9 People's Hospital 2009 to 2018 were studied. Information on site, pathologic type, stage, performance status, treatments, follow ups collected tabulated for review. Results The identified MRIs a median age 56, male-female ratio 22/16(1∶0.7). Original sites salivary gland(12), palate(6), maxillary sinus & maxilla(5),...