A5077163190- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- MicroRNA in disease regulation
- Thermoregulation and physiological responses
- Intensive Care Unit Cognitive Disorders
- Cancer, Hypoxia, and Metabolism
- Ultrasound in Clinical Applications
- Thermal Regulation in Medicine
- Heme Oxygenase-1 and Carbon Monoxide
- Traumatic Brain Injury and Neurovascular Disturbances
- Hemodynamic Monitoring and Therapy
- Effects of Radiation Exposure
- S100 Proteins and Annexins
- Health disparities and outcomes
- Ion Channels and Receptors
- Amyotrophic Lateral Sclerosis Research
- RNA modifications and cancer
- Peroxisome Proliferator-Activated Receptors
- Sirtuins and Resveratrol in Medicine
- Burn Injury Management and Outcomes
- Health, psychology, and well-being
- Spinal Cord Injury Research
- Cardiac Arrest and Resuscitation
- Hydrogen's biological and therapeutic effects
- RNA Interference and Gene Delivery
General Hospital of Shenyang Military Region
2015-2025
Command Hospital
2022
To explore the effect of microRNA-132 heart failure and provide theoretical guidance for clinical treatment (HF).Peripheral blood was collected from HF patients. RT-qPCR used to determine expression. Mouse models were established. Color Doppler ultrasound utilized measure changes cardiac function. HE Masson staining applied observe pathological myocardium. After H9C2 cells transfected with microRNA-132, MTT assay employed detect stability cells. ELISA levels oxidative stress factors. Western...
Objective To investigate the protective effect of chitosan oligosaccharide (COS) on acute lung injury (ALI) caused by blast injury, and explore possible molecular mechanisms. Methods A mouse model injury-induced ALI was established using a self-made explosive device. Thirty mice were randomly assigned to control, + COS groups. An eight-channel physiological monitor used determine index. Enzyme linked immunosorbent assay measure serum inflammatory factors. Hematoxylin-eosin staining, terminal...
Background Self-efficacy, perceived social support, and resilience in caregivers of first-stroke patients are closely related, while the interaction mechanism remains unclear. This research explores mediation effect self-efficacy relationship between support China.
Although CD28 is associated with the expression of inflammatory mediators, apoptosis-related protein, immunosuppression, and tumorigenesis, effects deficiency on blast exposure-induced lung injury have not been investigated. In this study, we explored studied its potential molecular mechanisms. A mouse model acute was established. Sixty C57BL/6 wild-type (WT) knockout (CD28-/-) mice were randomly divided into control or groups. Lung tissue samples collected 24 h 48 after injury....
Abstract Cold injury refers to local or systemic caused by a rapid, massive loss of body heat in cold environment. The incidence is high. However, the current situation regarding diagnosis and treatment our country not ideal. To standardize improve level clinical China, it necessary make consensus that practical adapted conditions China. We used latest population-level epidemiological research data, combined with relevant literature from China foreign countries. was developed joint committee...
Summary Acute lung injury ( ALI ) is one of the most serious complications in traumatic patients and an important part multiple organ dysfunction syndrome MODS ). Recombinant human brain natriuretic peptide (rh BNP a with wide range biological activity. In this study, we investigated local changes oxidative stress NF ‐κB‐dependent matrix metalloproteinase‐9 MMP ‐9) pathway rats trauma/haemorrhagic shock TH /S)‐induced evaluated effects pretreatment rh . Forty‐eight were randomly divided into...
Explosion-induced injury is the most commonly encountered wound in modern warfare and incidents. The vascular inflammatory response subsequent oxidative stress are considered key causes of morbidity mortality among those blast lung injury. It has been reported dimethylarginine dimethylaminohydrolase 1 (DDAH1) plays important roles regulating endothelial repair angiogenesis, but its role explosion-induced remains to be explained. To explore mechanism lung, 40 C57BL/6 wild type mice DDAH1...
Blast exposure is a worldwide public health concern, but most related research has been focused on direct injury. Thoracic blast exposure-induced neurotrauma type of indirect injuries where lacking. As CD28 stimulates T cell activation and survival contributes to inflammation initiation, it may play role in thoracic neurotrauma. However, not investigated. To explore the effects brain injury its potential molecular mechanisms, mouse model was established. Fifty C57BL/6 wild-type (WT) fifty...
Sepsis is a common life-threatening pathological process. However, the transformation efficiency of studies on treatment sepsis relatively low. Therefore, hotspot and trend development study was attempted area in accordance with literature. We selected 2511 most related to within past 5 years as research samples. Text co-word matrix were established by analyzing selecting high-frequency words using BICOMB software. Classifications areas obtained through biclustering visual analysis Ggluto...
This study aims to investigate the effect of adipose-derived stem cells (ADSCs) transplantation on progranulin (PGRN) expression and functional recovery in rats with spinal cord injury (SCI). ADSCs were isolated from inguinal adipose tissue rats. A SCI model was created, injected into injured area. Various techniques used assess effects transplantation, including hematoxylin-eosin staining, Masson immunofluorescence electron microscopy, MRI, motor function assessment. The potential...
Patients with sepsis are often comorbid acute respiratory distress syndrome (ARDS), and the phenotypic characteristics of pulmonary non-pulmonary infections leading to ARDS still unclear. This study aimed compare resulting from other non-site provide better guidance for clinical treatment.
Objective To observe the protective effects of peroxisome proliferation activated receptorβ (PPAR-b) on acute lung injury in wake hemorrhagic shock rats order to illuminate mechanism.Methods After ALI model rat was established following shock,96 SD were divided randomly (random number) into 4 groups:group A (sham operation group),group B (ALI C (GSK0660,an antagonist PPAR-b given prior exsanguinations for pretreatment) and group D (GW0742,an agonist before pretreatment).Each further 1 h,2...
Background: Cold exposure can induce inflammation-related injury in lung tissue, but the exact mechanism is still unclear. Objective: The study aimed to clarify proteomic characteristics of tissue under cold exposure. Methods: Forty mice were randomly equally divided into a control group and model group. was exposed - 20°C for two weeks (4 hours per day), while maintained at 22 ± 2°C. H&E staining ELISA used verify tissue. Furthermore, quantitative analysis overall proteome stress...