A5039059485- Sepsis Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
- Pancreatitis Pathology and Treatment
- Acute Kidney Injury Research
- Immune Response and Inflammation
- Liver Disease Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Pancreatic and Hepatic Oncology Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Tuberculosis Research and Epidemiology
- Chronic Kidney Disease and Diabetes
- Hemodynamic Monitoring and Therapy
- Inflammation biomarkers and pathways
- Dialysis and Renal Disease Management
- COVID-19 diagnosis using AI
- COVID-19 Clinical Research Studies
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Magnetic properties of thin films
- Inflammatory Biomarkers in Disease Prognosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Bacterial biofilms and quorum sensing
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Wound Healing and Treatments
- Blood Coagulation and Thrombosis Mechanisms
Wenzhou University
2020-2025
Wenzhou Medical University
2016-2025
First Affiliated Hospital of Wenzhou Medical University
2016-2025
Zhejiang Hospital
2022-2025
Zhejiang Medicine (China)
2025
China University of Mining and Technology
2025
Zhejiang Lab
2022
Xi'an Conservatory of Music
2022
First Hospital of Jiaxing
2019
GTx (United States)
2018
Abstract Background This study aimed to explore the association between triglyceride-glucose (TyG) index and risk of in-hospital mortality in critically ill patients with sepsis. Methods was a retrospective observational cohort data were obtained from Medical Information Mart for Intensive Care-IV (MIMIC IV2.2) database. The participants grouped into three groups according TyG tertiles. primary outcome all-cause mortality. Multivariable logistics proportional regression analysis restricted...
Hypervirulent and multidrug resistant Klebsiella pneumoniae strains pose a significant threat to the public health. In present study, 21 carbapenem-resistant K. isolates (CRKP) were determined by string test as hypermucoviscous (HMKP), with prevalence of 15.0% (21/140) among CRKP, 1.1% (21/1838) all isolates. Among them, 7 (33.3%), 1 (4.76%) isolate belonged capsular serotype K20 K2 respectively, while 13 (61.9%, 13/21) weren't successfully typed serotyping. All carbapenemase-producers...
Inflammation plays an important role in the initiation and progression of acute kidney injury (AKI). However, evidence regarding prognostic effect platelet-to-lymphocyte ratio (PLR), a novel systemic inflammation marker, among patients with AKI is scarce. In this study, we investigated value PLR predicting outcomes critically ill AKI. Patient data were extracted from Multiparameter Intelligent Monitoring Intensive Care Database III version 1.3. cutoff values determined using smooth curve...
To investigate the association between serum albumin levels within 24 hrs of patient admission and development persistent organ failure in acute pancreatitis.A total 700 patients with pancreatitis were enrolled. Multivariate logistic regression subgroup analysis determined whether decreased was independently associated mortality. The diagnostic performance evaluated by area under Receiver Operating Characteristic (ROC) curves.As decrease, risk significantly increases (Ptrend < 0.001)....
Abstract Uncontrolled hemorrhage is still the most common cause of potentially preventable death after trauma in prehospital settings. However, there rarely are hemostatic materials that can achieve safely and efficiently rapid hemostasis simultaneously. Here, new carbonized cellulose‐based aerogel material developed for management noncompressible torso hemorrhage, intractable issue uncontrolled hemorrhage. The cellulose derived from Agaricus bisporus a series processing, including cutting,...
Abstract Uncontrollable massive bleeding caused by trauma will cause the patient to lose a large amount of blood and drop body temperature quickly, resulting in hemorrhagic shock. This study aims develop hemostatic product for hemorrhage management. In this study, waste pomelo peel as raw material is chosen. It underwent processes carbonization, purification, freeze‐drying. The obtained carbonized (CPP) hydrophilic exhibits porous structure (nearly 80% porosity). water/blood absorption ratio...
Background Long noncoding RNAs (lncRNAs) have been shown to be involved in the development and progression of lung cancer. However, roles lncRNAs cancer are not well understood. Methodology/Principal Findings We used a high-throughput microarray compare lncRNA messenger RNA (mRNA) expression profiles adenocarcinoma normal tissue (NT) samples. Several candidate adenocarcinoma-associated were verified by real-time quantitative reverse transcription polymerase chain reaction (PCR) analysis....
Abstract Acute lung injury (ALI), characterized by inflammatory damage, is a major clinical challenge. Developing specific treatment options for ALI requires the identification of novel targetable signaling pathways. Recent studies reported that endotoxin lipopolysaccharide (LPS) induced TLR4-dependent activation focal adhesion kinase (FAK) in colorectal adenocarcinoma cells, suggesting FAK may be involved LPS-induced responses. Here, we investigated involvement and mechanism mediating...
Background and Aims The aim of this study was to apply machine learning models a nomogram differentiate critically ill from non-critically COVID-19 pneumonia patients. Methods Clinical symptoms signs, laboratory parameters, cytokine profile, immune cellular data 63 patients were retrospectively reviewed. Outcomes followed up until Mar 12, 2020. A logistic regression function (LR model), Random Forest, XGBoost developed. performance these measured by area under receiver operating...
Sepsis is a serious life-threatening disease. Bacterial infection one of the main causes sepsis. Although etiopathogenesis gradually understood, treatment still scarce. Mortality caused by sepsis challenge. Herein, macrophage membrane coated antimicrobial peptide nanoparticles (M−AMPNP) was explored based on specific binding bacterial recognition receptors to bacteria. M−AMPNP used treat infection. In vivo results showed that effectively delivered and retained at site intravenous injection,...
Bacterial infection and scar formation remain primary challenges in wound healing. To address these issues, we developed a decellularized pomelo peel (DPP) functionalized with an adhesive PVA-TSPBA hydrogel antibacterial gallic acid/copper MOFs. The hybrid dressing demonstrates favorable biocompatibility. It does not impede the proliferation of fibroblasts or immune cells can stimulate fibroblast migration, endothelial angiogenesis, M2 macrophage polarization. Additionally, scavenge reactive...
Background and Aims. This study evaluated the prognostic accuracy of BUN for severe acute pancreatitis (SAP) in-hospital mortality (IHM) in terms best timing measurement optimal cutoff points. Methods. determinants at time admission 24 hrs after hospital were recorded analyzed statistically. The ability predicting SAP occurrence IHM assessed using area under receiver-operating characteristic (ROC) curve. Results. For SAP, AUC was 0.75 0.80, respectively. pancreatitis, it 0.86 0.84 admission,...
Abstract Background Sepsis is an infection-induced aggressive and life-threatening organ dysfunction with high morbidity mortality worldwide. Infection-associated inflammation coagulation promote the progression of adverse outcomes in sepsis. Here, we report that phospho-Tyr705 STAT3 (pY-STAT3), not total STAT3, contributes to systemic coagulopathy Methods Cecal ligation puncture (CLP)-induced septic mice were treated BP-1-102, Napabucasin, or vehicle control respectively then assessed for...
Current FDA-approved label recommends that the dosage of polymyxin B should be adjusted according to renal function. However, correlation between pharmacokinetics (PK) and creatinine clearance (CrCL) is poor. This study aimed develop a population PK model in adult patients with various functions identify dosing strategy.A retrospective was performed 32 Nonlinear mixed effects modelling applied build followed by Monte Carlo simulations which designed regimens across function.Polymyxin...
Background: Presently, colistin is commercially available in two different forms, namely, sulfate and its sulphomethylated derivative, colistimethate sodium (CMS). However, the currently reported studies, most of clinical studies on for parenteral use are referred to as CMS. Data pharmacokinetics (PK), efficacy, side effects have not been reported. Methods: This retrospective study was performed carbapenem-resistant organism (CRO)-infected patients treated with more than 72 h. The population...
Sepsis is an aggressive and life-threatening organ dysfunction induced by infection. Excessive inflammation coagulation contribute to the negative outcomes for sepsis, resulting in high morbidity mortality. In this study, we explored whether Eupatilin could alleviate lung injury, reduce during sepsis.We constructed vitro sepsis model stimulating RAW264.7 cells with 1 μg/mL lipopolysaccharide (LPS) 6 hours. The were divided into control group, LPS LPS+ (Eup) Eup group detect their cell...
Low efficiency of targeting and delivery toward the thrombus site poses challenges to using thrombolytic drugs. Inspired by biomimetic system platelet membranes (PMs) glucose oxidase (GOx) modification technologies, we develop a novel GOx-powered Janus nanomotor asymmetrically attaching GOx polymeric nanomotors coated with PMs. Then PM-coated were conjugated urokinase plasminogen activators (uPAs) on their surfaces. The PM-camouflaged design conferred excellent biocompatibility improved...
Abstract Background Recently, production of 16S rRNA methylases by Gram-negative bacilli has emerged as a novel mechanism for high-level resistance to aminoglycosides these organisms in variety geographic locations. Therefore, the spread aminoglycoside determinants become great concern. Methods Between January 2006 and July 2008, 680 distinct Escherichia coli clinical isolates were collected from teaching hospital Wenzhou, China. PCR DNA sequencing used identify methylase extended-spectrum...