A5100430839- Nutrition and Health in Aging
- Inflammatory Biomarkers in Disease Prognosis
- Frailty in Older Adults
- Body Composition Measurement Techniques
- Angiogenesis and VEGF in Cancer
- Cancer Risks and Factors
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
- GDF15 and Related Biomarkers
- Folate and B Vitamins Research
- Inflammation biomarkers and pathways
- Bone and Joint Diseases
- Ion Transport and Channel Regulation
- Soil Carbon and Nitrogen Dynamics
- Gastric Cancer Management and Outcomes
- Renal and related cancers
- Neutropenia and Cancer Infections
- Clay minerals and soil interactions
- Ovarian cancer diagnosis and treatment
- Diet and metabolism studies
- Esophageal and GI Pathology
- Air Quality and Health Impacts
- PARP inhibition in cancer therapy
- Esophageal Cancer Research and Treatment
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Anhui Medical University
2025
Hunan Institute of Mental Health
2024-2025
Hunan University
2024-2025
Beijing Shijitan Hospital
2020-2024
Capital Medical University
2020-2024
Xinqiao Hospital
2020-2024
Army Medical University
2020-2024
Jiangsu Academy of Agricultural Sciences
2024
Guangdong Academy of Medical Sciences
2024
Neuropilin 1 (NRP1) plays an important but ill-defined role in VEGF-A signaling and vascular morphogenesis. We show that mice with a knockin mutation ablates the NRP1 cytoplasmic tail (Nrp1cyto) have normal angiogenesis impaired developmental adult arteriogenesis. The arteriogenic defect was traced to absence of PDZ-dependent interaction between VEGF receptor 2 (VEGFR2) complex synectin, which delayed trafficking endocytosed VEGFR2 from Rab5+ EAA1+ endosomes. This led increased PTPN1...
The role of antithymocyte globulin (ATG) in preventing acute graft-versus-host disease (aGVHD) after HLA-matched sibling donor transplantation (MSDT) is still controversial.We performed a prospective, multicenter, open-label, randomized controlled trial (RCT) across 23 centers China. Patients ages 40-60 years with standard-risk hematologic malignancies an were randomly assigned to ATG group (4.5 mg/kg thymoglobulin plus cyclosporine [CsA], methotrexate [MTX], and mycophenolate mofetil [MMF])...
Although systemic inflammation is an important feature of the cancer cachexia, studies on association between and prognostic cachexia are limited. The objective this study to evaluate whether neutrophil-to-lymphocyte ratio (NLR) associated with outcome quality life for patients investigated any interaction NLR clinical parameters.This a multicentre cohort 2612 suffering from diagnosed June 2012 December 2019. main parameters measured were overall survival (OS) time all-cause mortality....
Abstract Background Despite integrin being highlighted as a stiffness‐sensor molecule in matrix stiffness‐driven angiogenesis, other molecules and their mechanosensory pathways related to angiogenesis hepatocellular carcinoma (HCC) remain obscure. Here, we explored the interplay between Piezo1 β1 pathway effects on HCC better understand stiffness‐induced angiogenesis. Methods The role of was investigated using orthotopic liver cancer SD rat models with high stiffness background, its clinical...
Metaplasia can result when injury reactivates latent developmental signaling pathways that determine cell phenotype. Barrett's esophagus is a squamous-to-columnar epithelial metaplasia caused by reflux esophagitis. Hedgehog (Hh) active in columnar-lined, embryonic and inactive squamous-lined, adult esophagus. We showed previously Hh reactivated overexpression of Sonic hedgehog (SHH) mouse esophageal squamous epithelium leads to columnar Here, our objective was identify target genes involved...
The mammalian collecting duct comprises principal and intercalated cells, which maintain sodium/water acid/base balance, respectively, but the epigenetic contributors to differentiation of these cell types remain unknown. Here, we investigated whether histone H3 K79 methyltransferase Dot1l, is highly expressed in participates this process. Taking advantage distribution aquaporin 2 (Aqp2), localizes cells duct, developed mice lacking Dot1l Aqp2-expressing (Dot1lAC) found that had...
Abstract Backgrounds Hand grip strength (HGS) is one of diagnose criteria factors sarcopenia and associated with the survival patients cancer. However, few studies have addressed association HGS 1 year mortality cancer cachexia. Methods This cohort study included 8466 malignant solid tumour from 40 clinical centres throughout China. Cachexia was diagnosed using 2011 International cachexia consensus. The hazard ratio (HR) all calculated Cox proportional regression models. Kaplan–Meier curves...
Abstract Background Tactile and mechanical pain are crucial to our interaction with the environment, yet underpinning molecular mechanism is still elusive. Endophilin A2 (EndoA2) an evolutionarily conserved protein that documented in endocytosis pathway. However, role of EndoA2 regulation sensitivity its underlying mechanisms currently unclear. Methods Male female C57BL/6 mice (8–12 weeks) male cynomolgus monkeys (7–10 years old) were used experiments. Nerve injury-, inflammatory-,...
Dot1l encodes histone H3 K79 methyltransferase Dot1a. Mice with deficiency in renal Aqp2-expressing cells (Dot1lAC) develop polyuria by unknown mechanisms. Here, we report that Aqp5 links deletion to through Aqp2. cDNA array analysis revealed and real-time RT-qPCR validated as the most upregulated gene Dot1lAC vs. control mice. protein is barely detectable controls, but robustly expressed kidneys, where it colocalizes The upregulation of coupled reduced association Dot1a dimethyl specific...
In an earlier study wherein we induced acute reflux by interrupting proton pump inhibitor (PPI) therapy in patients with oesophagitis (RO) healed PPIs, refuted the traditional concept that RO develops as acid burn. The present explored our alternative hypothesis results from reflux-stimulated production of pro-inflammatory molecules mediated hypoxia-inducible factors (HIFs).Using oesophageal biopsies taken at baseline and 1 2 weeks off immunostained for HIF-1α, HIF-2α phospho-p65, measured...
Recently, albumin-globulin ratio (AGR), a serological indicator that reflects nutritional status and systemic inflammatory, has been reported to be associated with the prognosis of various cancers. However, there is currently no research report on its relationship cancer cachexia.
Objective Systemic inflammation and malnutrition are correlated with cancer sarcopenia have deleterious effects on oncological outcomes. However, the combined effect of in patients remains unclear. Methods We prospectively collected information 1,204 diagnosed sarcopenia. mean (SD) age was 64.5 (11.4%) years, 705 (58.60%) were male. The categorized into high advanced lung index (ALI) group (≥18.39) low ALI (<18.39) according to optimal survival cut-off curve. selected marker using...
Body water measured by bioelectrical impedance analysis (BIA) predicts the outcomes of many diseases. This study aimed to evaluate relationship between body and prognosis cancer patients with sarcopenia.This employed 287 sarcopenia underwent BIA from a prospective multicenter in China 2013 2020. The primary outcome interest was all-cause mortality presented as longest time follow-up available. Eight indicators [total water, extracellular intracellular free fat mass, active cell...
Abstract Background Changes in body composition and systemic inflammation are important characteristics of cancer cachexia. This multi‐centre retrospective study aimed to explore the prognostic value combination patients with Methods The modified advanced lung index (mALI), which combines inflammation, was defined as appendicular skeletal muscle (ASMI) × serum albumin/neutrophil‐lymphocyte ratio. ASMI estimated according a previously validated anthropometric equation. Restricted cubic...
Membranes allowing the sustained release of drugs that can achieve cell adhesion are very promising for guided bone regeneration. Previous studies have suggested aspirin has potential to promote The purpose this study was prepare a local drug delivery system with aspirin-loaded chitosan nanoparticles (ACS) contained in an asymmetric collagen-chitosan membrane (CCM).In study, ACS were fabricated using different concentrations (5 mg, 25 50 and 75 mg). behavior studied. Transmission electron...
Serum albumin can indicate the onset of cancer cachexia, provide information about a patient's nutritional status, and serve as biomarker for prognosis patients with cachexia. However, relationship between serum levels mortality in cachexia remains unclear. We aimed to examine association total protein 1-year cachexia.We conducted nested case-control study using data from multicenter clinical survey 2013 2018. In total, 266 who survived <1 year ≥1 were included this study. The participants...
Background: Malnutrition is common in patients with cancer and associated adverse outcomes, but few data exist elderly patients. The aim of this study was to report the prevalence malnutrition using three different scoring systems examine possible clinical relationship prognostic consequence cancer. Methods: Nutritional status assessed by controlling nutritional (CONUT), index (PNI), risk (NRI). Quality-of-life (Qol) during admission European Organization for Research Treatment Cancer...