A5100391174- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Metal-Organic Frameworks: Synthesis and Applications
- Molecular Sensors and Ion Detection
- Plant Pathogens and Fungal Diseases
- Lung Cancer Treatments and Mutations
- Immune cells in cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Plant Physiology and Cultivation Studies
- Spinal Cord Injury Research
- Advanced Nanomaterials in Catalysis
- Escherichia coli research studies
- Cancer Immunotherapy and Biomarkers
- Nanoplatforms for cancer theranostics
- Neuroinflammation and Neurodegeneration Mechanisms
- Gut microbiota and health
- Probiotics and Fermented Foods
- Pesticide Residue Analysis and Safety
- Extracellular vesicles in disease
- Thermochemical Biomass Conversion Processes
- Greenhouse Technology and Climate Control
- Psoriasis: Treatment and Pathogenesis
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Lanthanide and Transition Metal Complexes
Nankai University
2014-2025
Jinan University
2009-2025
Wuhan University
2024-2025
Renmin Hospital of Wuhan University
2025
Boai Hospital of Zhongshan
2024-2025
Nanjing Normal University
2025
Zhongnan Hospital of Wuhan University
2024-2025
Zhuhai People's Hospital
2019-2025
South China Agricultural University
2025
Key Laboratory of Guangdong Province
2025
Natural killer (NK) cells are lymphocytes of the innate immune system that participate in elimination tumor cells. In humans, activating natural cytotoxicity receptors (NCRs) NKp30, NKp44, and NKp46 play a major role NK cell-mediated cell lysis. NKp30 recognizes B7-H6, member B7 family which is expressed on tumor, but not healthy, To understand basis for surveillance by NCRs, we determined structure CD28 includes CTLA-4 PD-1, complex with B7-H6. The overall organization...
Antibiotics have been noted as an important class of emerging contaminants in the environment. Metal-organic frameworks (MOFs), which intensely investigated a novel kind sensing material, tentatively applied to detection antibiotics recent years. In this work, nanoscale MOF (In-sbdc) with strong (quantum yield = 13%) and stable emission water was synthesized. With its effective spectral overlap tetracyclines, adsorption preconcentration usage masking agent, In-sbdc gave sensitive responses...
The differentiation and function of IL-17-producing Th17 cells are tightly regulated by specific transcription factors cytokines, which the key participants in pathogenesis multiple sclerosis (MS) experimental autoimmune encephalomyelitis (EAE). Although miRNAs have been shown to be involved development MS EAE, potential role context Th17-driven autoimmunity is just beginning clarified. miR-20b has reported as a downregulated miRNA blood patients. In this report, it was further studied...
Abstract Coronavirus disease 2019 (COVID-19) is an important and urgent threat to global health. Inflammation factors are for COVID-19 mortality, we aim explore whether the baseline levels of procalcitonin (PCT), C-reaction protein (CRP) neutrophil-to-lymphocyte ratio (NLR) associated with increased risk mortality in patients COVID-19. A retrospective study was conducted a total 76 confirmed were included between January 17, 2020 March 2, 2020, these cases, 17 dead. After adjusting...
Adipose-resident T cells play a crucial role in the development of obesity-induced insulin resistance. However, specific mechanisms, particularly those involving non-immune cytokines, remain unclear. Here, we report significantly elevated levels sclerostin domain-containing protein 1 (SOSTDC1) individuals with type 2 diabetes (T2D), showing positive correlations fasting glucose and HbA1c. cell-specific Sostdc1-deficient mice exhibit resistance to age-induced adipose lipid accumulation...
Herein, a metal-free electrochemical dihydroxylation of unactivated alkenes is described. The transformation proceeds smoothly under mild conditions with broad range alkenes, providing valuable and versatile dihydroxylated products in moderate to good yields without the addition costly transition metals stoichiometric amounts chemical oxidants. Moreover, this method can be applied natural pharmaceutical derivatives, further demonstrating its synthetic utility. Mechanistic studies have...
Abstract The human butyrophilin (BTN) 3 or CD277 molecules belong to the B7 family members and are expressed in various immune cells such as T NK cells. Here, we show that triggering considerably enhances TCR‐induced cytokine production cell proliferation, even when another co‐stimulatory molecule, CD28, is engaged. These CD277‐induced additive functional effects accordance with detection of early T‐cell activation events signaling being increased upon engagement. However, found not involved...
A novel supramolecular ternary polymer mediated by macrocyclic molecules cucurbit[8]uril (CB[8]) and cyclodextrin was successfully constructed, based on the CB[8]-stabilized charge-transfer (CT) interaction cyclodextrin–adamantane host–guest interaction. Herein, we synthesized a naphthol-modified β-cyclodextrin (Np-β-CD) an adamantane–viologen ditopic guest to obtain complex with preorientational donor–acceptor pair. Furthermore, after addition of CB[8] complex, pair naphthol–viologen...
Abstract Metallopolymers combine a processable, versatile organic polymeric skeleton with functional metals, providing multiple functions and methodologies in materials science. Taking advantage of cationic cobaltocenium as the key building block, organogels could be simply switched to hydrogels via highly efficient ion exchange. With unique ionic complexion ability, moieties provide robust soft substrate for recycling antibiotics from water. The essential polyelectrolyte nature offers...
Abstract Construction of simple and efficient protein adsorption materials is extremely vital to satisfy the requirements highly purified proteins in biopharmaceutical biotechnological industries, yet remains challenging. Herein, a cost‐effective strategy develop seaweed‐derived nanofibrous membranes (NFM) for ultrahigh reported. Synergistic regulation by cosolvent ethanol, nonionic surfactants Triton X‐100, polyethylene oxide (PEO 5000k ) employed realize electrospinning sodium alginate...
Cancer immunotherapy has achieved positive clinical responses in the treatment of various cancers, including gastric cancer (GC). In this study, we characterized heterogeneity T cells isolated from GC patients at single-cell level using RNA sequencing.We identified different immune cell subtypes and their heterogeneous transcription factors depicted developmental trajectories.In particular, focused on exhausted CD8 + Tregs discovered that, as compared to control, IRF8 factor was...
Moxibustion, a common therapy in traditional Chinese medicine, has potential benefits for treating decreased ovarian reserve (DOR). The present study investigates the protective effect of moxibustion rat model DOR and explores possible mechanisms.Sixty-four female Sprague-Dawley rats were randomly divided into four groups: control, DOR, (MOX), hormone replacement (HRT). was established by intragastric administration 50 mg/kg Tripterygium glycoside suspension (TGS), once daily 14 days. MOX...
Abstract CD1d-dependent NKT cells have been extensively studied; however, the function of CD8 + NKT-like cells, which are CD1d-independent T with NK markers, remains unknown. Here, we report that express both cell markers (TCRβ and CD3) receptors (NK1.1, CD49b NKG2D), activated significantly expanded in mice immunized GFP-expressing dendritic cells. Distinct from possess a diverse repertoire TCRs secrete high levels IFN-gamma but not IL-4. development is normal CD1d −/− mice, suggests...
The immune response of brain cells to invading bacteria in vivo and the mechanism used by pathogenic escape surveillance remain largely unknown. It is believed that microglia eliminate phagocytosis based on vitro data. Here we find a small percentage engulf neonatal meningitis-causing Escherichia coli (NMEC), but more are activated produce tumor necrosis factor alpha (TNFα), which activates astrocytes secrete complement component 3 (C3) involved anti-bacterial activity. To evade activity...
The conserved diagonal docking mode observed in structures of T-cell receptors (TCRs) bound to peptide–MHC ligands is believed reflect coevolution TCR and MHC genes. This supported by the conservation certain interactions between germ-line–encoded complementarity-determining region (CDR)1 CDR2 loops MHC. However, rules governing these are not straightforward, even when same variable (V) recognizes molecule. Here, we demonstrate that somatically generated CDR3 can markedly alter...
The T cell receptor (TCR)-CD3 complex is composed of a genetically diverse αβ TCR heterodimer associated noncovalently with the invariant CD3 dimers CD3ϵγ, CD3ϵδ, and CD3ζζ. mediates peptide-MHC recognition, whereas molecules transduce activation signals to cell. Although much known about downstream signaling pathways, mechanism whereby engagement by initiates poorly understood. A key solving this problem defining spatial organization TCR-CD3 interactions between its subunits. We have...