A5101947933- Cancer, Hypoxia, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- RNA modifications and cancer
- Oral and Maxillofacial Pathology
- Salivary Gland Disorders and Functions
- Advanced Proteomics Techniques and Applications
- Head and Neck Surgical Oncology
- Oral Health Pathology and Treatment
- Bone Tumor Diagnosis and Treatments
- Lymphatic System and Diseases
- Oral microbiology and periodontitis research
- RNA Interference and Gene Delivery
- Mass Spectrometry Techniques and Applications
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- Cancer Research and Treatments
- Cleft Lip and Palate Research
- Hepatitis B Virus Studies
- Microbial Metabolism and Applications
- Ear and Head Tumors
- Proteoglycans and glycosaminoglycans research
- Optical Coherence Tomography Applications
- Cancer-related gene regulation
Jiangsu University
2015-2025
Affiliated Hospital of Jiangsu University
2015-2025
Jinzhou Medical University
2023
Nanjing University
2005-2021
Nanjing Medical University
2005-2021
Shanghai Jiao Tong University
2011-2013
Stomatology Hospital
2013
Shanghai Ninth People's Hospital
2011-2012
Shanghai Second People's Hospital
1998
Saliva is a noninvasive biofluid that can contain metabolite signatures of oral squamous cell carcinoma (OSCC). Conductive polymer spray ionization mass spectrometry (CPSI-MS) employed to record wide range species within few seconds, making this technique appealing as point-of-care method for the early detection OSCC. samples from 373 volunteers, 124 who are healthy, have premalignant lesions, and 125 OSCC patients, were collected discovering validating dysregulated metabolites determining...
Objectives: Integrins, the coordinator of extracellular and intracellular signaling, are often found to be aberrant in tumors can reshape tumor microenvironment. Although previous studies showed that integrin beta 2 (ITGB2) is important for host defense, its expression profile role tumors, especially cancer associated fibroblasts (CAFs) still unknown. Methods: Immunofluorescence stain fluorescence activated cell sorting were used analyze ITGB2 oral squamous carcinoma (OSCC). RT-PCR western...
Patients with advanced head and neck squamous cell carcinoma (HNSCC) have a poor prognosis the currently available therapy, tumor recurrence is frequently observed. The discovery of specific membrane-associated cancer stem (CSC) markers crucial for development novel therapeutic strategies to target these CSCs. To address this issue, we established sphere cultures enrich CSCs used them plasma membrane proteomics identify signatures HNSCC spheres. Of dataset that included total 376 identified...
Background Approximately 60–80% of patients with advanced head and neck squamous cell carcinoma (HNSCC) die within five years after diagnosis. Cisplatin-based chemotherapy is the most commonly used palliative treatment for these patients. To evaluate prognostic value X-linked inhibitor apoptosis (XIAP) level as a potential biomarker in patients, we investigated relationship between XIAP expression cisplatin response their prognosis. Methodology/Principal Findings Sixty HNSCC were recruited...
Background Cyclin D1 (CCND1) has been associated with chemotherapy resistance and poor prognosis. In this study, we tested the hypothesis that CCND1 expression determines response clinical outcomes in locally advanced head neck squamous cell carcinoma (HNSCC) patients treated neoadjuvant followed by surgery radiotherapy. Methodology Findings 224 HNSCC were either cisplatin-based radiotherapy (neoadjuvant group, n = 100) or (non-neoadjuvant 124). was assessed immunohistochemistry. levels...
Purpose It is essential to explore potential molecular involved in oral squamous cell carcinoma (OSCC) malignant transformation and progression. The purpose of this study was delineate the amino acids metabolic characteristics OSCC patients test their diagnostic value. Experimental Design Eight pairs matched tumor normal samples were collected for Gas chromatography-mass spectrometry (GC-MS) high throughput untargeted analysis. Another 20 cases (each case including Tumor Normal tissues) also...
Although there is consensus that the optimal safe margin ≥ 5mm, obtaining clear margins (≥5 mm) intraoperatively seems to be major challenge. We applied a molecular diagnostic method at lipidomic level determine surgical resection of OSCC by desorption electrospray ionisation mass spectrometry imaging (DESI-MSI).By overlaying images with hematoxylin-eosin staining (H&E) from 18 recruited participants, spectra all pixels across diagnosed tumour and continuous mucosal regions were extracted...
Histological assessment of resected margins has some drawbacks. We therefore aimed to identify a panel metabolic markers for evaluating the surgical oral squamous cell carcinoma during surgery.A total 28 case OSCC samples were enrolled in study. Gas chromatography-mass spectrometry based untargeted analysis was employed acquire perturbation distance-related development group. The acquired MS data then subjected univariate and multivariate by MetaboAnalyst. Ultra-high performance liquid...
198 Background: The AtezoTRIBE phase II trial reported that adding Atezolizumab to upfront FOLFOXIRI plus Bevacizumab significantly improved overall survival (OS) in patients with metastatic colorectal cancer (mCRC). However, the improvement OS was modest within pMMR/MSS subgroup (HR, 0.80 [80% CI, 0.63–1.02]; P = 0.117) [1]. Cadonilimab, a humanized bispecific antibody targeting both PD-1 and CTLA-4, may offer enhanced therapeutic benefits. Therefore, this study aims investigate whether...
Saliva, which is a critical component of the oral ecosystem, undergoes dynamic changes, particularly during onset and progression periodontitis. This study used Gas Chromatography-Mass Spectrometry (GC-MS), reliable high-throughput tool for metabolomic analysis, to detect salivary metabolic shifts across various stages periodontitis (T1-T4). We compared differential changes in metabolites between HC T1 groups, T2 T3 T4 groups. By analysing saliva samples from 116 individuals-10 healthy...
Dysregulated amino acids metabolism reciprocally interplays with evolutionary phenotypic characteristics of cancer cells to enhance metastasis. The high metastasis potential oral squamous cell carcinoma (OSCC) can manifest perineural invasion (PNI). We here aimed determine the role in OSCCs different PNI statuses. Targeted metabolomics was used quantify 48 20 fresh OSCC samples and 25 were successfully detected, within which 9 significantly up-regulated positive (PNI + ) samples. As its...
J Oral Pathol Med (2013) 42 : 140–147 Background: The carcinogenesis mechanism of adenoid cystic carcinoma (ACC) the salivary gland is poorly understood. MicroRNA155 (miRNA155) has been involved in many malignant tumors. present study aims to examine role miRNA155 tumor growth and invasion ACC. Methods: MiRNA155 expression was determined ACC specimens along with normal glands by quantitative PCR. Using ACC‐2 cells as a model for ACC, cell proliferation examined MTT assay after knocking down...
ObjectiveTo clarify the effects on development, position and morphology of permanent successors primary molars affected by apical periodontitis (AP).MethodA total 132 panoramic radiographs children aged from 4 to 10 were screened out a 159 mandibular second with chronic periodontitis(AP)(93 males 66 females) analyzed. The maturation values interpreted scored according Nolla's method compared normal ones'. proportion abnormalities in orientation counted, differences between men women was...
Abstract Aims Different regions of oral squamous cell carcinoma (OSCC) have particular histopathological characteristics, and the individual histological characteristics tumors are poorly understood. Therefore, calculating proportion tumor cells in different that allow assessment prognostic outcomes for OSCC patients would be great clinical significance. Methods Results We established an open‐source software‐based analytic pipeline defines inner invasive front (ITF) pancytokeratin‐stained...
To discover if human colorectal cancer expresses granulocyte colony stimulating factor receptor (G-CSFR) and (G-CSF) plays an important part in the development progression of cancer.Forty two specimens normal mucosa were investigated, taken from colon or rectum group patients. Immunohistochemistry reverse transcription polymerase chain reaction (RT-PCR) technique used to show G-CSFR expression. The relation between expression clinical pathological factors was analysed.Immucohistochemical...
Head and neck cancer ranks as the sixth most prevalent malignancy, constituting 5 % of all cases. Its inconspicuous onset often leads to advanced stage diagnoses, prompting need for early detection enhance patient prognosis. Currently, research into diagnostic markers relies predominantly on genomics, proteomics, transcriptomics, other methods, which, unfortunately, necessitate tumor tissue homogenization, resulting in loss temporal spatial information. Emerging a recent addition omics...
This was a retrospective analysis of the impact expression p53 in dys-plastic surgical margins early oral squamous cell carcinoma (OSCC) (pT1-2, N0).Seventy-two patients with were recruited. Margin characteristics abstracted from pathology report. Expression dysplastic examined immunohistochemical method and correlated clinicopathological parameters clinical outcomes.Patients moderate/severe dysplasia had poor local relapse-free survival (RFS) compared to those mild dysplasia. Thirty-two...
Abstract The survival rate of oral squamous cell carcinoma (OSCC) can be greatly improved if intervention could initiated as early possible. This poses a technical demand for developing sensitive screening and specific in vitro diagnosis method OSCC. Herewith, large cohort consisting 241 healthy contrast (HC) 578 OSCC patients were recruited conducting the rapid metabolic profiling trace volume serum using conductive polymer spray ionization mass spectrometry (CPSI‐MS). Statistical analysis...
Abstract Small molecule inhibitors of apoptosis proteins (IAPs) antagonists, known as Smac mimetics (SMs), activate non-canonical NF-κB and sensitize cancer cells to TNF-induced cell death. SMs are currently in phase III clinical trials for head neck squamous carcinoma (HNSCC) after promising II trials. To explore the utility oral (OSCC), we tested nine human OSCC lines correlated SM sensitivity with both IAP mutation expression levels. cIAP1 protein was shown be higher a predictor poor...