A5074469361- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Pluripotent Stem Cells Research
- Mesenchymal stem cell research
- Cardiac and Coronary Surgery Techniques
- Congenital Heart Disease Studies
- Tissue Engineering and Regenerative Medicine
- Infective Endocarditis Diagnosis and Management
- Mechanical Circulatory Support Devices
- Cardiac Ischemia and Reperfusion
- Surgical site infection prevention
- Reconstructive Surgery and Microvascular Techniques
- Cardiovascular Effects of Exercise
- Cardiac Arrhythmias and Treatments
- Cardiac Imaging and Diagnostics
- Healthcare Systems and Reforms
- Coronary Artery Anomalies
- Vascular anomalies and interventions
- Pericarditis and Cardiac Tamponade
- Orthopedic Infections and Treatments
- Organ Transplantation Techniques and Outcomes
- Angiogenesis and VEGF in Cancer
- Cardiomyopathy and Myosin Studies
- Cardiac, Anesthesia and Surgical Outcomes
Libyan International Medical University
2010-2025
University of Tripoli
2016
University of Benghazi
2010-2011
National University of Singapore
2001-2010
Prince Sultan University
1999-2009
University of Michigan
2008
Goethe University Frankfurt
2008
Duke-NUS Medical School
2008
Saudi Heart Association
2007
National University Hospital
1999-2006
Abstract Adult tissue-derived mesenchymal stem cells (MSCs) have demonstrated therapeutic efficacy in treating diseases or repairing damaged tissues through mechanisms thought to be mediated by either cell replacement secretion of paracrine factors. Characterized, self-renewing human ESCs could potentially an invariable source consistently uniform MSCs for applications. Here we describe a clinically relevant and reproducible manner generating identical batches hESC-derived MSC (hESC-MSC)...
Transplantation of mesenchymal stem cells (MSCs) has been used to treat a wide range diseases, and the mechanism action is postulated be mediated by either differentiation into functional reparative that replace injured tissues or secretion paracrine factors promote tissue repair. To complement earlier studies identified some factors, we profiled proteome better assess relevance MSC spectrum MSC-mediated therapeutic effects. evaluate potential proteome, chemically defined serum-free culture...
This study aimed to test these hypotheses: cystathionine γ-lyase (CSE) is expressed in a human artery, it generates hydrogen sulfide (H<sub>2</sub>S), and H<sub>2</sub>S relaxes artery. produced endogenously rat arteries from cysteine by CSE. Endogenously dilates resistance arteries. Although CSE arteries, its presence blood vessels has not been described. In this study, we showed that both mRNA, determined reverse transcription-polymerase chain reaction, protein, Western blotting,...
The indications and the outcome of surgery for pulmonary aspergilloma remain highly controversial. short term long results lung resection or cavernostomy in 24 patients with are reported.The case notes 27 consecutive referred surgical assessment at Royal Brompton Hospital over last 14 years were reviewed. Patients categorised into four classes according to their fitness severity symptoms. Severe symptoms defined as life threatening haemoptysis other requiring more than one hospital...
We have reviewed 70 consecutive elderly patients (70 years or older) who underwent pneumonectomy for bronchogenic carcinoma, in order to evaluate morbidity, mortality, and long-term survival. The majority of the had stage II (n = 32) III 25) disease. Fifteen deaths occurred peri-operative period (21%). Pre-operative factors associated with death included a history ischaemic heart disease (P 0.001) right-sided tumour (peri-operative mortality right 37%, left 6%, P 0.001). Poor lung function...
Urotensin II (UII) is a vasoactive peptide that has recently emerged as likely contributor to cardiovascular physiology and pathology. Acute infusion of UII into nonhuman primates results in circulatory collapse death; however, the exact cause death not well understood. This study was undertaken elucidate mechanism underlying fatal event on application vivo primates. To this end, cynomolgus monkeys ( n = 4) were anesthetized tracheal intubation performed. One internal jugular vein cannulated...
The extra demand imposed upon the Libyan health services during and after revolution in 2011 led ailing systems to collapse. To start planning process re-engineer sector, Ministry of Health collaboration with World Organisation (WHO) other international experts field sponsored National Systems Conference Tripoli, Libya, between 26th 30th August 2012. aim this conference was study how function at arena facilitate a consultative 500 order identify problems within system propose potential...
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No abstract available.
Background: We have previously derived highly similar lineage-restricted stem cell lines, RoSH and E-RoSH lines from mouse embryos CD9hi SSEA-1- differentiated embryonic cells, respectively. These are not pluripotent differentiate readily into endothelial cells in vitro vivo.Results: investigated the signaling pathway that maintains proliferation of these an undifferentiated state, demonstrate PI3 K/Akt/mTOR, but Raf/MEK/Erk, was active during downregulated differentiation. Inhibition...
Dyslipidemia, inflammation and gender are major risk factors in cardiovascular disease. Here we show that hepatic expression of Peroxisome proliferator-activated receptor alpha (PPARalpha), a nuclear regulates lipid metabolism inflammation, is regulated gender-specific manner during lipopolysaccharide (LPS)-induced systemic inflammation. Immediately following LPS-induced PPARalpha mRNA level decreased dramatically mice. It was restored to baseline within 24 h females but remained below for...