A5103107974- RNA modifications and cancer
- Metal-Catalyzed Oxygenation Mechanisms
- Advanced Glycation End Products research
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer-related Molecular Pathways
- DNA Repair Mechanisms
- HER2/EGFR in Cancer Research
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Glycosylation and Glycoproteins Research
- Ubiquitin and proteasome pathways
- Immune cells in cancer
- Cholesterol and Lipid Metabolism
- Colorectal and Anal Carcinomas
- Fatty Acid Research and Health
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Plant Pathogens and Fungal Diseases
- Gastrointestinal motility and disorders
- Gut microbiota and health
- RNA Interference and Gene Delivery
- Clinical Nutrition and Gastroenterology
- Heme Oxygenase-1 and Carbon Monoxide
- Crystal structures of chemical compounds
- Molecular Sensors and Ion Detection
Shenzhen Polytechnic
2024
Jinan University
2020-2023
Nanjing Polytechnic Institute
2020
University of Aberdeen
2020
Shanghai First People's Hospital
2013-2018
Shanghai Jiao Tong University
2012-2018
The University of Texas MD Anderson Cancer Center
2014
Southwest Medical University
2007
Abstract Tumor repopulation during therapy is an important cause of treatment failure. Strategies to overcome are arising in parallel with advances the comprehension underlying biological mechanisms. Here, we reveal a new mechanism by which high mobility group box 1 (HMGB1) released dying cells radiotherapy or chemotherapy could stimulate living tumor cell proliferationInhibition genetic ablation HMGB1 suppressed proliferation. This effect was due binding HMGB1with member receptor for...
Dying tumor cells after irradiation could promote the proliferation of living might cause relapse and treatment failure. Our previous study showed that activated caspase-3 probably participates in repopulation. In this study, we investigated whether high mobility group box 1(HMGB1) is also involved Colorectal were irradiated. The cleaved (CC3) irradiated HMGB1 supernatant detected by Western blot. A large number colorectal (feeder cells) then co-cultured with a small luciferase-labeled...
Ribonucleotide reductase (RNR) is the key enzyme that catalyzes production of deoxyribonucleotides (dNTPs) for DNA replication and it also essential cancer cell proliferation. As RNR inhibitor, Gemcitabine widely used in therapies, however, resistance limits its therapeutic efficacy curative potential. Here, we identified mTORC2 a main driver gemcitabine non-small lung cancers (NSCLC). Pharmacological or genetic inhibition greatly enhanced induced cytotoxicity damage. Mechanistically,...
Objective: To evaluate the risk factors of coloanal anastomotic stricture after laparoscopic intersphincteric resection (Lap-ISR) for patients with low rectal cancer. Methods: A retrospective case-control study was performed to collect clinicopathological data from a prospective database (registration number: ChiCTR-ONC-15007506) at Department Colorectal Surgery, Characteristic Medical center PLA Rocket Force. From June 2011 August 2018, total 144 consecutive cancer who underwent Lap-ISR...
Introduction Grape is of high economic value. Colletotrichum viniferum , a pathogen causing grape ripe rot and leaf spot, threatens production quality. Methods This study investigates the interplay between C. by Cytological transcriptome sequencing. Results Different grapevine germplasms, V. vinifera cv. Thompson Seedless (TS), labrusca accession Beaumont (B) piasezkii Liuba-8 (LB-8) were classified as highly sensitive, moderate resistant to respectively. analysis reveals distinct...
In the title compound, C 29 H 25 FN 2 O 4 , mean planes of indole ring systems are approximately perpendicular to one another [dihedral angle = 88.3 (4)°]. The benzene is twisted with respect by 49.8 (5) and 77.6 (3)°. crystal, pairs N—H...O hydrogen bonds link molecules into inversion dimers which further linked supramolecular chains propagating along [110] direction.
Abstract Her2 positive (Her2+) breast cancer (BC) accounts for 20% of all subtypes and is associated with high risk death. Trastuzumab (Ttzm), first FDA-approved targeted therapy BC, represents a key milestone in the personalized treatment Her2+ metastatic disease (MBC). However, 75% MBC are or become resistant to Ttzm experience relapse progression. This suggests that tumors acquire possess an intrinsic mechanism resistance prevents from inhibition. Therefore, it important identify novel...