A5101796164- Adipose Tissue and Metabolism
- RNA Interference and Gene Delivery
- Adipokines, Inflammation, and Metabolic Diseases
- Virus-based gene therapy research
- Mesenchymal stem cell research
- Reconstructive Surgery and Microvascular Techniques
- Nerve injury and regeneration
- Polysaccharides and Plant Cell Walls
- Body Contouring and Surgery
- Biochemical effects in animals
- Breast Implant and Reconstruction
- Cancer Research and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Wound Healing and Treatments
- Phytochemicals and Antioxidant Activities
- 3D Printing in Biomedical Research
- Lipid metabolism and disorders
- Animal Virus Infections Studies
- Ferroptosis and cancer prognosis
- Heat shock proteins research
- Seaweed-derived Bioactive Compounds
- Cardiovascular Disease and Adiposity
- Reconstructive Facial Surgery Techniques
- RNA modifications and cancer
- Nanoparticle-Based Drug Delivery
First Affiliated Hospital of Chengdu Medical College
2025
China Pharmaceutical University
2025
Peking University Shenzhen Hospital
2024
Nanjing General Hospital of Nanjing Military Command
2024
First Affiliated Hospital of Anhui Medical University
2016-2024
Anhui Medical University
2016-2024
Nanjing University
2024
Sichuan University
2015-2023
State Key Laboratory of Biotherapy
2016-2023
Shanghai Tenth People's Hospital
2022-2023
Synergistic combination therapy of lung cancer using paclitaxel- and triptolide-coloaded lipid-polymer hybrid nanoparticles Jia Liu,* Hao Cheng,* Le Han, Zhun Qiang, Xinwei Zhang, Wei Gao, Kun Zhao, Yangrong Song Department Thoracic Surgery, Tumor Hospital Shaanxi Province, Xi'an, Shaanxi, People's Republic China *These authors contributed equally to this work Purpose: Non-small cell (NSCLC) accounts for the majority cancer. Lipid–polymer (LPNs) combine advantages both polymeric liposomes...
End-to-end neurorrhaphy is the most commonly used method for treating peripheral nerve injury. However, only 50% of patients can regain useful function after with neurorrhaphy. Here, we constructed a 3D-engineered porous conduit to promote recovery transected The that consisted gelatin cryogel was prepared by molding 3D-printed moulds. Due its structure and excellent mechanical properties, this could be collapsed force resumed original shape absorption normal saline. This shape-memory...
Nonalcoholic steatohepatitis (NASH) is the most prevalent cause of chronic liver disease worldwide. Macrophage-mediated inflammation plays a critical role in NASH pathogenesis; however, optimum therapies for macrophage activation and remain elusive. HSPA12A encodes novel member HSP70 family. Here, we report that patients showed increased hepatic expression serum contents. Intriguingly, knockout (Hspa12a-/- ) mice attenuated high-fat diet (HFD)-induced steatosis injury. HFD-induced...
Nanoparticles have promising applications in drug delivery for cancer therapy. Herein, we prepared cationic 1,2-dioleoyl-3-trimethylammonium propane/methoxypoly (ethyleneglycol) (DPP) nanoparticles to deliver doxorubicin (Dox) intravesical therapy of bladder cancer. The DPP micelles a mean dynamic diameter 18.65 nm and zeta potential +19.6 mV. could prolong the residence Dox bladder, enhance penetration into wall, improve cellular uptake Dox. encapsulation by significantly improved...
Clearance of bacteria-secreted toxins can be a benefit to treating bacterial infections. In this study, we show polydiacetylene (PDA) nanoparticle-functionalized microgel for managing topical These functional microgels with designed shapes and size are precisely fabricated via digital light processing (DLP)-based 3D bioprinting process. The PDA nanoparticles that bind neutralize pore-forming (PFTs) installed in the by readily mixing within monomer solution followed printing. PFTs diffuse...
Plasma gel, also known as plasma-rich in growth factors (PRGF) gel or platelet-rich is a novel application of plasma (PRP), created by heating platelet-poor (PPP) to induce denaturation, forming gel-like substance. This then combined with PRP create new injectable biomaterial that offers both the regenerative benefits and structural support due its consistency. has been increasingly used not only for biological properties but cosmetic filler enhance tissue volume improve skin aesthetics. It...
// Xue-Lian Xu 1, * , Hao Cheng 3, Meng-Si Tang 2 Hai-Liang Zhang 1 Rui-Yan Wu Yan Yu Xuan Li Xiu-Min Wang Jia Mai Chen-Lu Yang Lin Jiao Zhi-Ling Zhen-Mei Zhong Rong Deng Jun-Dong Xiao-Feng Zhu State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Center, Sun Yat-sen University, Guangzhou 510060, China Department Gynecological Oncology, University 3 The First Affiliated Hospital Guangdong Pharmaceutical These authors have contributed equally to...
Abstract Oncolytic virus has potential applications in cancer therapy. However, its clinical application is restricted by the virus‐associated biosafety issues. Here, inspired key role of vesicular stomatitis matrix protein (VSVMP) oncolytic (VSV) induced apoptosis, a targeted nanoparticle‐delivered neutral VSVMP gene formulation designed to act like VSV for This consists CRGDKGPDC peptide modified hybrid monomethoxy poly (ethylene glycol)‐poly( d , l ‐lactide) nanoparticles complexed with...
Nanoparticles have great promise for gene delivery. However, the transfection efficiency of nanoparticle-based delivery systems is always unsatisfied to meet requirement effective therapy. Herein, we used low-dosage paclitaxel enhance a nanoscaled system that was self-assembled from N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammoniummethyl sulfate and monomethoxy poly(ethylene glycol)-poly(d,l-lactide) (DPP), creating paclitaxel-encapsulated DPP (P-DPP) nanoparticle. The encapsulated...
Sodium dichloroacetate (DCA) is a mitochondrial pyruvate dehydrogenase kinase inhibitor, and has been shown to display vasoprotective effects in chronic ischemic stroke. The purpose of this study was evaluate the therapeutic effect DCA on vascular dementia (VD) endothelial progenitor cell (EPC)-mediated angiogenesis. After cerebral ischemia-reperfusion rats, administered continuously for 21 days; following which, histological analysis, cognitive functional tests were conducted. Rat bone...