A5039055312- Nutrition and Health in Aging
- Frailty in Older Adults
- Body Composition Measurement Techniques
- Gut microbiota and health
- Cancer Immunotherapy and Biomarkers
- Berberine and alkaloids research
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Gastric Cancer Management and Outcomes
- Ginseng Biological Effects and Applications
- Curcumin's Biomedical Applications
- Nutritional Studies and Diet
- Genomics, phytochemicals, and oxidative stress
- Cancer Risks and Factors
- Cancer Research and Treatments
- Ferroptosis and cancer prognosis
- Cancer survivorship and care
- Colorectal Cancer Surgical Treatments
- Tea Polyphenols and Effects
- Colorectal Cancer Treatments and Studies
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Oral health in cancer treatment
- Diet and metabolism studies
Zhejiang Cancer Hospital
2016-2025
Zhejiang Chinese Medical University
2013-2025
Zhejiang Lab
2025
University of Chinese Academy of Sciences
2019-2024
Guangdong Ocean University
2024
Chinese Academy of Sciences
2020-2023
Cancer Hospital of Chinese Academy of Medical Sciences
2019-2023
Hangzhou Academy of Agricultural Sciences
2017
First Affiliated Hospital Zhejiang University
2007-2011
Abstract Immunometabolism is critical in the regulation of immunity and inflammation; however, mechanism preventing aberrant activation-induced immunopathology remains largely unclear. Here, we report that glyoxalase II (GLO2) glycolysis branching pathway specifically downregulated by NF-κB signaling during innate immune activation via tristetraprolin (TTP)-mediated mRNA decay. As a result, its substrate S -D-lactoylglutathione (SLG) accumulates cytosol directly induces d -lactyllysine...
Tumor invasion and metastasis are closely associated with epithelial‑mesenchymal transition (EMT). EMT refers to epithelial cells under physiological pathological conditions that specific mesenchymal transition. Curcumin inhibits progression via Wnt signaling. The signaling pathway is a conservative EMT‑related involved in the development of various tumors. In present study, MTS assays were employed analyze proliferation curcumin‑treated cells. Naked cuticle homolog 2 (NKD2), chemokine...
Berberine (BBR) is an isoquinoline alkaloid, which has been used in the treatment of intestinal mucositis. However, BBR on chemotherapy-induced mucositis cancer patients remains largely unknown. Here, we investigated effect induced by 5-fluorouracil (5-Fu) using rat model. We detected degree mucosal damage and inflammatory response 5-Fu treated rats with or without administration, changes fecal metabolites gut microbiota 1H NMR spectroscopy 16S rRNA. The mechanism was further explored...
The role of Berberine (BBR) in colorectal cancer (CRC) and gut microbiota has begun to appreciate. However, there was no direct evidence confirm that the regulated by BBR could inhibit CRC. This report investigated effect stool from treated subjects its on CRC.A mouse model for CRC developed using azoxymethane (AOM) dextran sulfate sodium (DSS). Intestinal tissue affected mice were used determine efficacy against Stool samples collected 16s rRNA gene sequencing fecal transplantation (FMT)....
Dietary fat intake is positively associated with elevated risk of colorectal cancer (CRC).Currently, clinical treatments remian inadequate bacause the complex pathogenesis CRC induced by a high-fat diet (HFD).Mechanistically, imbalances in gut microbiota are HFD-associated tumourigenesis.Therefore, we investigated anti-tumor activity berberine (BBR) modulating dysregulated and related metabolites preforming 16S rDNA sequencing liquid chromatography/mass spectrometry.As expected, BBR...
5-Fluorouracil (5-Fu) is a first-line drug for colorectal cancer (CRC) therapy. However, the development of 5-Fu resistance limits its chemotherapeutic effectiveness and often leads to poor prognoses CRC. Transglutaminase 2 (TGM2), member transglutaminase family, considered be associated with chemoresistance through apoptotic prevention in various cancers including TGM2 was found overexpressed two 5-Fu-resistant CRC cell lines down-regulated by increased thiol oxidative stress induced...
Berberine (BBR) has been reported that it effects on inhibiting colorectal cancer (CRC). However, the mechanism of BBR CRC also remains largely unknown. Herein, we investigated therapeutic from perspective gut microbiota and metabolic alterations, which can provide a holistic view to understand CRC. First, AOM/DSS mouse was used as animal model, then degree carcinogenesis in mice with or without administration measured. The composition abundance by using 16S rRNA. Meanwhile, feces samples...
Colorectal cancer is a kind of gastrointestinal tumor with rising morbidity and mortality. 5-fluorouracil one the most effective chemotherapy drugs for treatment CRC. However, clinical data reported dramatic resistance on CRC 5-fluorouracil. Present study aims to explore anti-resistant effect curcumin its mechanism. MTT assay was used evaluate proliferation rHCT-116 cells. Flow cytometry determine apoptosis cell cycle Western Blot performed detect expression level TET1, NKD2, E-cadherin,...
ω-3 polyunsaturated fatty acids (n-3 PUFA), in particular the marine-derived forms eicosapentaenoic acid (EPA) and docosahexaenoic (DHA), have been demonstrated to affect cancer cell replication, cycle death. Epidemiological studies also suggested diets rich n-3 PUFA were inversely correlated with development of cancer. In present study, we explored effects DHA EPA on proliferation activity apoptosis human lung adenocarcinoma line A549. A methyl thiazolyl tetrazolium (MTT) assay was used...
<p class="abstract"><strong>Background:</strong> Malnutrition is common in patients with cancer, which adversely affects the survival and quality of life cancer patients. However, there no national data on prevalence malnutrition Chinese This study aims to evaluate (QOL) local regional, recurrent or metastatic address prognostic value nutritional status QOL China validate patient-generated subjective global assessment (PG-SGA) questionnaire patients.</p><p...
Background. Curcumin is a polyphenol plant-derived compound with anti-inflammatory, antioxidant stress, and anticancer properties that make it have the potential to treat cancer cachexia. However, role of in breast cachexia remains unclear. Methods. The 4T1 cells were subcutaneously injected into BALB/c mice induce After tumor formation, animals divided groups given curcumin or saline interventions. therapeutic effect on was characterized by growth, changes body mass gastrocnemius mass,...
Cdc42, a Rho GTPase family member, is involved in cell transformation, proliferation, survival, invasion and metastasis of human cancer cells. Overexpression Cdc42 has been reported several types cancer. However, the underlying mechanisms are not well understood. The present study showed that was overexpressed 80 110 primary lung patients, overexpression significantly associated with high TNM stage lymph node metastasis. Moreover, RNAi-mediated suppression expression reduced actin filopodia...
Curcumin has been found to exhibit anticancer activity and certain studies have shown that curcumin triggers the apoptosis of human A549 lung adenocarcinoma cells. However, mechanism underlying curcumin‑mediated is not completely understood. The present study was designed investigate effect on induction apoptosis‑related factors in Treatment cells with caused a concentration‑dependent inhibition cell growth an increase apoptosis, as confirmed by THE MTT assay, flow cytometry morphology...
Tumor markers are usually over-expressed in human body fluids during the development of cancers. Monitoring tumor markers' level is thus important for early diagnosis and screening One way to achieve this based on surface enhanced Raman scattering (SERS) technique that can drastically amplify signals analytes a plasmonic metal (e.g., Au, Ag, Cu) surface. However, promising method suffers from aggregation nanoparticles. Here we report stable, reproducible, facile SERS-based readout detect an...
The tripartite motif-containing protein 11 (TRIM11), a member of the TRIM family, has attracted much attention because its involvement in development central nervous system. It gained renewed focus newly found function promoting tumors. However, little is known about role hepatocellular carcinoma (HCC). In present study, we TRIM11 to be overexpressed HCC tissues and cell lines. Downregulation inhibited proliferation invasion vitro vivo as well suppressed epithelial-mesenchymal transition...