A5069247137- Fatty Acid Research and Health
- Liver Disease Diagnosis and Treatment
- Air Quality and Health Impacts
- Nutritional Studies and Diet
- Diet and metabolism studies
- Climate Change and Health Impacts
- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Inflammatory Biomarkers in Disease Prognosis
- Bone health and osteoporosis research
- Ovarian cancer diagnosis and treatment
- Blood Pressure and Hypertension Studies
- Vitamin D Research Studies
- Folate and B Vitamins Research
- Diet, Metabolism, and Disease
- Obesity, Physical Activity, Diet
- Hepatitis B Virus Studies
- Heart Rate Variability and Autonomic Control
- Cancer-related gene regulation
- Health Systems, Economic Evaluations, Quality of Life
Jinan University
2017-2025
Sun Yat-sen University
2014-2024
Huashan Hospital
2022-2024
Fudan University
2013-2024
Fifth Affiliated Hospital of Sun Yat-sen University
2023
University of Jinan
2023
Southern Medical University
2010-2023
Nanfang Hospital
2010-2023
The First Affiliated Hospital, Sun Yat-sen University
2014-2022
Hainan Medical University
2022
This study aimed to determine the levels of health-related behaviours (physical activity, screen exposure and sleep status) among Chinese students from primary, secondary high schools during pandemic COVID-19, as well their changes compared with status before pandemic. A cross-sectional online survey 10,933 was conducted 10 in Guangzhou, China, between 8th 15th March, 2020. After getting informed consent student's caregivers, an questionnaire designed used obtain time spending on 3 months...
Inflammation plays an important role in the initiation and progression of acute kidney injury (AKI). However, evidence regarding prognostic effect platelet-to-lymphocyte ratio (PLR), a novel systemic inflammation marker, among patients with AKI is scarce. In this study, we investigated value PLR predicting outcomes critically ill AKI. Patient data were extracted from Multiparameter Intelligent Monitoring Intensive Care Database III version 1.3. cutoff values determined using smooth curve...
Abstract Coronavirus disease 2019 (COVID-19) is an important and urgent threat to global health. Inflammation factors are for COVID-19 mortality, we aim explore whether the baseline levels of procalcitonin (PCT), C-reaction protein (CRP) neutrophil-to-lymphocyte ratio (NLR) associated with increased risk mortality in patients COVID-19. A retrospective study was conducted a total 76 confirmed were included between January 17, 2020 March 2, 2020, these cases, 17 dead. After adjusting...
Several small studies have suggested that the gut microbiome might influence osteoporosis, but there is little evidence from human metabolomics to explain this association.This study examined association of dysbiosis with osteoporosis and explored potential pathways through which occurs using fecal serum metabolomics.We analyzed composition microbiota by 16S rRNA profiling bone mineral density dual-energy X-ray absorptiometry in 1776 community-based adults. Targeted feces (15 categories) (12...
This study aimed to determine human papillomavirus (HPV) vaccine uptake and willingness receive HPV vaccination among female college students, in China, its associated factors.An online cross-sectional survey of students across the eastern, central, western regions China was undertaken between April September 2019. Partial least squares structural equation modeling (PLS-SEM) used examine factors with vaccine.Among total 4220 who participated this study, 11.0% reported having been vaccinated...
The antibiotic resistance crisis underlies globally increasing failures in treating deadly bacterial infections, largely due to the selection of genes (ARG) collection, known as resistome, human gut microbiota. So far, little is about relationship between resistome and host metabolic disorders such type 2 diabetes (T2D). Here, metagenomic landscape profiled a large multiomics cohort (n = 1210). There significant overall shift structure among healthy, prediabetes, T2D groups. It found that...
Abstract Injury poses heavy burden on public health, accounting for nearly 8% of all deaths globally, but little evidence the role climate change injury exists. We collect data during 2013-2019 in six provinces China to examine effects temperature mortality, and project future mortality attributable driven by based assumption constant population scenario. The results show that a 0.50% (95% confident interval (CI): 0.13%–0.88%) increase risk each 1 °C rise daily temperature, with higher...
Epidemiological evidence on the association of PM2.5 (particulate matter with aerodynamic diameter ≤ 2.5 μm) and its specific components hypertension blood pressure is limited. We applied information participants from World Health Organization's (WHO) Study Global Ageing Adult (SAGE) to estimate associations long-term mass chemical exposure (BP) incidence in Chinese adults ≥ 50 years during 2007–2018. Generalized linear mixed model Cox proportional hazard were investigate effects BP,...
Abstract Background The specific microbiota and associated metabolites linked to non-alcoholic fatty liver disease (NAFLD) are still controversial. Thus, we aimed understand how the core gut impact NAFLD. Methods data for discovery cohort were collected from Guangzhou Nutrition Health Study (GNHS) follow-up conducted between 2014 2018. We 272 metadata points 1546 individuals. input into four interpretable machine learning models identify important with These subsequently applied two...
Abstract Purpose To investigate the expression and clinical significance of insulin-like growth factor 2 mRNA-binding protein family members (IGF2BPs) in pan-cancer evaluate their potential as targets for tumor immunotherapy. Methods Based on data from cancer genome atlas (TCGA) database, analysis was conducted to examine IGF2BPs twenty-two tumors. Results Differential showed high most tissues. Survival mutation analyses suggested that overexpression associated with poor prognosis status...
The self-perception of weight and loss attempts might promote maintenance.To examine trends in current measured body mass index (BMI) weight, self-reported self-perceived status, attempts, strategies among adults the United States.This national cross-sectional study used data from continuous National Health Nutrition Examination Survey (NHANES) sets (1999-2000 to 2015-2016). Participants were US residents older than 20 years. Data analyzed January 2018 December 2018.Current BMI applied...
Ovarian cancer (OC) is a major cause of cancer-related deaths among women. The aim this study was to estimate and report data on the current burden ovarian worldwide over past 30 years.Based provided by GBD 2019, we collected interpreted disease incidence, mortality, disability-adjusted life-years (DALYs), used corresponding age-standardized rates as indicators. Also, categorized attributed risk factors captured due high fasting plasma glucose, occupational exposure asbestos body-mass index,...
Dysbiosis of gut microbiota is associated not only with intestinal disorders but also numerous extraintestinal diseases. Growth hormone-secreting pituitary adenoma (GHPA) an insidious disease persistent hypersecretion GH and IGF-1, causing increased morbidity mortality.
Non-optimal temperatures are associated with mortality risk, yet the heterogeneity of temperature-attributable burden across subnational regions in a country was rarely investigated. We estimated related to non-optimal all provinces China 2019.The global daily temperature data were obtained from ERA5 reanalysis dataset. The and exposure-response curves between for 176 individual causes death Global Burden Disease Study 2019 (GBD 2019). population attributable fraction (PAF) based on curves,...
It remains unclear whether type 2 diabetes and the complication of arthritis are causally related to PM2.5 pollutant. Therefore, we aimed investigate associations long-term exposure with in patients. This study used data from China Health Retirement Longitudinal Survey (CHARLS) implemented during 2011–2018. The were analyzed by Cox proportional hazards regression models, population-attributable fraction (PAF) was calculated assess burden arthritis-attributable PM2.5. A total 21,075...
Background: The Guangzhou Nutrition and Health Study (GNHS) aims to assess the determinants of metabolic disease in nutritional aspects, as well other environmental genetic factors, explore possible biomarkers mechanisms with multi-omics integration.
Metabolic syndrome (MetS) is a complex metabolic disorder with global prevalence of 20%–25%. Early identification and intervention would help minimize the burden on healthcare systems. Here, we measured over 400 proteins from ∼20,000 proteomes using data-independent acquisition mass spectrometry for 7,890 serum samples longitudinal cohort 3,840 participants two follow-up time points 10 years. We then built machine-learning model predicting risk developing MetS within Our model, composed 11...