A5031495796- Respiratory Support and Mechanisms
- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Neuroscience of respiration and sleep
- Adrenal Hormones and Disorders
- Congenital Diaphragmatic Hernia Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Pituitary Gland Disorders and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Veterinary Pharmacology and Anesthesia
- Anesthesia and Pain Management
- Airway Management and Intubation Techniques
- Lipoproteins and Cardiovascular Health
- Pain Mechanisms and Treatments
- Cancer, Hypoxia, and Metabolism
- Hemodynamic Monitoring and Therapy
- Renal function and acid-base balance
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer, Lipids, and Metabolism
- Cardiac Arrest and Resuscitation
- Peripheral Neuropathies and Disorders
Ministry of Health
2025
The Alfred Hospital
2025
Singapore General Hospital
2004-2024
SingHealth
2018-2021
The University of Melbourne
2007
Oxford Centre for Diabetes, Endocrinology and Metabolism
2003
University of Oxford
1988-1993
National Hospital for Neurology and Neurosurgery
1976-1992
University College London
1976-1992
Drexel University
1991-1992
A syndrome of alveolar hypoventilation has been identified in a group patients with bilateral diaphragm paralysis. Eight were studied whom weakness had suggested by paradoxical (inward) movement the abdominal wall on inspiration, seven evidence generalized neuromuscular disorder. Diaphragm function was assessed quantitatively measurement change transdiaphragmatic pressure during maximum inspiration (Δ PDi). In five patients, Δ PDi zero and others ranged from 2–6 cm H2O (normal > 25 H2O)...
In various chronic painful states, the sympathetic nerve supply was blocked either by injecting chain and ganglia with local anaesthesia or injection of guanethidine during occlusion circulation. There a striking relation between presence hyperpathia relief pain blocks. The block unlikely to relieve unless accompanied pain; when present, relieved both constant hyperpathia. effectiveness blocks shows that are maintained emission noradrenaline in periphery. facts related system sensibility discussed.
Respiratory complications occur in advanced multiple sclerosis (MS) but may also complicate acute relapses earlier the disease. We present 19 patients with MS who developed respiratory at a mean of 5.9 (range 1–12) yrs after onset neurological symptoms. Fourteen severe insufficiency presenting combination reduced forced vital capacity (FVC), hypoxaemia or hypercapnia (12 patients) and arrest (four patients). Two presented apneustic breathing, one paroxysmal hyperventilation, obstructive...
Measurements of closing volume have been made in 20 women between the 36th and 40th weeks pregnancy. The patients were studied erect supine positions point airway closure was related to functional residual capacity. results show that occurred during tidal ventilation 10 position six position. These may explain variation found maternal arterial oxygen tension
Although respiratory insufficiency is common in the advanced stages of motor neuron disease, some patients may develop distressing symptoms early course disease or even present with failure arrest. We describe 14 who were considered for support; 11 received such support and all derived significant symptomatic improvement without prolongation life. Of 8 typical features amyotrophic lateral sclerosis, 7 had predominant diaphragm weakness I generalized muscle weakness; negative pressure...
Guanethidine was infused by the regional intravenous technique into upper and lower limbs of patients with painful hyperpathic states, due to peripheral or central lesions. The relief pain hyperpathia occurred within 20 minutes infusion lasted between three 128 hours; in a few patients, has for months. Great reduction skin conductance vasodilatation occurred, there being marked variation time onset duration these effects. In some cases pilo-erection. given this way did not completely block...
Summary Twenty‐four patients (23 male) who presented for aortic reconstructive surgery were studied with pulse oximetry on a pre‐operative night and during the first five postoperative nights. Patients or more dips in oxygen saturation of greater than 4% (with prompt recovery back toward baseline 3% more) per hour monitoring classified as having significant abnormality respiration. Pre‐operatively, four 24 (17%) demonstrated such an abnormality. Postoperatively, 12 (50%) met these criteria...
Eight patients were studied in whom a lesion within the central nervous system caused constant pain and hyperpathia. Blockade of sympathetic supply to periphery was carried out each patient by stellate ganglion block or intravenous infusion guanethidine 15 mg 30 ml saline into limb on affected side. On almost every occasion hypersensitivity reduced, sometimes completely. Thus chronic hyperpathia arising from may be abolished blocking periphery; this effect achieved when not all peripheral...
Prediction models have been developed to predict either unilateral or bilateral primary aldosteronism, and these not validated externally. We aimed develop a simplified score both subtypes validate this externally.Our development cohort was taken from 165 patients who underwent adrenal vein sampling (AVS) in two Asian tertiary centres. Unilateral disease determined using AVS postoperative outcome. Multivariable analysis used construct prediction models. our tool European of 97 enrolled the...
Background Direct oral anticoagulants (DOACs) have been linked to better renal outcomes than warfarin in non-valvular atrial fibrillation (NVAF). We aimed compare the function Asian NVAF patients treated with and DOAC. Methods This multicentre retrospective study analysed newly initiated on anticoagulant (OAC) from 2013 2022 across seven tertiary hospitals. Using propensity-score matching, DOAC recipients were matched by incorporating 22 variables potentially affecting outcomes. Primary...
The Singapore population comprises Chinese, Malays and Asian Indians. Within this population, Indians have the highest rates of coronary heart disease, whereas Chinese lowest. Conversely, lowest high‐density lipoprotein cholesterol (HDL‐C) concentrations, followed by Chinese. We studied TaqIB −629C>A polymorphisms at CETP locus in 1300 364 Malay 282 Indian men, 1558 397 306 women, to determine whether these are responsible for ethnic difference HDL‐C concentration. frequency B2 allele was...
Summary A 74‐year‐old man presenting for aortic reconstructive surgery showed severe, previously undiagnosed obstructive sleep apnoea during overnight oximetry monitoring before operation. Postoperatively, in the first 4 hours following extubation, he suffered 238 episodes of respiratory obstruction. These events were associated with frequent arousals, large fluctuations systolic and diastolic blood pressure. Administration nasal continuous positive airways pressure abolished obstructions...
Prolonged ventilatory support has been used to treat 51 patients with respiratory failure secondary skeletal (22) or neuromuscular (29) disease. Symptomatic relief was achieved in five rapidly progressive neurological disease who died within 27 months. The remaining 46 patients, aged 11-69 years at presentation, have followed for more than two and a half years. All but 10 were treated negative pressure ventilation from the outset, intermittent positive being initially others continued home...
<b>Higenbottam, T., Allen, D., Loh, L., and Clark, T. J. H. (1977).</b><i>Thorax,</i><b>32,</b> 589-595. <b>Abdominal wall movement in normals patients with hemidiaphragmatic bilateral diaphragmatic palsy.</b> The abdomen ribcage volume contribution to the tidal have been determined using magnetometers three groups of subjects—normal males, palsy, palsy. In all main moving parts appear be anterior surfaces even presence group paralysis abdominal moved inward paradoxically on inspiration....