A5100392703- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Ion Transport and Channel Regulation
- Ubiquitin and proteasome pathways
- Gut microbiota and health
- Parkinson's Disease Mechanisms and Treatments
- Neuroendocrine regulation and behavior
- Water Treatment and Disinfection
- Soil Carbon and Nitrogen Dynamics
- Wastewater Treatment and Nitrogen Removal
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics and Neurodevelopmental Disorders
- Cerebrospinal fluid and hydrocephalus
- Barrier Structure and Function Studies
- Protein Kinase Regulation and GTPase Signaling
- Microbial Community Ecology and Physiology
- Diet and metabolism studies
- Cancer, Hypoxia, and Metabolism
- Adsorption and biosorption for pollutant removal
- Cardiac electrophysiology and arrhythmias
- Magnesium in Health and Disease
- Plant Gene Expression Analysis
- Enzyme Production and Characterization
- Environmental Chemistry and Analysis
- Microbial Metabolic Engineering and Bioproduction
University of Exeter
2017-2025
Chongqing Academy of Animal Science
2022-2025
Shanghai Institute of Organic Chemistry
2022-2025
Chinese Academy of Sciences
2007-2025
Johns Hopkins University
2024-2025
First Affiliated Hospital of Zhengzhou University
2021-2025
Institute of Plant Protection
2013-2025
Tianjin Medical University
2019-2025
Shandong University
2024-2025
The First Affiliated Hospital, Sun Yat-sen University
2025
Scientific Report26 June 2015Open Access Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation Agne Kazlauskaite MRC Protein Phosphorylation Ubiquitylation Unit, College of Life Sciences, University Dundee, UK Search more papers by this author R Julio Martínez-Torres Scott Wilkie Division Biological Chemistry Drug Discovery, Atul Kumar Julien Peltier Alba Gonzalez Clare Johnson Jinwei Zhang Anthony G Hope Mark Peggie Matthias...
Precise homoeostasis of the intracellular concentration Cl- is achieved via co-ordinated activities influx and efflux. We demonstrate that WNK (WNK lysine-deficient protein kinase)-activated SPAK (SPS1-related proline/alanine-rich kinase)/OSR1 (oxidative stress-responsive kinase 1) known to directly phosphorylate stimulate N[K]CCs (Na+-K+ ion co-transporters), also promote inhibition KCCs (K+-Cl- co-transporters) by phosphorylating a recently described C-terminal threonine residue conserved...
Touch control intention recognition is an important direction for the future development of human-machine interactions (HMIs). However, implementation parallel-sensing functional modules generally requires a combination different logical blocks and circuits, which results in regional redundancy, redundant data, low efficiency. Here, location-and-pressure intelligent tactile sensor (LPI sensor) unprecedentedly combined with sensing, computing, logic proposed, enabling efficient...
Activation of Cl(-)-permeable γ-aminobutyric acid type A (GABAA) receptors elicits synaptic inhibition in mature neurons but excitation immature neurons. This developmental "switch" the GABA function depends on a postnatal decrease intraneuronal Cl(-) concentration mediated by KCC2, Cl(-)-extruding K(+)-Cl(-) cotransporter. We showed that serine-threonine kinase WNK1 [with no lysine (K)] forms physical complex with KCC2 developing mouse brain. Dominant-negative mutation, genetic depletion,...
Activating mutations in leucine-rich repeat kinase 2 (LRRK2) are present a subset of Parkinson's disease (PD) patients and may represent an attractive therapeutic target. Here we report 2-anilino-4-methylamino-5-chloropyrimidine, HG-10-102-01(4) is potent selective inhibitor wild-type LRRK2 the G2019S mutant. Compound 4 substantially inhibits Ser910 Ser935 phosphorylation both mutant at concentration 0.1-0.3 µM cells first compound reported to be capable inhibiting mouse brain following...
Activated carbon (AC) has been shown to remove precursors of halogenated disinfection byproducts. Granular and powdered activated (GAC, PAC) were investigated for their potential adsorb N-nitrosodimethylamine (NDMA) from blends river water effluent a wastewater treatment plant (WWTP). At bench scale, waters exposed lignite or bituminous AC, either as PAC in bottle point experiments GAC rapid small-scale column tests (RSSCTs). NDMA formation (FP) was used surrogate precursor removal. FP...
Omentin-1, a novel adipocytokine mainly expressed in visceral adipose tissue, has been found to inhibit the inflammatory response and improve insulin resistance as well other obesity-related disorders. This study investigated association between omentin-1 expression human epicardial tissue (EAT) coronary atherosclerosis. Serum samples, paired biopsies from EAT subcutaneous (SAT), were obtained patients with without artery disease (CAD, n = 28 NCAD, 12, respectively) during elective cardiac...
The K+-Cl- co-transporter KCC2 (SLC12A5) tunes the efficacy of GABAA receptor-mediated transmission by regulating intraneuronal chloride concentration [Cl-]i. undergoes activity-dependent regulation in both physiological and pathological conditions. synaptic excitation is well documented; however, whether transporter regulated inhibition unknown. Here we report a mechanism receptor (GABAAR)-mediated mature hippocampal neurons. Enhancing GABAAR-mediated confines to plasma membrane, while...
Deletion of exon 9 from Cullin-3 (CUL3, residues 403-459: CUL3(Δ403-459)) causes pseudohypoaldosteronism type IIE (PHA2E), a severe form familial hyperkalaemia and hypertension (FHHt). CUL3 binds the RING protein RBX1 various substrate adaptors to Cullin-RING-ubiquitin-ligase complexes. Bound KLHL3, CUL3-RBX1 ubiquitylates WNK kinases, promoting their ubiquitin-mediated proteasomal degradation. Since kinases activate Na/Cl co-transporters promote salt retention, regulates blood pressure....
Abstract The SLC12A cation-Cl − cotransporters (CCC), including NKCC1 and the KCCs, are important determinants of brain ionic homeostasis. SPAK kinase ( STK39 ) is CCC master regulator, which stimulates influx inhibits KCC-mediated efflux via phosphorylation at conserved, shared motifs. Upregulation SPAK-dependent has been implicated in several neurological diseases. Using a scaffold-hybrid strategy, we develop novel potent selective inhibitor,...
Oxytocin is an important regulator of the social brain. In some animal models autism, notably in Magel2tm1.1Mus-deficient mice, peripheral administration oxytocin infancy improves behaviors until adulthood. However, neither mechanisms responsible for deficits nor by which such has long-term effects are known. Here, we aimed to clarify these oxytocin-dependent mechanisms, focusing on memory performance. Using situ hybridization (RNAscope), have established that Magel2 and receptor...
Exosomes derived from hypoxic endometrial epithelial cells are pivotal in cellular communication and tissue repair, offering new perspectives on reproductive health. This manuscript highlights the study by Zhang et al, which investigates effects of miR-214-5p miR-21-5p cell-derived exosomes human umbilical cord mesenchymal stem cells. The reveals that low levels these microRNAs activate signal transducer activator transcription 3 signaling pathway, enhancing cell migration differentiation....
Brief ischemic episodes confer marked protection against myocardial stunning 1-3 d later (late preconditioning [PC] stunning). The mechanism of this powerful protective effect is poorly understood. Although protein kinase C (PKC) has been implicated in PC infarction, it unknown whether triggers late stunning. In addition, the entire PKC hypothesis remains controversial, possibly because effects inhibitors on have not correlated with their activity and/or translocation vivo. Thus, conscious...
N-Nitrosodimethylamine (NDMA) is a probable human carcinogen that forms in drinking water as disinfection byproduct. Several specific precursor chemicals present during chloramination are known but cannot account for the total observed NDMA formation potential (FP) waters. We discovered pharmaceutical of with high FP using liquid chromatography/quadrupole/time-of-flight mass spectrometry (LC/QTOF-MS) screening procedure. The methadone, which used to mitigate heroin withdrawal symptoms and...