A5101504008- Ferroptosis and cancer prognosis
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Cancer, Lipids, and Metabolism
- Immunotherapy and Immune Responses
- Circular RNAs in diseases
- RNA modifications and cancer
- Acute Myocardial Infarction Research
- Immunodeficiency and Autoimmune Disorders
- Cancer-related molecular mechanisms research
- Cytomegalovirus and herpesvirus research
- Cardiac Imaging and Diagnostics
- Liver physiology and pathology
- Coronary Interventions and Diagnostics
- Liver Diseases and Immunity
- Biomarkers in Disease Mechanisms
- Cancer Immunotherapy and Biomarkers
- Mycobacterium research and diagnosis
- Phagocytosis and Immune Regulation
Jiaxing University
2021-2023
Qingdao University
2023
Affiliated Hospital of Qingdao University
2023
First Hospital of Jiaxing
2017-2021
Southern Medical University
2014-2016
Nanfang Hospital
2016
T lymphocytes, which recognize antigen peptides through specific cell receptors (TCRs), play an important role in the human adaptive immune response. TCR diversity is closely associated with host response and cancer prognosis. Although tumor-infiltrating lymphocytes have implications for tumor prognosis, few studies performed a detailed characterization of both non-tumor tissues hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC). Here, we high-throughput sequencing TCRβ chain...
Background The epidemiology of hepatitis D virus (HDV) in China is fairly unknown. mechanisms whereby HDV leads to accelerated liver disease B (HBV)/HDV co-infected patients and the histological characteristics chronic (CHD) need further investigation. Methods prevalence was retrospectively evaluated all consecutive hospitalized with HBV infection from May 2005 October 2011. HBV/HDV mono-infected were compared clinically histologically. Significant abnormality defined as significant...
In clinical practice, the clinicopathological profiles and outcomes of patients infected with hepatitis B virus (HBV) are different between genotypes C. However, little is known about potential mechanism differences in specific biological pathways associated genotype. This study aimed to compare serum protein profile HBV genotype those C.A total 54 samples from chronic infection C infection, healthy controls were used for proteomic analysis (n = 18 per group). Serum analyzed using...
Long-term treatment with nucleos(t)ide analogues (NUCs) can improve the antiviral T cell response in chronic hepatitis B (CHB) patients. Whether and to what extent is improved by NUCs early stage leading e antigen (HBeAg) seroconversion remain be clarified. A total of 22 CHB patients undergoing 2-year telbivudine-based therapy were enrolled, including 10 exhibiting a complete (CR) 12 non-complete (NCR) according HBeAg at week 52. Peripheral CD4+ CD8+ cells sorted baseline, weeks 24. The...
Background: Hepatic stellate cells (HSCs) are liver-specific pericytes that transform into myofibroblasts, which involved in pathological vascularization liver fibrosis. We previously suggested A20 overexpression suppresses lipopolysaccharide (LPS)-induced inflammation HSC. aimed to determine the mechanisms of anti-inflammatory role LX-2 cells. Methods: were transfected with A20-siRNA or control-siRNA and control adenovirus A20-carrying adenovirus. Quantitative reverse transcription PCR...