A5024051725- Mesenchymal stem cell research
- Phytochemicals and Antioxidant Activities
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- Bioactive Compounds in Plants
- Cancer Cells and Metastasis
- Ginger and Zingiberaceae research
- Platelet Disorders and Treatments
- Cell death mechanisms and regulation
- Plant biochemistry and biosynthesis
- Fungal Biology and Applications
- Lung Cancer Treatments and Mutations
- Traditional Chinese Medicine Studies
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Genomics, phytochemicals, and oxidative stress
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Food composition and properties
- Cancer Risks and Factors
- Effects of Radiation Exposure
- Proteins in Food Systems
- Cancer-related Molecular Pathways
Tianjin University of Commerce
2016-2025
The University of Texas MD Anderson Cancer Center
2024-2025
Qujing Normal University
2025
Dazhou Academy of Agricultural Sciences
2025
Anhui Medical University
2012-2024
Shantou University Medical College
2024
Shantou University
2024
Ministry of Education of the People's Republic of China
2024
Chinese PLA General Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
1999-2024
Transplantation of mesenchymal stem cells (MSCs) has been used to treat a wide range diseases, and the mechanism action is postulated be mediated by either differentiation into functional reparative that replace injured tissues or secretion paracrine factors promote tissue repair. To complement earlier studies identified some factors, we profiled proteome better assess relevance MSC spectrum MSC-mediated therapeutic effects. evaluate potential proteome, chemically defined serum-free culture...
Abstract Objectives: The aim of this study was to explore the profile and function CD4 + CD25 regulatory T cells (Treg cells) in idiopathic thrombocytopenic purpura (ITP) patients. Methods: Treg cell numbers were analyzed by flow cytometric analysis peripheral blood mononuclear collected from healthy donors or patients with ITP. Quantification proliferation assayed an enzyme‐linked immunosorbent assay kit, based on measurement BrdU incorporation during DNA synthesis. Results: percentage...
Citrus is a kind of common fruit and contains multiple beneficial nutrients for human beings. Flavonoids, as class plant secondary metabolites, exist in citrus fruits abundantly. Due to their broad range pharmacological properties, flavonoids have gained increased attention. Accumulative vitro vivo studies indicate protective effects polymethoxyflavones (PMFs) against the occurrence cancer. PMFs inhibit carcinogenesis by mechanisms like blocking metastasis cascade, inhibition cancer cell...
Circular RNAs (circRNAs) are a class of endogenous noncoding that have been demonstrated to be potential regulators in the development and progression various types human cancer. However, little is known about their roles cancer initiation progression, particular non‑small cell lung (NSCLC). In present study, expression level circRNA‑forkhead box O3 (FOXO3) NSCLC specimens was determined its functional role investigated cells. By performing Taq‑man based RT‑qPCR, it identified circRNA‑FOXO3...
Abstract The loss of stem cells residing in the base intestinal crypt has a key role radiation-induced injury. In particular, Lgr5 + (ISCs) are indispensable for regeneration following exposure to radiation. Mesenchymal (MSCs) have previously been shown improve epithelial repair mouse model radiation injury, and, therefore, it was hypothesized that this protective effect is related ISCs. study, found that, radiation, transplantation MSCs improved survival mice, ameliorated injury and...
Stem cell factor (SCF) plays important roles in tumor growth and angiogenesis. However, its regulatory mechanism remains largely undefined. Here, we report that hypoxia upregulated the expression of SCF MCF-7 breast cancer cells both messenger RNA protein levels. When hypoxia-inducible (HIF)-1α was knocked down by interference, decreased significantly. Furthermore, receptor, c-kit phosphorylation significantly strengthened condition culture media from hypoxic MCF-7-c cells. The survival A549...
Background: CD151 is highly expressed in breast cancer cells and has been shown to accelerate by enhancing cell growth motility, but its regulation poorly understood. To explore post-translation of CD151, for example microRNAs, will be great importance claim the mechanism. Methods: A luciferase reporter assay was used determine whether a target miR-124. The levels mRNA were detected real-time PCR protein expression measured western blot flow cytometry. effects miR-124 on growth, apoptosis,...
In addition to serving as a prosthetic group for enzymes and hemoglobin structural component, heme is crucial homeostatic regulator of erythroid cell development function. While lncRNAs modulate diverse physiological pathological cellular processes, their involvement in heme-dependent mechanisms largely unexplored. this study, we elucidated lncRNA (UCA1)-mediated mechanism that regulates metabolism human cells. We discovered UCA1 expression dynamically regulated during maturation, with...
Aging and oxidative-related events are closely associated with the oxidative damages induced by excess reactive oxygen species (ROS). The phytochemicals nobiletin (NBT) tangeretin (TAN) their 5-demethylated derivatives 5-demethylnobiletin (5-DN) 5-demethyltangeretin (5-DT) representative polymethoxyflavone (PMF) compounds found in aged citrus peels. Although health benefits from PMFs due to antioxidant activities have been well documented, a systematic assessment regarding antioxidation...
Oxidative stress leads to various diseases, including diabetes, cardiovascular neurodegenerative and even cancer. The dietary flavonol glycoside, hyperoside (quercetin-3-O-galactoside), exerts health benefits by preventing oxidative damage. To further understand its antioxidative defence mechanisms, we systemically investigated the regulation of on damage induced hydrogen peroxide, carbon tetrachloride, cadmium in Saccharomyces cerevisiae. Hyperoside significantly increased cell viability,...
The intestinal barrier plays a central role in sustaining gut homeostasis and, when dysfunctional, may contribute to diseases. Dietary flavonoids derived from Citrus genus represent one of the main naturally occurring phytochemicals with multiple potential benefits for function. In intestine, citrus (CFs) undergo ingestion lumen, biotransformation epithelial cells and/or crosstalk luminal microbiota afford various metabolites that turn exert protective actions on along their parental...