A5102001895- RNA modifications and cancer
- Extracellular vesicles in disease
- Ferroptosis and cancer prognosis
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Psoriasis: Treatment and Pathogenesis
- T-cell and B-cell Immunology
- Cancer Genomics and Diagnostics
- Immune cells in cancer
- Spinal Cord Injury Research
- Intermetallics and Advanced Alloy Properties
- Epigenetics and DNA Methylation
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Dermatology and Skin Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Electromagnetic wave absorption materials
- RNA Interference and Gene Delivery
- Cancer, Hypoxia, and Metabolism
- interferon and immune responses
- Aluminum Alloys Composites Properties
- Advancements in Transdermal Drug Delivery
- Intracerebral and Subarachnoid Hemorrhage Research
- Nerve injury and regeneration
- Histone Deacetylase Inhibitors Research
Zhuhai People's Hospital
2020-2025
Jinan University
2016-2025
First Affiliated Hospital of Jinan University
2018-2024
Translational Research Institute
2024
Soochow University
2022-2023
Huazhong Agricultural University
2020-2023
Qingdao University
2019
Affiliated Hospital of Qingdao University
2019
Chinese Academy of Medical Sciences & Peking Union Medical College
2014
Imperial College London
2006
Spinal cord regeneration after a spinal injury (SCI) remains difficult challenge due to the complicated inflammatory microenvironment and neuronal damage at sites. In this study, retinoic acid (RA) curcumin (Cur) were co-loaded with bovine serum albumin (BSA) self-assembly obtain RA@BSA@Cur nanoparticles (NPs) for SCI treatment. Cur, as an antioxidant drug, facilitated reactive oxygen species (ROS) scavenging, decreased amount of factors secreted by macrophages, while RA could enhance...
Transplantation of neural stem cells (NSCs) has been proved to promote functional rehabilitation brain lesions including ischemic stroke. However, the therapeutic effects NSC transplantation are limited by low survival and differentiation rates NSCs due harsh environment in after Here, we employed derived from human induced pluripotent together with exosomes extracted treat cerebral ischemia middle artery occlusion/reperfusion mice. The results showed that NSC-derived significantly reduced...
Adipose-resident T cells play a crucial role in the development of obesity-induced insulin resistance. However, specific mechanisms, particularly those involving non-immune cytokines, remain unclear. Here, we report significantly elevated levels sclerostin domain-containing protein 1 (SOSTDC1) individuals with type 2 diabetes (T2D), showing positive correlations fasting glucose and HbA1c. cell-specific Sostdc1-deficient mice exhibit resistance to age-induced adipose lipid accumulation...
Three dimeric nitrophenyl trans-epoxyamides, chrysamides A–C (1–3), were obtained from the deep-sea-derived fungus Penicillium chrysogenum SCSIO41001. Their structures characterized by spectroscopic analysis, electronic circular dichroism computations, and X-ray single-crystal diffraction analysis. Notably, compound 1 possesses a novel centrosymmetric dimer skeleton featuring an unprecedented 7-oxa-2,5-diazabicyclo[2.2.1]heptane ring system, which represents first example of trans-epoxyamide...
Hypoxia-inducible factor 2α (HIF2α) plays a pivotal role in breast tumor growth and metastasis. However, the regulatory mechanisms of HIF2α protein stability remain poorly understood. The precise deubiquitinase (DUB) ubiquitin-specific peptidase 5 (USP5) cancer underlying mechanism remains largely unknown. Here, we identified USP5 as novel DUB for HIF2α. Physically, interacts with protects from ubiquitin-proteasome degradation, thereby promoting transcription target genes, such SLC2A1,...
Abstract Intracerebral hemorrhage (ICH) remains a significant cause of morbidity and mortality around the world, surgery is still most direct effective way to remove ICH. However, potential risks brought by surgery, such as normal brain tissue damage, post‐operative infection, difficulty in removing deep hematoma, are main problems surgical treatment Activation peroxisome proliferator‐activated receptor gamma (PPARγ) reported show good therapeutic effect hematoma clearance. Herein, magnetic...
Abstract γδ T cells play a critical role in early anti-tumor immunity and perform cytotoxicity via NKG2D for recognition multiple cytotoxic factors tumor killing. Recent studies have demonstrated pivotal roles of mTOR-mediated metabolism the maturation, differentiation, effector function diverse immune cells, including DCs, NK CD4+ cell subsets, CD8+ but mTOR signaling is barely known. Here, we showed that suppressing vitro-expanded Vγ4 mechanistic inhibitor rapamycin enhanced their against...
Recent studies have shown that PPP1R14B was highly expressed in tumor tissues and patients with high expression of had poor survival rates. However, the function mechanisms progression remain ill defined. There also lack pan-cancer evidence for relationship between various types based on abundant clinical data. We used TCGA project GEO databases to perform analysis PPP1R14B, including differences, correlations levels survival, genetic alteration, immune infiltration, relevant cellular...
Amino acid (aa) metabolism is closely correlated with the pathogenesis of psoriasis; however, details on aa transportation during this process are barely known. Here, we find that SLC38A5, a sodium-dependent neutral transporter counter-transports protons, markedly upregulated in psoriatic skin both human patients and mouse models. SLC38A5 deficiency significantly ameliorates psoriasis, indicating pathogenic role SLC38A5. Surprisingly, almost exclusively expressed dendritic cells (DCs) when...
Zika virus (ZIKV) is a member of the Flaviviridae family and causes congenital microcephaly Guillain–Barré syndrome. Currently, there lack approved vaccines or therapies against ZIKV infection. In this study, we profile vRNA‒host protein interactomes at stem‒loop B (SLB) reveal that interleukin enhancer binding factor 3 (ILF3) DEAH-box helicase 9 (DHX9) form positive regulators antiviral RNA inference in undifferentiated human neuroblastoma cells induced pluripotent stem cell-derived neural...
Three stochastic models of genomic instability recently developed by Little and Wright ( Math. Biosci ., (2003) 183, 111–34), with two, three five stages, the two-stage model Nowak et al. Proc. Natl Acad. Sci. USA , (2002) 99, 16226–16231) are compared four-stage proposed Luebeck Moolgavkar 15095–15100) that does not assume such an mechanism. All fitted to US colon cancer incidence data. The best fitting Wright, markedly inferior. fits three-stage five-stage somewhat worse P < 0.05),...
Psoriasis is a systemic inflammatory disease, and the mechanism that links psoriasis to depression still elusive. Hence, this study aimed elucidate potential pathogenesis of comorbidity.The gene expression profiles (GSE34248, GSE78097 GSE161683) (GSE39653) were downloaded from Gene Expression Omnibus (GEO) DataSets. Functional annotation, protein-protein interaction (PPI) network module construction, hub identification co-expression analysis performed, following common differentially...
Abstract SLMO2 is a lipid transporter that transports phosphatidylserine to the interior of mitochondria, also known as PRELID3B, which plays an important role in metabolism. It has been reported be involved growth process breast and lung tumors. However, its functions underlying mechanisms cancer progress remain elusive, potential pan-cancer biomarker therapeutic target remains unexplored. Using TCGA project GEO database, we performed analysis SLMO2, including expression pattern, prognostic...