A5065302167- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Transcranial Magnetic Stimulation Studies
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Electromagnetic Fields and Biological Effects
- Physiological and biochemical adaptations
- Neurological disorders and treatments
- Fish biology, ecology, and behavior
- Cephalopods and Marine Biology
- Traumatic Brain Injury Research
- Marine animal studies overview
- Advanced Neuroimaging Techniques and Applications
- Neonatal and fetal brain pathology
- Muscle activation and electromyography studies
- EEG and Brain-Computer Interfaces
- Parkinson's Disease Mechanisms and Treatments
- Magnetic and Electromagnetic Effects
- Nerve injury and regeneration
- Cardiac Arrest and Resuscitation
- Spinal Cord Injury Research
- Molecular Communication and Nanonetworks
- Veterinary Pharmacology and Anesthesia
Michigan State University
2018-2025
Michigan United
2021
Johns Hopkins University
2010-2020
Johns Hopkins Medicine
2011-2020
Kennedy Krieger Institute
2010-2019
Institute of Molecular Functional Materials
2009
National Institutes of Health
2005-2008
National Institute of Neurological Disorders and Stroke
2007-2008
Hadassah Medical Center
2007
Hebrew University of Jerusalem
2004-2005
Repetitive Transcranial Magnetic Stimulation (rTMS) has been successfully used as a non-invasive therapeutic intervention for several neurological disorders in the clinic well an investigative tool basic neuroscience. rTMS shown to induce long-term changes neuronal circuits vivo. Such effects of have investigated using behavioral, imaging, electrophysiological, and molecular approaches, but there is limited understanding immediate TMS on neurons. We high frequency (20 Hz) activity cortical...
The ability to manipulate cellular function using an external stimulus is a powerful strategy for studying complex biological phenomena. One approach modulate the of environment split proteins. In this method, biologically active protein or enzyme fragmented so that it reassembles only upon specific stimulus. Although many tools are available induce these systems, nature has provided other mechanisms expand toolbox. Here, we show novel method reconstituting proteins magnetic stimulation. We...
Multielectrode arrays for interfacing with neurons are of great interest a wide range medical applications. However, current electrodes cause damage over time. Ultra small carbon fibers help to address issues but controlling the electrode site geometry is difficult. Here we propose methodology create small, pointed fiber (SPFe). We compare SPFe previously made blowtorched in characterization. The result sizes (105.4 ± 20.8 μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...
In the weeks following unilateral peripheral nerve injury, deprived primary somatosensory cortex (SI) responds to stimulation of ipsilateral intact limb as demonstrated by functional magnetic resonance imaging (fMRI) responses. The neuronal basis these responses was studied using high-resolution fMRI, in vivo electrophysiological recordings, and juxtacellular labeling rats that underwent an excision forepaw radial, median, ulnar nerves. These nerves were exposed but not severed control rats....
Peripheral nerve injury causes sensory dysfunctions that are thought to be attributable changes in neuronal activity occurring somatosensory cortices both contralateral and ipsilateral the injury. Recent studies suggest distorted functional response observed deprived primary cortex (S1) may result of an increase inhibitory interneuron is mediated by transcallosal pathway. The goal this study was develop a strategy manipulate control facilitate appropriate plasticity guiding cortical...
Abstract Traumatic brain injury (TBI) is the leading cause of death and disability among children in United States. Affected will often suffer from emotional, cognitive neurological impairments throughout life. In controlled cortical impact (CCI) animal model pediatric TBI (postnatal day 16–17) it was demonstrated that results abnormal neuronal hypoactivity non-injured primary somatosensory cortex (S1). It materializes reshaping post-injury activity may provide a suitable strategy to augment...
Abstract Purpose: Protein kinases including protein kinase A (PKA) underlie myriad important signaling pathways. The ability to monitor activity in vivo and real‐time with high spatial resolution genetically specified cellular populations is a yet unmet need, crucial for understanding complex biological systems as well preclinical development screening of novel therapeutics. Methods: Using the hypothesis that natural recognition sequences may be detected using chemical exchange saturation...
The Kryptopterus bicirrhis (glass catfish) is known to respond electromagnetic fields (EMF). Here we tested its avoidance behavior in response static and alternating magnetic stimulation. Using expression cloning identified an perceptive gene (EPG) from the K. encoding a protein that responds EMF. This EPG was cloned expressed mammalian cells, neuronal cultures rat's brain. Immunohistochemistry showed of confined cell membrane. Calcium imaging cells cultured neurons expressing demonstrated...
Beta-endorphin is an endogenous opioid peptide that has been hypothesized to be involved in the behavioral effects of drugs abuse including psychostimulants. Using microdialysis, we studied effect cocaine on extracellular levels beta-endorphin nucleus accumbens, a brain region reinforcing psychostimulant drugs. Experimenter-delivered (2 mg/kg, i.v.) increased immunoreactive attenuated by 6-hydroxy-dopamine lesions or systemic administration D1-like receptor antagonist, SCH-23390 (0.25 i.p.)....
The robustness of plasticity mechanisms during brain development is essential for synaptic formation and has a beneficial outcome after sensory deprivation. However, the role in recovery acute injury children not been well defined. Traumatic (TBI) leading cause death disability among children, long-term from pediatric TBI can be particularly devastating. We investigated altered cortical 2-3 weeks rat model TBI. Significant decreases neurophysiological responses across depth noninjured,...
BackgroundTwenty million Americans suffer from peripheral nerve injury. These patients often develop chronic pain and sensory dysfunctions. In the past decade, neuroimaging studies showed that these changes are associated with altered cortical excitation-inhibition balance maladaptive plasticity. We tested if neuromodulation of deprived cortex could restore balance, whether it would be effective in alleviating complications.ObjectiveWe non-invasive repetitive transcranial magnetic...
Introduction: Spinal cord injury (SCI) causes partial or complete damage to sensory and motor pathways induces immediate changes in cortical function. Current rehabilitative strategies do not address this early alteration, therefore impacting the degree of neuroplasticity subsequent recovery. The following study aims test if a non-invasive brain stimulation technique such as repetitive transcranial magnetic (rTMS) is effective promoting plasticity rehabilitation, can be used an intervention...
Studies at the cellular and molecular level of magnetoreception-sensing responding to magnetic fields-are a relatively new research area. It appears that different mechanisms magnetoreception in animals evolved from origins, and, therefore, many questions about its remain left open. Here we present information regarding Electromagnetic Perceptive Gene (EPG)
Abstract Functional magnetic resonance imaging (fMRI) is used to investigate the basal ganglia (BG)–cortex circuit using a rat model of Parkinson's disease (PD). The involves unilateral destruction right substantia nigra by intranigral injection dopaminergic neurotoxin 6‐hydroxydopamine. Volume cortical activity was measured blood oxygenation level‐dependent contrast method while applying electrical forepaw stimulation. main findings are following. (i) Contrary predictions classic but in...
Abstract Purpose To measure intra‐ and inter‐hemispheric connectivity within the basal ganglia (BG) nuclei in healthy unilateral 6‐hydroxydopamine (6‐OHDA) Parkinson disease rat model order to test BG interhemispheric hypothesis. Material Methods The manganese‐enhanced MRI (MEMRI) method with direct injection of manganese chloride into entopeduncular (EP), substantia nigra (SN), Habenula 6‐OHDA ( N = 22) sham‐operated 16) groups was used. MEMRI measurements were applied before, 3, 24, 48...
Developing synthetic biological devices to allow the noninvasive control of cell fate and function, in vivo can potentially revolutionize field regenerative medicine. To address this unmet need, we designed an artificial “switch” that consists two parts: (1) electromagnetic perceptive gene (EPG) (2) magnetic particles. Our group has recently cloned EPG from Kryptopterus bicirrhis (glass catfish). The encodes a putative membrane-associated protein responds fields (EMFs). This gene’s primary...
Abstract The octopus has many features that make it advantageous for revealing principles of motor circuits and control predicting behavior. Here, an array carbon electrodes providing single-unit electrophysiology recordings were implanted into the anterior nerve cord. number spikes arm movements in response to stimulation at different locations along recorded. We observed occurring within first 100 ms after predictive resultant movement response. Machine learning models showed temporal...
This study investigates the effects of mild traumatic brain injury (mTBI) on gait in Yucatan minipigs, a relevant animal model for assessing balance impairments after TBI. Retro-reflective markers were placed different anatomical locations pig, and eight motion capture cameras set up along sides pig walking path to natural data. Pigs tested both before induced head injury, allowing direct comparison alterations. Our findings reveal significant impairments, including reduced shoulder...