A5036425760- Neuroscience and Neuropharmacology Research
- Sphingolipid Metabolism and Signaling
- Ion channel regulation and function
- Lipid Membrane Structure and Behavior
- Ion Channels and Receptors
- Receptor Mechanisms and Signaling
- Bacterial biofilms and quorum sensing
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- Nicotinic Acetylcholine Receptors Study
- Lipid metabolism and biosynthesis
- Lysosomal Storage Disorders Research
- Bioactive Compounds and Antitumor Agents
- Neurogenesis and neuroplasticity mechanisms
- Electrocatalysts for Energy Conversion
- Plant Stress Responses and Tolerance
- Advanced Photocatalysis Techniques
- Cellular transport and secretion
- Ammonia Synthesis and Nitrogen Reduction
- Genetic and Kidney Cyst Diseases
- Seaweed-derived Bioactive Compounds
- Enterobacteriaceae and Cronobacter Research
- Cardiac electrophysiology and arrhythmias
- Bacterial Identification and Susceptibility Testing
- Renal and related cancers
Nanchang University
2018-2025
Inner Mongolia Medical University
2025
Nanjing University of Science and Technology
2022-2024
Xiangya Hospital Central South University
2024
Central South University
2024
Henan Agricultural University
2024
Shanghai University
2024
Sun Yat-sen University
2013-2023
Hubei University of Medicine
2021-2022
Senshu University
2021
The spectrum of nonalcoholic fatty liver disease (NAFLD) includes steatosis, steatohepatitis (NASH), and cirrhosis. Recognition timely diagnosis these different stages, particularly NASH, is important for both potential reversibility limitation complications. Liver biopsy remains the clinical standard definitive diagnosis. Diagnostic tools minimizing need invasive procedures or that add information to histologic data are in novel management strategies growing epidemic NAFLD. We describe an...
Mutations in the polycystin genes, PKD1 or PKD2, results Autosomal Dominant Polycystic Kidney Disease (ADPKD). Although a genetic basis of ADPKD is established, we lack clear understanding proteins’ functions as ion channels. This question remains unsolved largely because polycystins localize to primary cilium – tiny, antenna-like organelle. Using new mouse model, observe cilia that are abnormally long cells associated with cysts after conditional ablation Pkd1 Pkd2. cultures collecting duct...
Abstract It has been long believed that the FeMoS structure, where Fe is bonded with S, plays a pivotal role as biomimetic catalyst for electrochemical nitrogen (N 2 ) fixation. Nevertheless, structure of to heavier analogues (Se or Te) never explored N electrofixation. Here, we theoretically predict electronic FeMo(Se, composed tri‐coordinated species open shells binding Se, which forms joint electron pool promoting activation. Guided by this interesting prediction, then demonstrate...
Hypervirulent and multidrug resistant Klebsiella pneumoniae strains pose a significant threat to the public health. In present study, 21 carbapenem-resistant K. isolates (CRKP) were determined by string test as hypermucoviscous (HMKP), with prevalence of 15.0% (21/140) among CRKP, 1.1% (21/1838) all isolates. Among them, 7 (33.3%), 1 (4.76%) isolate belonged capsular serotype K20 K2 respectively, while 13 (61.9%, 13/21) weren't successfully typed serotyping. All carbapenemase-producers...
A distinctive syndrome caused by hypermucoviscous Klebsiella pneumoniae (HMKP) including pyogenic liver abscess (PLA) is now becoming a globally emerging disease. In the present study, 22.8% (84/369) of K. clinical isolates associated with various types invasive infections were identified as HMKP, 45.2% PLA. Multivariate regression analysis showed that male patients 41-50 years, PLA, diabetes mellitus, and hypertension independent risk factors for HMKP infections. K2 (42.9%, 36/84) was most...
Activation of Cl(-)-permeable γ-aminobutyric acid type A (GABAA) receptors elicits synaptic inhibition in mature neurons but excitation immature neurons. This developmental "switch" the GABA function depends on a postnatal decrease intraneuronal Cl(-) concentration mediated by KCC2, Cl(-)-extruding K(+)-Cl(-) cotransporter. We showed that serine-threonine kinase WNK1 [with no lysine (K)] forms physical complex with KCC2 developing mouse brain. Dominant-negative mutation, genetic depletion,...
Gaucher disease has recently received wide attention due to the unexpected discovery that it is a genetic risk factor for Parkinson's disease. caused by defective activity of lysosomal enzyme, glucocerebrosidase (GCase; GBA1), resulting in intracellular accumulation glycosphingolipids, glucosylceramide and psychosine. The rare neuronopathic forms GD (nGD) are characterized profound neurological impairment neuronal cell death. We have previously described progression neuropathological changes...
Glutamate is the primary excitatory transmitter in adult brain, acting through synapses on dendritic spines and shafts. Early development, however, when glutamatergic are only beginning to form, nicotinic cholinergic excitation already widespread; it mediated by acetylcholine activating receptors (nAChRs) that generate waves of activity across brain regions. A major class nAChRs contributing at this time a species containing α7 subunits (α7-nAChRs). These highly permeable calcium, influence...
Abstract Members of the transient receptor potential (TRP) ion channels conduct cations into cells. They mediate functions ranging from neuronally mediated hot and cold sensation to intracellular organellar primary ciliary signaling. Here we report a cryo-electron microscopy (cryo-EM) structure TRPC4 in its unliganded (apo) state an overall resolution 3.3 Å. The reveals unique architecture with long pore loop stabilized by disulfide bond. Beyond shared tetrameric six-transmembrane fold,...
Significance Ion channels are pore-forming proteins spanning biological membranes. Transient receptor potential ion a subclass of channel proteins, characterized by nonselective permeability to cations such as sodium, calcium, magnesium, and zinc, little voltage sensitivity; their gating is still an area active investigation. TRPM6 TRPM7 ubiquitously expressed with prominent roles in early embryonic development. Uniquely, these also include kinase domain. The functions correlated proteolytic...
Significance Ion channels are proteins that mediate the flow of ions across cell membranes. Human genetic mutations one type ion channel, called hTRPM4, underlie a form progressive familial heart block. Its distribution among many tissues, however, suggests its functions broad. We have solved atomic structure hTRPM4 to an overall resolution 3.7 Å. The channel is composed four identical subunits surrounding central pore. show path Na + through and point out aspects channel’s internal...
Research reveals the structure of TRPC5 ion channel, a potential drug target kidney disease, depression and anxiety.
Abstract According to the principles of chemical thermodynamics, catalytic activation small molecules (like N 2 in air and CO flue gas) generally exhibits a negative activity dependence on O owning competitive oxygen reduction reaction (ORR). Nevertheless, some catalysts can show positive for electrofixation, an important route produce ammonia under ambient condition. Here we report that (Ni 0.20 Co Fe Mn 0.19 Mo 0.21 ) 3 S 4 catalyst arises from high‐entropy mechanism. Through experimental...
Abstract Sphingolipids are ubiquitous in eukaryotic organisms and significant components foods. It has been reported that treatment with sphingolipids prevents colon cancer, improves skin barrier function suppresses inflammatory responses. However, the mechanisms for those effects of dietary not well understood. In this study, to investigate glucosylceramide (GluCer) sphingomyelin (SM) on function, we characterized recovery change sphingolipid metabolism‐related enzymes epidermis using a...
Highlights•Gaucher disease displays considerable phenotypic variability•Genetic variation of mouse strains is used to map Gaucher modifier genes•A combination genotypes predicts the severity disease•An antagonist NMDA receptor increases lifespan GD miceSummaryDiseases caused by single-gene mutations can display substantial variability, which may be due genetic, environmental, or epigenetic modifiers. Here, we induce (GD), a rare inherited metabolic disorder, injecting 15 inbred with low dose...
Despite its importance for γ-aminobutyric acid (GABA) inhibition and involvement in neurodevelopmental disease, the regulatory mechanisms of K+/Cl- cotransporter KCC2 (encoded by SLC12A5) during maturation central nervous system (CNS) are not entirely understood. Here, we applied quantitative phosphoproteomics to systematically map sites phosphorylation CNS development mouse. at Thr906 Thr1007, which inhibits activity, underwent dephosphorylation parallel with GABA excitatory-inhibitory...
Radiation-induced brain injury (RIBI) is a debilitating sequela after radiotherapy to treat head and neck cancer, 20 30% of patients with RIBI fail respond or have contraindications the first-line treatments bevacizumab corticosteroids. Here, we reported Simon's minmax two-stage, single-arm, phase 2 clinical trial (NCT03208413) assess efficacy thalidomide in who were unresponsive had corticosteroid therapies. The met its primary endpoint, 27 58 enrolled showing ≥25% reduction volume cerebral...
Sphingolipids are ubiquitous in all eukaryotic organisms. Various physiological functions of dietary sphingolipids, such as preventing colon cancer and improving the skin barrier function, have been recently reported. One common sphingolipids used a foodstuff is glucosylceramide from plant sources, which composed sphingoid bases distinct those mammals. However, fate derived plants still not understood. In this study, we investigated absorption maize rat intestine using lipid assay lymph...
Glutamatergic synapses are located mostly on dendritic spines in the adult nervous system. The serve as postsynaptic compartments, containing components that mediate and control synaptic signal. Early development, when glutamatergic initially forming, waves of excitatory activity pass through many parts system driven part by a class heteropentameric β2-containing nicotinic acetylcholine receptors (β2*-nAChRs). These β2*-nAChRs widely distributed and, activated, can depolarize membrane...
Resveratrol is a natural phytoalexin. In recent studies, it has been shown to have beneficial effects on cardiovascular disease and cancer deemed effective antiviral immunomodulatory activities. Methicillin-resistant Staphylococcus aureus multidrug-resistant pathogen associated with skin soft tissue infections. Alpha-hemolysin known play key role in the symptoms caused by S. aureus, saeRS two-component system be major regulatory of virulence. The present study was designed determine effect...