A5101450135- Functional Brain Connectivity Studies
- Blood Pressure and Hypertension Studies
- Helicobacter pylori-related gastroenterology studies
- Hormonal Regulation and Hypertension
- Diabetes Treatment and Management
- Gastroesophageal reflux and treatments
- Dementia and Cognitive Impairment Research
- Sodium Intake and Health
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Receptor Mechanisms and Signaling
- Mental Health Research Topics
- Drug Transport and Resistance Mechanisms
- Liver Disease Diagnosis and Treatment
- Sleep and related disorders
- Sleep and Wakefulness Research
- Cardiac electrophysiology and arrhythmias
- Pharmaceutical studies and practices
- Biochemical and Molecular Research
- PARP inhibition in cancer therapy
- HIV Research and Treatment
- Cancer-related Molecular Pathways
- Antiplatelet Therapy and Cardiovascular Diseases
- Advanced MRI Techniques and Applications
- Cancer Immunotherapy and Biomarkers
Second Affiliated Hospital of Xi'an Jiaotong University
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Northwest A&F University
2024
Takeda (United States)
2008-2023
Victor Chang Cardiac Research Institute
2023
Nanchang University
2022
Hunan Normal University
2019-2021
Central South University
2020-2021
Takeda (Japan)
2020
Weatherford College
2020
Narcolepsy type 1 is caused by severe loss or lack of brain orexin neuropeptides.We conducted a phase 2, randomized, placebo-controlled trial TAK-994, an oral receptor 2-selective agonist, in patients with narcolepsy 1. Patients confirmed according to clinical criteria were randomly assigned receive twice-daily TAK-994 (30 mg, 90 180 mg) placebo. The primary end point was the mean change from baseline week 8 average sleep latency (the time it takes fall asleep) on Maintenance Wakefulness...
TAK‐875 is a selective G‐protein‐coupled receptor 40 agonist in development for the treatment of type 2 diabetes mellitus. This randomized, double‐blind, placebo‐controlled study evaluated safety, tolerability, pharmacokinetics, and pharmacodynamics following administration single oral dose (25–800 mg) 60 healthy volunteers. was eliminated slowly with mean terminal elimination t 1/2 approximately 28.1 to 36.6 hours. Systemic exposure did not exhibit dose‐proportional increases across range...
Dural arteriovenous fistulas (DAVFs) pose a significant health threat owing to their high misdiagnosis rate. Case reports suggest that DAVFs or related acute events may follow medication use; however, drug-related risk factors remain unclear. In clinical practice, the concomitant use of multiple drugs for therapy is known as "polypharmacy situations," further increasing drug-induced DAVF. Real-world studies linking medications and DAVF can alert clinicians possibilities contribute...
Normal aging is associated with cognitive decline. Evidence indicates that large-scale brain networks are affected by aging; however, it has not been established whether equivalent effects on specific networks. In the present study, 40 healthy subjects including 22 older (aged 60–80 years) and 18 younger 22–33 adults underwent resting-state functional MRI scanning. Four canonical networks, default mode network (DMN), executive control (ECN), dorsal attention (DAN) salience network, were...
Poly (ADP-ribose) polymerase inhibitors (PARPi) have showed clinical benefit as maintenance therapy in advanced ovarian cancer by impairing the homologous recombination (HR) pathway. Pyruvate kinase M2 (PKM2), significant metabolic biomarker, integrates with DNA damage to directly promote HR. We aimed investigate role and molecular mechanism of PKM2 downregulation on sensitization cells PARPi. Inhibitory effects vitro were assessed cell viability, clone formation, transwell assay, flow...
Background: The musculoskeletal toxicity of immune checkpoint inhibitors (ICIs) is receiving increasing attention with clinical experience. Nevertheless, the absence a systematic investigation into profile ICIs currently results in under-recognition associated adverse events. Further and more comprehensive investigations are warranted to delineate characterize these Material methods: present study employed FDA Adverse Event Reporting System database collect events between January 2010 March...
Dexlansoprazole MR is a proton pump inhibitor with Dual Delayed Release (DDR) formulation designed to prolong the dexlansoprazole plasma concentration-time profile. The presence of food or time dosing relative may affect absorption.To evaluate effect on pharmacokinetics (PK) and pharmacodynamics (PD) following oral administration MR.In this open-label, single-dose, randomized, 4-way crossover study, 48 healthy subjects received placebo (day 1) 90 mg 3) after fasting, 5 30 min before high-fat...
Tandutinib is a tyrosine kinase inhibitor under investigation for the treatment of solid and hematological tumors. We evaluated efflux transporter substrate specificity tandutinib in Caco-2 cells, role transporters disposition rats knock-out mice. These studies demonstrated that P-glycoprotein (P-gp) breast cancer resistance protein (BCRP) cells. In rats, administration GF120918, before with orally resulted approximately seven-fold increase mean plasma area concentration-versus-time curve...
A novel analytical method has been developed for direct quantification of intracellular nucleoside triphosphates (NTPs). Lysates human peripheral blood mononuclear cells (PBMCs) were extracted by protein precipitation, and the filtered extracts analyzed weak anion exchange liquid chromatography (WAX-LC) coupled to detection mass spectrometry (MS). Compared with ion pairing (IP)-LC/MS/MS, only MS-compatible NTPs currently available, new completely avoids usage ion-pairing reagents a shorter...
Abstract Vitamin A (VA) is one of the most widely used food supplements, but its molecular mechanisms largely remain elusive. Previously, we have demonstrated that VA inhibits action lipopolysaccharide (LPS) on intestinal epithelial barrier function and tight junction proteins using IPEC‐J2 cells, representative cell lines as a cellular model. These exciting findings stimulated us continue to determine effects LPS‐induced damage integrity in mice. Our results LPS treatment caused reductions...
Dexlansoprazole MR 30 mg once daily (QD) is approved in adults for the treatment of symptomatic nonerosive gastroesophageal reflux disease (GERD) and maintenance healed erosive esophagitis (EE); 60 healing EE. The present study assesses pharmacokinetic (PK) profile safety dexlansoprazole adolescent patients.Phase 1, open-label, parallel-group, multicenter male female adolescents (12-17 years) with GERD. Patients were randomized to receive (30 or mg, QD) 7 days. Blood samples determine plasma...
Abstract The use of positron emission tomography (PET) in early-phase development novel drugs targeting the central nervous system, is well established for evaluation brain penetration and target engagement. However, when targets are involved a suitable PET ligand not always available. We demonstrate an alternative approach that evaluates attenuation amphetamine-induced synaptic dopamine release by agonist orphan G-protein-coupled receptor GPR139 (TAK-041). agonism candidate mechanism...
A single injection of 20 IU PMS on Day 30 and 1.2 HCG intravenously 32 caused superovulation in the rats and, if mated evening 32, an average 22.8 implantation sites Days 10 to 13 pregnancy. Thirteen 26 blastocysts were recovered from uteri ovariectomized 3 pregnancy given 2 mg progesterone daily starting 3. Implantation these was induced by a 1 μg estrone. An 17.3 obtained when plus used, 7.7 given. The method for inducing provides means obtaining large numbers 4 or 5 post-insemination,...
Mitochondrial dysfunction is implicated in the pathophysiology of Alzheimer's disease (AD). Accordingly, drugs that positively influence mitochondrial function are being evaluated delay-of-onset clinical trials with at-risk individuals. Such ongoing research can be advanced by developing a better understanding how these affect intermediate brain phenotypes associated both AD risk and pathophysiology.Using randomized, parallel-group, placebo-controlled design 55 healthy elderly volunteers, we...