A5100367066- Peptidase Inhibition and Analysis
- Protease and Inhibitor Mechanisms
- Perovskite Materials and Applications
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Ferroelectric and Piezoelectric Materials
- Advanced Memory and Neural Computing
- Ferroelectric and Negative Capacitance Devices
- Advanced biosensing and bioanalysis techniques
- Organic Light-Emitting Diodes Research
- Organic Electronics and Photovoltaics
- Protein Tyrosine Phosphatases
- DNA and Nucleic Acid Chemistry
- Conducting polymers and applications
- Acoustic Wave Resonator Technologies
- Signaling Pathways in Disease
- Surface Modification and Superhydrophobicity
- Quantum Dots Synthesis And Properties
- Protein Degradation and Inhibitors
- Histone Deacetylase Inhibitors Research
- Neuroscience and Neural Engineering
- Fullerene Chemistry and Applications
- Galectins and Cancer Biology
- Bioactive Compounds and Antitumor Agents
- Peanut Plant Research Studies
Peking University People's Hospital
2025
Peking University
2025
University of Hong Kong
2022-2024
Institute of High Performance Computing
2024
Agency for Science, Technology and Research
2022-2024
Harbin Institute of Technology
2022-2024
Hong Kong University of Science and Technology
2022-2024
Singapore University of Technology and Design
2020-2024
Dongguan University of Technology
2024
Civil Aviation Administration of China
2022
Abstract Immunometabolism is critical in the regulation of immunity and inflammation; however, mechanism preventing aberrant activation-induced immunopathology remains largely unclear. Here, we report that glyoxalase II (GLO2) glycolysis branching pathway specifically downregulated by NF-κB signaling during innate immune activation via tristetraprolin (TTP)-mediated mRNA decay. As a result, its substrate S -D-lactoylglutathione (SLG) accumulates cytosol directly induces d -lactyllysine...
Abstract As a large family of RNA-binding proteins, pentatricopeptide repeat (PPR) proteins mediate multiple aspects RNA metabolism in eukaryotes. Binding to their target single-stranded RNAs (ssRNAs) modular and base-specific fashion, PPR can serve as designable modules for gene manipulation. However, the structural basis nucleotide-specific recognition by designer (dPPR) remains be elucidated. Here, we report four crystal structures dPPR complex with respective ssRNA targets. The repeats...
Mixed-halide perovskite nanocrystals (PeNCs) featuring bandgap-tunable luminescence with narrow bandwidth have emerged as promising electroluminescent materials for light-emitting diodes (LEDs) to satisfy the color standard of Rec. 2100. However, phase segregation mixed-halide perovskites severely restricts spectral stability and lifetime LEDs (PeLEDs). Here, we report that introduction multifunctional side-chain-promoted polymer architectures in synthesis I/Br-mixed PeNCs suppress halide...
The influence of the chemical structure conjugated polymers on nanophase separation and device performance in fullerene-based solar cells has been widely studied, while this is less investigated non-fullerene cells. In work, we design three with different length side chains, find that chains little quantum efficiencies As a comparison, significant effect This indicates morphology blended thin films rather independent donor mechanism for evolution system completely from fullerene system. Our...
Ferroelectric scandium-doped aluminum nitride (Al1-xScxN) is of considerable research interest because its superior ferroelectricity. Studies indicate that Al1-xScxN may suffer from a high leakage current, which can hinder further thickness scaling and long-term reliability. In this work, we systematically investigate the origin current in Al0.7Sc0.3N films via experiments theoretical calculations. The results reveal originate nitrogen vacancies with positively charged states fits well...
Mixed Br/Cl perovskite nanocrystals (PeNCs) exhibit bright pure-blue emission benefiting for fulfilling the Rec. 2100 standard. However, phase segregation remains a significant challenge that severely affects stability and spectrum of light-emitting diodes (PeLEDs). Here, we demonstrate optimization spacing between polydentate functional groups polymer ligands to match surface pattern CsPbBr
Foodborne pathogens such as Clostridium perfringens can cause diverse illnesses and seriously threaten to human health, yet far less attention has been given detecting these pathogenic bacteria. Herein, two morphologies of nanoceria were synthesized via adjusting the concentration NaOH, CeO2 nanorod utilized sensing material achieve sensitive selective detection C. DNA sequence due its strong adsorption ability towards compared nanoparticle. The probe was tightly immobilized on CeO2/chitosan...
On the basis of Bayesian probabilistic inference, Gaussian process (GP) is a powerful machine learning method for nonlinear classification and regression, but has only very limited applications in new areas computational vaccinology immunoinformatics. In current work, we present paradigmatic study using GP regression technique to quantitatively model predict binding affinities over 7000 immunodominant peptide epitopes six types human major histocompatibility complex (MHC) proteins. this...
Abstract Introduction To clarify the expression of caveolin‐1 in human peritoneal vascular endothelial cells (HUM‐CELL‐0116) and investigate whether dialysis fluid (PDF) can promote permeability through caveolae/caveolin‐1‐mediated endocytosis. Methods HUM‐CELL‐0116 were passaged divided into following groups: control group, PDF Filipin DMSO antibody group. The cultured for 0, 4, 12, 24, 48 h. Then, we detected monolayer caveolin‐1. Results (1) Expression caveolin‐1: In decreases after...
In this work, by experiments and material calculations, the steep polarization switching leakage in ferroelectric Al <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.7</inf> Sc xmlns:xlink="http://www.w3.org/1999/xlink">0.3</inf> N are investigated. The calculations suggest that tight distribution of coercive field is attributed to highly uniform with well-aligned domains. electron emission hopping assisted vacancies layer dominate current. For...
Abstract Mixed Br/Cl perovskite nanocrystals (PeNCs) exhibit bright pure‐blue emission benefiting for fulfilling the Rec. 2100 standard. However, phase segregation remains a significant challenge that severely affects stability and spectrum of light‐emitting diodes (PeLEDs). Here, we demonstrate optimization spacing between polydentate functional groups polymer ligands to match surface pattern CsPbBr 1.8 Cl 1.2 PeNCs, resulting in effective synergistic passivation effect improvements PeLED...
Superhydrophobic surfaces have been largely achieved through various surface topographies. Both empirical and numerical simulations reported to help understand design superhydrophobic surfaces. Many such successful also using bioinspired biomimetic designs. Despite this, identifying the right texture meet requirements of specific applications is not a straightforward task. Here, we report hybrid approach that includes experimental methods, simulations, machine learning (ML) algorithms create...
Vascular smooth muscle cell (VSMC) proliferation is a crucial cause of vascular neointima hyperplasia and restenosis, thus limiting the long-term efficacy percutaneous intervention. We explored role wild-type p53-induced phosphatase 1 (Wip1), potent regulator tumorigenesis atherosclerosis, in VSMC hyperplasia.Animal model restenosis was established wild type C57BL/6J VSMC-specific Tuberous Sclerosis (TSC1)-knockdown mice by wire injury. observed increased protein levels Wip1, phospho (p)-S6...
Matrix metalloproteinases (MMPs) play an important role in many physiological and pathological processes. MMP inhibitors have been considered as potential therapeutics for neoplasitc, rheumatic cardiovascular diseases. Our group others developing pyrrolidine scaffold-based a number of years, numerous compounds reported the literature. These can be classified sulfonamide derivatives, proline-containing peptidomimetics acyl derivatives. synthetic show low nanomolar activity some subclasses,...
Controlling polymer film solubility is of fundamental and practical interest typically achieved by synthetically modifying the structure to insert reactive groups. Here, we demonstrate that addition fullerenes or its derivatives (C60 phenyl-C61-butyric acid methyl ester, PCBM) polymers, followed ultraviolet (UV) illumination can change solubility. Contrary most synthetic which dissolve in organic solvents but not water, fullerene-doped films (such as polystyrene) water yet remain stable...
Herein, we report the synthesis and characterization of a series ambipolar cyanostyrylthiophene (CST)-based conjugated polymers without or with fluorine substituents, namely PD-CST, PD-3F-CST, PD-23F-CST, PD-25F-CST. With change number incorporating position substitutes on novel CST unit, electron mobilities field-effect transistors based these dramatically increased from 0.0015 cm2 V–1 s–1 for 0.13 0.25 PD-23F-CST to 0.53 AFM GIXRD investigation indicated that annealed PD-25F-CST thin film...
We designed and synthesized two donor–acceptor type conjugated polymers, the regioirregular polymer RI-PDPP-CNTVT-6 its regioregular counterpart RR-PDPP-CNTVT-6, based on diketopyrrolopyrrole (DPP) alkylated dithienylacrylonitrile (CNTVT) units. Among them, 2-decyltetradecyl side chain DPP acceptor unit hexyl CNTVT donor were used to ensure enough solubility for them. The backbone regioregularity was tune electronic structures carrier transport of system. polymers characterized their...
Previous studies have demonstrated that protein tyrosine phosphatase 1B (PTP1B) can promote tumor progression in breast cancer, colon cancer and prostate cancer. Additionally, PTP1B also acts as a suppressor esophageal lymphoma. These findings suggest functions double-faceted molecule tumors. However, the role of malignant melanoma (MM) is still unknown. expression normal tissues was evaluated by GEO analysis immunohistochemistry. The effects on cell migration invasion were cells with up –...
Surface electromyography (EMG), generated during muscle activities of human beings, allows intuitive control for human-robot interaction to happen. Decoding movement intention from EMG accurately and instantaneously is one the most important parts whole task. Spiking neural network (SNN) with spiking neurons more computationally powerful than networks non-spiking contains temporal information (time-dependency). Compared discrete motion classification task, regression meaningful helpful...