A5101968307- Immune Cell Function and Interaction
- Metabolism, Diabetes, and Cancer
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Pediatric health and respiratory diseases
- Diabetes and associated disorders
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Robot Manipulation and Learning
- Gut microbiota and health
- Hepatitis B Virus Studies
- Circular RNAs in diseases
- Advanced Control Systems Optimization
- Asthma and respiratory diseases
- Video Analysis and Summarization
- Retinal Diseases and Treatments
- MicroRNA in disease regulation
- Hippo pathway signaling and YAP/TAZ
- International Student and Expatriate Challenges
- Complement system in diseases
- Advanced Data and IoT Technologies
- Big Data and Digital Economy
Shanghai University of Traditional Chinese Medicine
2017-2025
Peking University
2015-2025
Center for Interdisciplinary Studies
2025
Shandong University
2024
Tianjin Medical University
2019-2024
First Affiliated Hospital of Harbin Medical University
2022-2024
Bengbu Medical College
2024
Harbin Medical University
2022-2024
Anhui Medical University
2023
First Affiliated Hospital of Anhui Medical University
2023
Hyperuricemia (HUA) is a metabolic disease characterized by elevated serum uric acid (SUA).Empagliflozin, kind of sodium-glucose cotransporter 2 inhibitors, has recently emerged as new antidiabetic agent facilitating glucose excretion in urine.Moreover, there was evidence SUA reduction following treatment with empagliflozin addition to glycaemic control, while the molecular mechanisms remain unknown.To investigate potential mechanisms, model type diabetes (T2DM) HUA established combination...
Introduction: It is known that the metabolic disorder caused by high glucose one of pathogenesis in diabetic retinopathy (DR), leading cause blindness, due to main pathological change apoptosis endothelial cells (ECs). In previous studies, potential impact sodium cotransporter-2 (SGLT-2), whose inhibitors slow progression DR, has not been elucidated. The purpose presented study was explore effect SGLT-2 dapagliflozin (DAPA) on mice retina and human retinal microvascular (HRMECs), examine...
Many studies have shown that tissue kallikrein has effects on diabetic vascular complications such as nephropathy, cardiomyopathy and neuropathy, but its retinopathy are not fully understood. Here, we investigated the retinoprotective role of exogenous pancreatic studied potential mechanisms action. We used KK Cg-Ay/J (KKAy) mice (a mouse model spontaneous type 2 diabetes) with high-fat diet/streptozotocin (STZ)-induced diabetes our models. After onset diabetes, both types were injected...
A growing number of studies have demonstrated that the activity and expression level sirtuin-1 (SIRT1) are decreased in asthma patients; however, mechanisms underlying SIRT1 function still not completely understood. Interleukin (IL)-6 plays important roles inflammation during allergic asthma. In this study, we examined whether loss regulated IL-6 further verified mechanisms.The human airway epithelial cell line 16HBE was used to test effects inhibitor (salermide) on IL-6. mRNA protein were...
Ageing is often accompanied with a decline in immune system function, resulting ageing. Numerous studies have focussed on the changes different lymphocyte subsets diseases and immunosenescence. The change phenotype key indication of diseased or healthy status. However, number brought about by ageing not been comprehensively analysed. Here, we analysed T natural killer (NK) cell subsets, differentiation states 43,096 individuals, aged 20-88 years, without known diseases. Thirty-six parameters...
Steatosis is an important clinical manifestation associated with chronic hepatitis C virus (HCV) infection. AMP-activated protein kinase (AMPK), a major mediator of lipid metabolism, regulates HCV-associated hepatic steatosis, but the underlying mechanisms remain obscure. Here we investigated mechanism HCV nonstructural 5A (NS5A)-induced accumulation by AMPK/SREBP-1c pathway.We generated model mice injecting recombinant lentiviral particles expressing NS5A (genotype 3a) via tail vein. The...
The intricate relationship between human health and gut microecology has emerged as a central theme in contemporary medical research. Postmenopausal osteoporosis, primarily driven by estrogen deficiency, remains major concern. Traditional Chinese herbal medicines have attracted significant interest for their promising role osteoporosis treatment. effects of Isaria felina, derived from Cordyceps sinensis, on postmenopausal rats are the focus this study. Adult female Sprague-Dawley were...
Abstract The recently discovered long‐range topological spin textures exhibit spontaneous Hall effects, which offer a breakthrough solution to the challenge of write‐in and readout information in antiferromagnets. Despite this advancement, implementation such magnetic orders single‐crystal nanoflakes remains limited, can otherwise enhance design flexibility heterostructures open new possibilities for next‐generation ultracompact, high‐speed, low‐power spintronic devices. Here, air‐stable...
Abstract γδ T cells play a critical role in early anti-tumor immunity and perform cytotoxicity via NKG2D for recognition multiple cytotoxic factors tumor killing. Recent studies have demonstrated pivotal roles of mTOR-mediated metabolism the maturation, differentiation, effector function diverse immune cells, including DCs, NK CD4+ cell subsets, CD8+ but mTOR signaling is barely known. Here, we showed that suppressing vitro-expanded Vγ4 mechanistic inhibitor rapamycin enhanced their against...
Lung squamous cell carcinoma is a common histological lung cancer subtype, but unlike adenocarcinoma, limited therapeutic options are available for treatment. Curcumin, natural compound, may have anti-cancer effects in various cells, how it be used to treat has not been well studied. Here, we applied curcumin human NCI-H292 line test and explored underlying potential mechanisms of action. Curcumin treatment inhibited growth increased FOXA2 expression time-dependent manner. was decreased...
Two-dimensional (2D) van der Waals (vdW) dielectrics with high-κ and anisotropy are crucial for advanced field-effect transistors (FETs) other anisotropic electronic devices. Here, we demonstrate a 2D vdW dielectric, Bi2TeO5, that uniquely combines pronounced anisotropy. By adjusting the precursor mass during chemical vapor deposition, can controllably synthesize Bi2TeO5 orientations ranging from in-plane to out-of-plane. As dielectric in MoS2 top-gate FETs, achieves Ion/Ioff exceeding 107,...
Abstract This study evaluated the effectiveness of metagenomic next-generation sequencing (mNGS) in detecting pathogens patients with pulmonary infections, comparing a low-data-volume, human-depleted quantitative (Q) method and high-data-volume, non-human-depleted pathogen capture engine (PACE) method. A total 133 were enrolled, comprising 59 control group (traditional culture) 74 an mNGS (51 Q 23 PACE). Bronchoalveolar lavage fluid samples collected for detection. Mycobacterium tuberculosis...
Epidemiological data provide strong evidence of dramatically increasing incidences many autoimmune diseases in the past few decades, mainly western and westernized countries. Recent studies clearly revealed that 'Western diet' increases risk at least partially via disrupting intestinal tight junctions altering construction metabolites microbiota. However, role high sucrose cola beverages (HSCBs), which are one main sources added sugar diet, is barely known. Recently, a population study...
Adenosine receptor A2B ( ADORA2B ) encodes a protein belonging to the G protein–coupled superfamily. Abnormal expression of may play pathophysiological role in some human cancers. We investigated whether is potential diagnostic and prognostic biomarker for lung adenocarcinoma (LUAD). The expression, various mutations, copy number variations, mRNA levels, related network signaling pathways were analyzed using bioinformatics-related websites, including Oncomine, UALCAN, cBioPortal, GeneMANIA,...
Increases in glucose production and decreases hepatic glycogen storage induce metabolic abnormalities type 2 diabetes (T2DM). Empagliflozin, a sodium-dependent transporter (SGLT2) inhibitor, is an effective hypoglycemic drug; however, the effects of empagliflozin on gluconeogenesis glycogenesis are still unclear. In this study, we investigated mechanisms vivo vitro. Empagliflozin was administered via gavage to db/db mice for 8 weeks, human hepatocyte HL7702 cells were treated with after...
Hepatitis B virus surface antigen (HBsAg) carriers are highly susceptible to liver injury triggered by environmental biochemical stimulation. Previously, we have reported an inverse correlation between γδ T cells and damage in patients with hepatitis (HBV). However, whether play a role regulating the hypersensitivity of HBsAg stimulation-induced is unknown. In this study, using HBV transgenic (HBs-Tg) HBs-Tg T-cell receptor-δ-deficient (TCR-δ-/- ) mice, found that mice genetically deficient...
The use of particulate adjuvants offers an interesting method for enhancing and modulating the immune responses elicited by vaccines. Aluminum salt (Alum) is one most important approved Food Drug Administration in humans because its safety efficacy, but it lacks capacity to induce strong cellular mucosal responses. In this study, we designed antigen delivery system that combines aluminum salts with β-glucan particles. β-glucan-aluminum particles (GP-Al) exhibited a highly uniform size 2–4 μm...
Introduction We aimed to evaluated the effect of premixed insulin (Ins), combined with metformin (Ins+Met) or mulberry twig alkaloids(Ins+SZ-A) on blood glucose fluctuations in patients type 2 diabetes (T2DM) using continuous monitors (CGM). Methods Thirty T2DM and poor control drugs were for eligibility during screening period. Subsequently, their original hypoglycemic discontinued lead-in period, after receiving Ins intensive treatment weeks, they randomly assigned receive either Ins,...
Sesamin is a lignan compound in plants that has various pharmacological effects, including reducing diabetes-associated injuries, regulating fatty acid and cholesterol metabolism, exerting antiinflammatory antitumour effects. Previous studies have reported sesamin can inhibit the proliferation of several types tumour cells exert However, effect on T-cell lymphoma still unknown. In this study, we selected mouse model to investigate mechanism against via programmed cell death vivo vitro. We...
This study aimed to investigate the diagnostic value of total amino-terminal propeptide type 1 procollagen (P1NP) and C-terminal telopeptide β-I collagen (β-CTX) in bone metastasis patients with breast cancer correlation between them.The medical records 73 were retrospectively analyzed. These treated Oncology, General Surgery, Orthopedic Departments The Third People's Hospital Qingdao from March 2014 April 2017, including 40 (bone group) 33 no (non-bone group). Other healthy people who...