A5101930949- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Mesenchymal stem cell research
- Hematopoietic Stem Cell Transplantation
- Liver Disease and Transplantation
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Virus-based gene therapy research
- Metabolomics and Mass Spectrometry Studies
- T-cell and B-cell Immunology
- Bipolar Disorder and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Organ Transplantation Techniques and Outcomes
- Obstructive Sleep Apnea Research
- Schizophrenia research and treatment
- Reproductive System and Pregnancy
- Galectins and Cancer Biology
- Monoclonal and Polyclonal Antibodies Research
- Xenotransplantation and immune response
- Cardiovascular and Diving-Related Complications
- Corneal Surgery and Treatments
- Viral gastroenteritis research and epidemiology
- Renal and related cancers
- Reconstructive Surgery and Microvascular Techniques
Capital Medical University
2020-2025
Fudan University
2025
Pudong Medical Center
2025
General Hospital of Shenyang Military Region
2012-2025
Nanjing Drum Tower Hospital
2024
Beijing YouAn Hospital
2024
Sichuan University
2023
Shenzhen University
2023
Zhengzhou University
2023
Eastern Hepatobiliary Surgery Hospital
2022
Metabolic profiles of biofluids obtained by atmospheric pressure ionization mass spectrometry-based technologies contain hundreds to thousands features, most them remaining unknown or at least not characterized in analytical systems. We report here on the annotation human adult urinary metabolome and metabolite identification from electrospray spectrometry (ESI-MS)-based metabolomics data sets. Features biological interest were first all annotated using ESI-MS database laboratory. They also...
OBJECTIVE: This study assessed treatment rates and expenditures for behavioral health care by employers patients in a large national database of employer-sponsored insurance claims. METHOD: Insurance claims from 1996 approximately 1.66 million individuals were examined. Average annual charges per person payments calculated along with patient out-of-pocket expenses inpatient hospital admission rates. Behavioral bipolar disorder compared to other diagnoses these same plans. RESULTS: A total...
Glioma is the most common primary intracranial malignant tumor. Despite advances in surgical techniques and adjuvant radio- chemotherapies, prognosis for patients with glioma remains poor. We have explored effects of using genetically modified mesenchymal stem cells (MSCs) to treat rats. Mesenchymal isolated from Sprague-Dawley rats can directly suppress growth C6 vitro. MSCs transplanted intratumorally also significantly inhibit prolong survival glioma-bearing models. producing...
BackgroundLimited studies have been done on chronic hepatitis B (CHB) patients defined according to the latest Asian-Pacific Association for Study of Liver guideline with liver histology by a large sample size. MethodsWe retrospectively evaluated histological characteristics cohort consecutive treatment-naive CHB persistent normal alanine aminotransferase (PNALT) or elevated ALT from May 2005 October 2011. Histological assessment was based Metavir scoring system, significant abnormality as...
T lymphocytes, which recognize antigen peptides through specific cell receptors (TCRs), play an important role in the human adaptive immune response. TCR diversity is closely associated with host response and cancer prognosis. Although tumor-infiltrating lymphocytes have implications for tumor prognosis, few studies performed a detailed characterization of both non-tumor tissues hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC). Here, we high-throughput sequencing TCRβ chain...
We propose a Corrected Goodness-of-Fit Index (CGFI) for model evaluation in Structural Equation Modeling (SEM). The CGFI is essentially corrected index that takes into account complexity and downward bias caused by small sample size. Using simulations based on pre-set SEM models, we compared the properties of CGFI, (GFI), Adjusted (AGFI) under different settings size, estimation method, magnitude factor loadings, complexity, types degrees misspecification. find more stable across sizes much...
Female fertility decline is an accumulative consequence caused by complex factors, among them, the disruption of immune profile in female reproduction stands out as a crucial contributor. Presently, effects microenvironment (IME) on reproductive process have attracted increasing attentions for their dynamic but precisive roles. Immunocytes including macrophages, dendritic cells, T B cells and neutrophils, with diverse subpopulations well high plasticity functioned dynamically through...
Background The epidemiology of hepatitis D virus (HDV) in China is fairly unknown. mechanisms whereby HDV leads to accelerated liver disease B (HBV)/HDV co-infected patients and the histological characteristics chronic (CHD) need further investigation. Methods prevalence was retrospectively evaluated all consecutive hospitalized with HBV infection from May 2005 October 2011. HBV/HDV mono-infected were compared clinically histologically. Significant abnormality defined as significant...
In order to provide non-invasive, reliable and sensitive laboratory parameters for the diagnosis of primary biliary cirrhosis (PBC), metabolic technology ultraperformance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UPLC/Q-TOF MS) was used compare small molecule metabolites in blood urine from patients PBC healthy controls. We then screened bio-markers PBC. Data were processed by Bruker ProfileAnalysis metabonomic software imported SIMCA-P software, which...
Immunosuppressive therapy with antithymocyte immunoglobulin (ATG) and cyclosporine A is the first treatment option for severe aplastic anemia (SAA) patients without transplantation. Horse ATG not marketed in China. Because price of porcine (pATG) only about one-third rabbit (rATG), long-term follow-up studies pATG's efficacy will help provide valuable insights into SAA. Retrospective were performed to analyze clinical information 102 SAA treated pATG from 1999 2014 Peking Union Medical...
Although CD28 is associated with the expression of inflammatory mediators, apoptosis-related protein, immunosuppression, and tumorigenesis, effects deficiency on blast exposure-induced lung injury have not been investigated. In this study, we explored studied its potential molecular mechanisms. A mouse model acute was established. Sixty C57BL/6 wild-type (WT) knockout (CD28-/-) mice were randomly divided into control or groups. Lung tissue samples collected 24 h 48 after injury....
Transplant centers are increasingly using livers from donors aged >60 years, but long-term outcomes remain unclear. We collected data 957 adult deceased donor liver transplant recipients (conducted at our center January 2015 through October 2023). The cohort was divided into early, middle, and late era groups, each covering a 3-year interval based on date. compared 183 ≥60 years (older group [average age 64.9 ± 3.4 y]) versus 774 18 to 59 (young group), which we also after propensity score...
Intraoperative radiotherapy (IORT) is an emerging local therapy in the surgery of intra-axial brain tumors to improve clinical outcomes and accelerate adjuvant oncologic therapy. Despite its use neuro-oncology, data regarding role IORT treatment high-grade gliomas (HGGs) sparse. Here we reported our single-institutional evidence concerning efficacy safety management HGGs. A total thirty patients diagnosed with HGGs who underwent surgical at center between October 2021 2023 were included....
Abstract Background Mesenchymal stem cells (MSCs) are a population of pluripotent that might be used for treatment liver disease. However, the efficacy MSCs mice with alcoholic hepatitis (AH) and its underlying mechanism remains unclear. Methods were isolated from bone marrow (BM) 4–6-week-old male C57BL/6 N mice. AH was induced in female by chronic-binge ethanol feeding 10 days. The given intraperitoneal injections or without transfection AG490, recombinant mouse tumor necrosis factor...
To evaluate the treatment efficacy and tolerance of anti-human T lymphocyte porcine immunoglobulin (p-ALG) plus cyclosporine A (CsA) in acquired severe aplastic anemia (SAA).Forty-eight SAA patients [31 males 17 females; with very (VSAA)] were treated p-ALG CsA analyzed retrospectively according to early mortality, response rate quality, survival rate, toxicity, complications. They stratified further by gender, age, disease severity, interval from diagnosis treatment, preexisting...
Abstract Profiling immune repertoires by high throughput sequencing enhances our understanding of system complexity and immune-related diseases in humans. Previously, cloning Sanger identified limited numbers T cell receptor (TCR) nucleotide sequences rhesus monkeys, thus their full repertoire is unknown. We applied multiplex PCR Illumina to study the TCRβ monkeys. 1.26 million corresponding 643,570 unique 270,557 complementarity-determining region 3 (CDR3) gene sequences. Precise...