A5016131030- Algal biology and biofuel production
- Marine and coastal plant biology
- Photosynthetic Processes and Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Microbial Metabolic Engineering and Bioproduction
- Sepsis Diagnosis and Treatment
- Lipid metabolism and biosynthesis
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Bone Tissue Engineering Materials
- Cancer Mechanisms and Therapy
- Aquaculture Nutrition and Growth
- Higher Education and Teaching Methods
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Angiogenesis and VEGF in Cancer
- Coastal wetland ecosystem dynamics
- Congenital gastrointestinal and neural anomalies
- Microbial Community Ecology and Physiology
- HIV Research and Treatment
- MicroRNA in disease regulation
- HIV/AIDS drug development and treatment
- Peptidase Inhibition and Analysis
- Marine Biology and Ecology Research
Shanghai Ocean University
2016-2025
West China Hospital of Sichuan University
2022-2025
Shanghai Jiao Tong University
2009-2025
Sichuan University
2022-2025
Shanghai First People's Hospital
2009-2025
Jiujiang First People's Hospital
2023-2025
Songjiang District Central Hospital
2018-2025
Second Affiliated Hospital of Nanchang University
2025
Nanchang University
2024-2025
First Affiliated Hospital of Jiangxi Medical College
2024-2025
Metabolic adjustments are necessary for the initiation, proliferation, and spread of cancer cells. Although mitochondria have been shown to move cells from their microenvironment, metabolic consequences this phenomenon yet be fully elucidated. Here, we report that multiple myeloma use mitochondrial-based metabolism as well glycolysis when located within bone marrow microenvironment. The reliance on oxidative phosphorylation was caused by intercellular mitochondrial transfer neighboring...
The high mortality and financial burden associated with prostate cancer can be partly attributed to a lack of sensitive screening methods for detection staging the disease. Guided by in silico docking studies using crystal structure PSMA, we designed synthesized series PSMA-targeted (99m)Tc-chelate complexes imaging PSMA-expressing human cells (LNCaP cell line). Of six targeted radioimaging agents synthesized, three were found bind LNCaP low nanomolar affinity. Moreover, same shown localize...
Angiogenesis plays an important role in hepatocellular carcinoma (HCC), the inhibition of which is explored for cancer prevention and treatment. The dietary phytochemical sulforaphane (SFN) known its anti-cancer properties vitro vivo; but until now, no study has focused on SFN HCC tumor angiogenesis. In present study, cell models using a line, HepG2, human endothelial cells, HUVECs, as well ex vivo have been used to investigate anti-tumor anti-angiogenic effect SFN. results showed that...
Background and aim:As non-coding RNAs, circular RNAs (circRNAs) contribute to the progression of malignancies by regulating various biological processes.In prostate cancer, however, there is still a lack understanding regarding potential molecular pathways roles circRNAs.Methods: Loss-off function experiments were performed investigate circRNA in cancer.Western blot, qRT-PCR, IHC assay used examine expression level different genes or circRNAs.Further biology conducted uncover mechanism...
Structural defects and biological inertness significantly impair the integration of titanium alloy implants bone tissues. In spinal internal fixation, issue pedicle screw loosening or fracture caused by poor urgently needs solving. this study, we utilized 3D printing technology to custom fabricate a structurally optimized porous with aim enhancing regeneration at defect site, thereby fixation implant in vivo. Results showed that unit has superior mechanical properties actively promotes cell...
Infection by the mosquito-borne dengue virus causes fever and sometimes fatal hemorrhagic fever. The increasing number of infections per year suggests that is becoming more virulent its transmission expanding. Nevertheless, no effective treatment for infection currently exists. In a search antiviral agents against virus, we investigated potential targeting structural protein site rather than an enzymatic one. Using this approach, now report discovery small molecule ligand inhibits viral...
Flavivirus envelope proteins (E proteins) have been shown to play a pivotal role in virus assembly, morphogenesis, and infection of host cells. Inhibition flavivirus cell by means small molecule protein antagonist is an attractive strategy for the development antiviral agents. Virtual screening NCI chemical database using dengue structure revealed several hypothetical hit compounds. Bioassay results identified class thiazole compounds with potency cell-based assays. Modification these lead...
The isothiocyanate (ITC) sulforaphane (SFN) was shown at low levels (1–5 µM) to promote cell proliferation 120–143% of the controls in a number human lines, whilst high (10–40 it inhibited such proliferation. Similar dose responses were observed for migration, i.e. SFN 2.5 µM increased migration bladder cancer T24 cells 128% migration. This hormetic action also found an angiogenesis assay where promoted endothelial tube formation (118% control), whereas 10–20 caused significant inhibition....
Allyl isothiocyanate (AITC), a dietary phytochemical in some cruciferous vegetables, exhibits promising anticancer activities many cancer models. However, previous data showed AITC to have biphasic effect on cell viability, DNA damage and migration human hepatoma HepG2 cells. Moreover, 3D co-culture of HUVEC with pericytes, it inhibited tube formation at high doses but promoted this low doses, which confirmed its angiogenesis. siRNA knockdown Nrf2 glutathione inhibition abolished the...
Camptothecin is a chemotherapeutic drug widely used to treat various cancers. Ophiorrhiza pumila an ideal plant model for the study of camptothecin production, with advantages studying biosynthesis and regulation. The DNA-binding WRKY transcription factors have key regulatory role in secondary metabolite plants. However, little currently known about their involvement O. pumila. We identified 46 OpWRKY genes unevenly distributed on 11 chromosomes Phylogenetic multiple sequence alignment...
Abstract Hydroxyapatite (HA) bioceramics have been extensively employed as bone tissue scaffolds owing to their biodegradability and osteoinductivity. In our work, HA, a significant component of natural used the raw material produce porous employing three‐dimensional (3D)‐printing technology. Physical chemical properties, porosity, compression resistance were investigated in vitro. The scaffold was confirmed large number interconnected pore structures on surface inside HA showed good cell...
This study aims to overcome the drawbacks associated with hydroxyapatite (HAP) dense structures after sintering, which often result in undesirable features such as large grain size, reduced porosity, high crystallinity, and low specific surface area. These characteristics hinder osseointegration limit clinical applicability of material. To address these issues, a new method involving preparation hollow (hHAP) microspheres has been proposed. exhibit distinctive traits including weak...
// Bo Su 1, 2, 3, * , Jian 4, Ying Zeng Fang Liu 2 Hong Xia Yan-Hua Ma Zhi-Gang Zhou Shuo Zhang Bang-Min Yang You-Hua Wu 1 Xi Xiao-Hong Ai Hui Ling Hao Jiang Qi Center for Gastric Cancer Research of Hunan Province, First Affiliated Hospital, University South China, Hengyang, 421001 Hunan, China Key Laboratory Cellular and Molecular Pathology Provincial University, Institute, 3 Pharmacoproteomics Institute Pharmacy Pharmacology, 4 Department Pathology, Second These authors have contributed...
Abstract Background Lung adenocarcinoma (LUAD) accounts for approximately 40% of all lung cancer patients. There is an urgent need to understand the mechanisms progression in LUAD and identify useful biomarkers predict prognosis. Methods In this study, Oncomine database was used potential genes contributed progression. Bioinformatics analysis including pathway enrichment text mining explain roles identified LUAD. The Cancer Genome Atlas analyze association gene expression with survival...