A5101813644- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Intraocular Surgery and Lenses
- Retinal and Optic Conditions
- Retinal and Macular Surgery
- Ocular Infections and Treatments
- Retinopathy of Prematurity Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Pituitary Gland Disorders and Treatments
- Ocular Surface and Contact Lens
- Antifungal resistance and susceptibility
- Brain Tumor Detection and Classification
- Ophthalmology and Visual Impairment Studies
- Optical Coherence Tomography Applications
- Single-cell and spatial transcriptomics
- Complement system in diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood Coagulation and Thrombosis Mechanisms
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- Renal and Vascular Pathologies
- Intracranial Aneurysms: Treatment and Complications
- Urticaria and Related Conditions
Tianjin Medical University
2010-2025
Second Hospital of Tianjin Medical University
2017-2022
Narayana Nethralaya
2022
Tianjin Medical University Eye Hospital
2009-2015
Tianjin Children's Hospital
2015
To evaluate the role, safety, and effectiveness of intravitreal conbercept (KH902) injections as an adjunct to vitrectomy in management severe proliferative diabetic retinopathy.A randomized controlled trial was performed on 36 eyes patients affected by vitreous hemorrhage tractional retinal detachment, which occurred a consequence active retinopathy. The were randomly assigned two groups. one groups received injection inferior temporal sector 4 mm from sclerocorneal limbus with sterile...
Many studies have shown that tissue kallikrein has effects on diabetic vascular complications such as nephropathy, cardiomyopathy and neuropathy, but its retinopathy are not fully understood. Here, we investigated the retinoprotective role of exogenous pancreatic studied potential mechanisms action. We used KK Cg-Ay/J (KKAy) mice (a mouse model spontaneous type 2 diabetes) with high-fat diet/streptozotocin (STZ)-induced diabetes our models. After onset diabetes, both types were injected...
This study was to explore the mechanism by which reactive oxygen species (ROS)-induced oxidative stress involved in pathogenesis of fungal keratitis using an vivo experimental mouse model and vitro culture human corneal epithelial cells (HCECs). Compared normal control mice HCECs, ROS production markedly increased corneas HCECs exposed Candida albicans, accompanied p38 mitogen-activated protein kinases (MAPK) activation. Increased products markers, malondialdehyde (MDA), 4-hydroxynonenal...
Abnormal angiogenesis is a key process associated with ischaemic retinopathies such as diabetic retinopathy, for which the underlying pathological mechanisms are still poorly understood. Here, we confirm that angiogenic factor 1 G patch and FHA domain (AGGF1) elevated in diabetics induces retinal angiogenesis. Mechanistic investigations demonstrate HIF-1α directly regulates AGGF1 expression. upregulates expression of cell cycle proteins by increasing binding tumour necrosis ligand...
Proliferative Diabetic Retinopathy (PDR) is a chronic complication of Diabetes and the main cause blindness among world’s working population at present. While there have been many studies on pathogenesis PDR, its intrinsic molecular mechanisms not yet fully elucidated. In recent years, several employed bulk RNA-sequencing (RNA-seq) single-cell RNA sequencing (scRNA-seq) to profile differentially expressed genes (DEGs) cellular components associated with PDR. This study adds this expanding...
The recent advancement in the management of chronic renal failure (CRF) has significantly increased longevity patients, which increase incidence severe vitreoretinopathy. vitrectomy is highly risky this particular group patients due to their systemic comorbidity. timing surgical intervention usually delayed because conditions. This study evaluate safety and effectiveness 25-guage for vitreoretinopathy CRF patients.In retrospective study, 16 eyes with were undergone department Ophthalmology...
Narrower retinal arterioles and wider venules have been associated with the incidence of heart failure (HF). However, whether they are predictive prognosis (HF) is unclear. We aimed to explore role vessel calibers in predicting long-term clinical outcomes HF.This a prospective, single-center, observational study that surveyed patients tertiary referral hospital for treatment HF. Retinal caliber was graded using photography. The primary endpoint composite HF rehospitalization mortality at 12...
Abstract Background To analyze the related factors of visual acuity after phacoemulsification and intraocular lens implantation in chronic renal failure (CRF) patients. Methods We retrospectively analyzed 42 patients (51 eyes) with CRF (failure, uremia) on hemodialysis or peritoneal dialysis 40 (50 without as a control group. Each individual underwent physical laboratory examinations including best corrected (BCVA), slit lamp examination, pressure, corneal endothelial cell count, fundus...
This paper addresses an automatic detection method of microaneurysms in color fundus images, which plays a key role computer assisted diagnosis diabetic retinopathy, serious and frequent eye disease. The main concentration this is to detect with phase congruency. first step consists image normalization green channel extraction. second aims at obtaining candidate regions, achieved using Then the irrelevant information, such as vessel fragments, removed by constructing directional...
Background To suppress vascular endothelial growth factor (VEGF) is a researching hot topic for the treatment and prevention of retinal neovascularization.Some detectable efficacy VEGF small interference RNA (VEGF siRNA) in anti-tumor neovascularization has been well-known.But relevant study on siRNA seldom.Objective Present was to investigate inhibiting effect neovascularization.Methods The 48 clean C57BL/6J mice aged 7-day-old were randomly divided into normoxia group,hypoxia control...
Objective To investigate and evaluate the densities morphological changes to find out characteristics change of corneal endothelium in different stages PDR(proliferative diabetic retinopathy)patients after vitreous retinal surgeries with confocal microscope.Methods In our study,56 eyes 49 patients vitreoretinal diseases who underwent were analyzed,including 35 29 suffer from PDR.All examined by microscope before 1 week,1 month 3 months surgery.Corneal endothelial cell densities,the...
Objective To analyze retraspectively the effect of combined phacoemulsification with modified trabeculectomy.Methods A retrospective analysis was performed on 95 eyes 79 patients and trabeculectomy from January 2005 to April 2008.Then procedure started as a one-site approach through short scleral tunnel incision.All surgeries were by one surgeon.To test best corrected visual acuity(BCVA),introcular pressure,and complications at 1 day,1 week,1 month,3 months after surgery.Results Follow-up...