A5100341030- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Sepsis Diagnosis and Treatment
- Traumatic Brain Injury Research
- Endoplasmic Reticulum Stress and Disease
- Liver physiology and pathology
- Adipose Tissue and Metabolism
- Drug Transport and Resistance Mechanisms
- Advanced Glycation End Products research
- Drug-Induced Hepatotoxicity and Protection
- Prostate Cancer Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Sexual Differentiation and Disorders
- MRI in cancer diagnosis
- Diet and metabolism studies
- Pharmacological Effects of Natural Compounds
- Neonatal and fetal brain pathology
- Immune Response and Inflammation
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroblastoma Research and Treatments
- Eosinophilic Disorders and Syndromes
- Urinary Tract Infections Management
- Ultrasound Imaging and Elastography
Second Military Medical University
2009-2025
Nanjing Medical University
2018-2024
Nanjing Drum Tower Hospital
2024
Fujian University of Traditional Chinese Medicine
2023
Hebei Medical University
2022
Third Hospital of Hebei Medical University
2022
Tianjin University of Traditional Chinese Medicine
2021
West China Medical Center of Sichuan University
2019
The First Affiliated Hospital, Sun Yat-sen University
2018
Sun Yat-sen University
2018
Abstract Immunometabolism is critical in the regulation of immunity and inflammation; however, mechanism preventing aberrant activation-induced immunopathology remains largely unclear. Here, we report that glyoxalase II (GLO2) glycolysis branching pathway specifically downregulated by NF-κB signaling during innate immune activation via tristetraprolin (TTP)-mediated mRNA decay. As a result, its substrate S -D-lactoylglutathione (SLG) accumulates cytosol directly induces d -lactyllysine...
Nonalcoholic steatohepatitis (NASH) is the most prevalent cause of chronic liver disease worldwide. Macrophage-mediated inflammation plays a critical role in NASH pathogenesis; however, optimum therapies for macrophage activation and remain elusive. HSPA12A encodes novel member HSP70 family. Here, we report that patients showed increased hepatic expression serum contents. Intriguingly, knockout (Hspa12a-/- ) mice attenuated high-fat diet (HFD)-induced steatosis injury. HFD-induced...
The robustness of plasticity mechanisms during brain development is essential for synaptic formation and has a beneficial outcome after sensory deprivation. However, the role in recovery acute injury children not been well defined. Traumatic (TBI) leading cause death disability among children, long-term from pediatric TBI can be particularly devastating. We investigated altered cortical 2-3 weeks rat model TBI. Significant decreases neurophysiological responses across depth noninjured,...
To observe the effect of metformin on expression SIRT1 and UCP2 in rat liver type 2 diabetes mellitus (T2DM) with nonalcoholic fatty disease (NAFLD), discuss pathogenesis T2DM NAFLD, treatment possible mechanism metformin.Thirty-six male SD rats were randomly divided into a normal control group (group NC, n=12), NAFLD MC, A, n=12). We established model by feeding high-fat high-sugar diet injecting STZ. After success establishment model, was given 300 mg/(kg.d) for 8 weeks. At end experiment,...
Hepatocarcinogenesis is initiated by repeated hepatocyte death and liver damage, the underlying mechanisms mediating cell subsequent carcinogenesis remain to be fully investigated. Immunoresponsive gene 1 (IRG1) its enzymatic metabolite itaconate are known suppress inflammation in myeloid cells, expression parenchymal hepatocytes currently determined. However, potential roles of IRG1 hepatocarcinogenesis still unknown. Here, using diethylnitrosamine (DEN)-induced mouse model, we found that...
Objective To create a nomogram-based model to estimate the Chinese population's 5-year risk of metabolic dysfunction-associated steatotic liver disease (MASLD). Methods We randomly divided 7582 participants into two groups in 7:3 ratio: one group was assigned work with training set, which consisted 5307 cases, and other validate using 2275 cases. The least absolute shrinkage selection operator employed ascertain variables highest correlation among all potential variables. A logistic...
Glycocholic acid (GCA) is a novel identified biomarker for hepatocellular carcinoma (HCC). However, clinical pathological study of GCA has not been extensive due to the limited availability anti-GCA monoclonal antibodies (mAbs) and restricted detection methods. In present study, using human conjugated with bovine serum albumin as immunogen immunize BALB/c mice, mAb was generated characterized. The isotypes heavy chain light were examined be IgG2a κ, respectively, high affinity constant...
To evaluate the therapeutic effect of Ursodeoxycholi acid on treatment liver cirrhosis with hepatitis B.Eighty-four patients were randomly divided into 2 groups:42 to group who given oral capsules combined reduced glutathione,and other 42 control received Yinzhihuang intravenously, glutathione. Therapeutic efficacy,liver function and its normalization rate,and score Child-pugh-Turcotte (CPT)were observed after 4 week 8 treatment.The efficacy had no significant difference between (P>0.05)....
To explore the difference between acoustic radiation force impulse (ARFI) and two-dimensional shearwave elastography (2D-SWE) in grading liver fibrosis (LF).Sixty New Zealand rabbits were divided into control group (n=10; without any treatment) LF (n=50; treated with CCl4 to induce at different degrees). Liver stiffness (LS) measured all animals using ARFI 2D-SWE, tissues same sites collected for pathological analysis. Spearman's rank-correlation coefficient was used analysis LS,and receiver...
Objective To assess the value of biomarkers and somatostatin receptor scintigraphy in diagnosis gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN).Methods 77 GEP-NEN patients were included.The properties tumors determined by immunohistochemistry staining markers Syn CgA.Plasma neuronspecific enolase (NSE) levels measured,and all had 99Tcm-HYNIC-TOC results.Results Immunohistochemistry positive rates CgA 90.4 ％ (66/73) 65.7 (44/67),and former was statistical higher than latter...
Abstract Background Hepatocarcinogenesis is initiated by repeated hepatocyte death and liver damage, the underlying mechanisms mediating cell subsequent carcinogenesis remain to be fully investigated. Immunoresponsive gene 1 (IRG1) its enzymatic metabolite itaconate are known suppress inflammation in myeloid cells, expression parenchymal hepatocytes currently determined. However, potential roles of IRG1 hepatocarcinogenesis still unknown. Methods Hepatocyte-specific knockout mice were...
Introduction: Millions of children and young adults are living with disabilities from traumatic brain injury (TBI) in childhood. Very little is known about age-dependent pathways neuroplasticity on post-injury recovery. Hypothesis: We hypothesized that we could detect deficits neuronal activity after TBI the immature rat using electrophysiology recordings functional magnetic resonance imaging (fMRI). Methods: Rats (P 16-18, n=10) underwent controlled cortical impact (CCI) to left parietal...
Phase Ⅱ metabolic enzymes play pivotal role in the biotransform and metabolism of exogenous substances, which might influence its ability detoxification to carcinogens.Polymorphism have been demonstrated various phase etiology studies showed that individuals exposed same environment could develop different susceptibility tumorigenesis due enzyme polymorphism. Here, we summarized effects polymorphism on risk cancer. Key words: Polymorphism; Gene; Neoplasms; Phase