A5090414812- Advanced MRI Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Seismic Imaging and Inversion Techniques
- MRI in cancer diagnosis
- Photoacoustic and Ultrasonic Imaging
- Optical Imaging and Spectroscopy Techniques
- Seismic Waves and Analysis
- Electron Spin Resonance Studies
- Medical Imaging Techniques and Applications
- Hydraulic Fracturing and Reservoir Analysis
- Geophysical Methods and Applications
- Magnetism in coordination complexes
- Acupuncture Treatment Research Studies
- Advanced Image Processing Techniques
- Biosensors and Analytical Detection
- Advanced biosensing and bioanalysis techniques
- Spectroscopy Techniques in Biomedical and Chemical Research
- Medical Image Segmentation Techniques
- Healthcare and Venom Research
- Drilling and Well Engineering
- Action Observation and Synchronization
- Hydrocarbon exploration and reservoir analysis
- Neurogenesis and neuroplasticity mechanisms
- Radioactive element chemistry and processing
- Cardiac tumors and thrombi
Tsinghua University
2005-2025
Southeast University
2021-2024
Nanjing University of Information Science and Technology
2023-2024
First Affiliated Hospital of Henan University
2022-2024
The First Hospital of Kunming
2024
Binzhou University
2024
Binzhou Medical University
2024
Minjiang University
2020-2023
Guangzhou University of Chinese Medicine
2022
Changchun University of Technology
2022
Reports on bacteria detected in maternal fluids during pregnancy are typically associated with adverse consequences, and whether the female reproductive tract harbours distinct microbial communities beyond vagina has been a matter of debate. Here we systematically sample microbiota within 110 women age, examine nature colonisation by 16S rRNA gene amplicon sequencing cultivation. We find cervical canal, uterus, fallopian tubes peritoneal fluid, differing from that vagina. The results reflect...
ABSTRACT We consider the problem of constructing a wave extrapolation operator in variable and possibly anisotropic medium. Our construction involves Fourier transforms space combined with help lowrank approximation space‐wavenumber wave‐propagator matrix. A implies selecting small set representative spatial locations wavenumbers. present mathematical derivation this method, description algorithm numerical examples that confirm validity proposed approach. Wave using can be applied to seismic...
Multiplexed detection of Alzheimer's disease (AD) core biomarkers is great significance to early diagnosis and personalized treatment AD patients. Herein, we construct a robust convenient surface-enhanced Raman scattering (SERS) biosensing platform for simultaneous Aβ(1–42) oligomers Tau protein using different dye-coded polyA aptamer-AuNPs (PAapt-AuNPs) conjugates. This strategy relies on the specific protein–aptamer binding-mediated aggregation AuNPs concomitant plasmonic coupling effect...
We introduce a novel finite-difference (FD) approach for seismic wave extrapolation in time. derive the coefficients of operator from lowrank approximation space-wavenumber, wave-propagator matrix. Applying technique finite-differences, we also improve finite difference scheme two-way Fourier differences (FFD). call new (LFFD). Both FD and FFD methods can be applied to enhance accuracy imaging by reverse-time migration. Numerical examples confirm validity proposed technique.
Excessive accumulations of reactive oxygen species (ROS) and amyloid-β (Aβ) protein are closely associated with the complex pathogenesis Alzheimer's disease (AD). Therefore, approaches that synergistically exert elimination ROS dissociation Aβ fibrils effective therapeutic strategies for correcting AD microenvironment. Herein, a novel near infrared (NIR) responsive Prussian blue-based nanomaterial (PBK NPs) is established excellent antioxidant activity photothermal effect. PBK NPs possess...
The excessive depositions of β-amyloid (Aβ) and abnormal level reactive oxygen species (ROS) are considered as the important pathogenic factors Alzheimer's disease (AD). Strategies targeting only one them have no obvious effects in clinic. In this study, a multifunctional nanocarrier CICe@M-K that crosses blood–brain barrier (BBB) efficiently was developed for inhibiting Aβ aggregation scavenging ROS synchronously. Antioxidant curcumin (Cur) photosensitizer IR780 were loaded mesoporous...
With the development of in-vivo free-space fluorescence molecular imaging and multi-modality for small animals, there is a need new reconstruction methods real animal-shape models with large dataset. In this paper we are reporting novel hybrid adaptive finite element algorithm tomography reconstruction, based on linear scheme. Two different inversion strategies (Conjugate Gradient Landweber iterations) separately applied to first mesh level succeeding levels. The was validated by numerical...
More than water: Chemical exchange saturation transfer (CEST) contrast agents have used water bound to lanthanides as a source of highly shifted exchangeable proton frequencies. Compounds with the 2-hydroxybenzoic acid scaffold were investigated protons for CEST MRI contrasting. As service our authors and readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed may be re-organized online delivery, but not copy-edited or typeset. Technical...
Genetically engineered reporters have revolutionized the understanding of many biological processes. MRI-based reporter genes can dramatically improve our ability to monitor dynamic gene expression and allow coregistration subcellular genetic information with high-resolution anatomical images. We developed a biocompatible MRI based on human gene, protamine-1 (hPRM1). The arginine-rich hPRM1 (47% arginine residues) generates high contrast chemical exchange saturation transfer (CEST)...
Alterations in mucin expression and glycosylation are associated with cancer development. Underglycosylated mucin-1 (uMUC1) is overexpressed most malignant adenocarcinomas of epithelial origin (for example, colon, breast ovarian cancer). Its counterpart MUC1 a large polymer rich glycans containing multiple exchangeable OH protons, which readily detectable by chemical exchange saturation transfer (CEST) MRI. We show here that deglycosylation results >75% reduction CEST signal. Three uMUC1(+)...
ABSTRACT Dopamine receptor DRD1-expressing medium spiny neurons (D1 MSNs) and dopamine DRD2-expressing (D2 are the principal projection in striatum, which is divided into dorsal striatum (caudate nucleus putamen) ventral (nucleus accumbens olfactory tubercle). Progenitors of these arise lateral ganglionic eminence (LGE). Using conditional deletion, we show that mice lacking transcription factor genes Sp8 Sp9 lose virtually all D2 MSNs as a result reduced neurogenesis LGE, whereas D1 largely...
Abstract Hydrogel scaffolding of stem cells is a promising strategy to overcome initial cell loss and manipulate function post‐transplantation. Matrix degradation requirement for downstream differentiation functional tissue integration, which determines therapeutic outcome. Therefore, monitoring hydrogel essential scaffolded replacement therapies. It shown here that chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) can be used as label‐free platform the crosslinked...
Wavefield extrapolation in pseudoacoustic orthorhombic anisotropic media suffers from wave-mode coupling and stability limitations the parameter range. We use dispersion relation for scalar wave propagation to model acoustic wavefields. The wavenumber-domain application of Laplacian operator allows us propagate P-waves exclusively, without imposing any conditions on range stability. It also avoid artifacts commonly associated with evaluating space domain using practical finite-difference...
// Yan Bai 1,* , Yusong Lin 2,* Wei Zhang 3 Lingfei Kong 4 Lifu Wang Panli Zuo 5 Ignacio Vallines 6 Benjamin Schmitt 7 Jie Tian 8 Xiaolei Song 9 Jinyuan Zhou and Meiyun 1 Department of Radiology, Zhengzhou University People's Hospital & Henan Provincial Hospital, Zhengzhou, Henan, China 2 Cooperative Innovation Center Internet Healthcare School Software Applied Technology, University, Ren Ji Shanghai Jiao Tong Shanghai, Pathology, MR Collaborations NE Asia, Siemens China, Beijing, Imaging...
A series of intra‐molecular hydrogen bonded imidazoles and related heterocyclic compounds were screened for their N–H chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) contrast properties. Of the compounds, imidazole‐4,5‐dicarboxamides (I45DCs) found to provide strongest contrast, with produced at a large shift from water (7.8 ppm) strongly dependent on pH. We have tested several probes based this scaffold, demonstrated that these could be applied in vivo...
Chemical exchange saturation transfer (CEST) is a novel MRI contrast mechanism that well suited for imaging, however, existing small molecule CEST agents suffer from low sensitivity. We have developed salicylic acid conjugated dendrimers as versatile, high performance nanoplatform. In particular, we prepared nanocarriers based on generation 5-poly(amidoamine) (PAMAM) with covalently attached to their surface. The resulting conjugates produce strong 9.4 ppm water the proton tunable ∼1000 s–1...
We introduce a novel technique for seismic wave extrapolation in time. The involves cascading Fourier transform operator and finite-difference to form chain operator: finite differences (FFD). derive the FFD from pseudoanalytical solution of acoustic equation. Two-dimensional synthetic examples demonstrate that can have high accuracy stability complex-velocity media. Applying method anisotropic case overcomes some disadvantages other methods, such as coupling qP-waves qSV-waves. be applied...
Abstract Chemical exchange saturation transfer MRI is a promising new technique for cellular and molecular imaging. This contrast allows the detection of tumors ischemia without use gadolinium as well design microenvironment‐sensitive probes that can be discriminated based on their properties frequency. Current acquisition schemes to detect analyze this suffer from sensitivity spatial B 0 inhomogeneity low contrast‐to‐noise‐ratio, which an obstacle widespread adoption technology. A method...
Abstract The optimal exchange properties for chemical saturation transfer (CEST) contrast agents on 3 T clinical scanners were characterized using continuous wave transfer, and it was demonstrated that the exchangeable protons in phenols can be tuned to reach these criteria through proper ring substitution. Systematic modification allows shift of positioned between 4.8 12 ppm from water enables adjustment proton rate maximize CEST at shifts. In particular, 44 hydrogen‐bonded are investigated...