A5040392788- Helicobacter pylori-related gastroenterology studies
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Galectins and Cancer Biology
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Microfluidic and Bio-sensing Technologies
- CAR-T cell therapy research
- Glycosylation and Glycoproteins Research
- Circular RNAs in diseases
- Monoclonal and Polyclonal Antibodies Research
- Digestive system and related health
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Genomics and Chromatin Dynamics
- RNA and protein synthesis mechanisms
- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Gastroesophageal reflux and treatments
The Affiliated Hospital to Changchun University of Chinese Medicine
2025
Jiangxi Academy of Agricultural Sciences
2025
First Hospital of China Medical University
2013-2024
China Medical University
2015-2024
Kyoto University
2023-2024
Gezhouba Central Hospital of Sinopharm
2024
China Three Gorges University
2024
Shaoxing People's Hospital
2024
Cytel (United States)
2023-2024
State Grid Hebei Electric Power Company
2024
Anti-CD20/CD3 T cell–dependent bispecific antibodies may be useful for the treatment of B cell malignancies.
Georgia A. Patikoglou, Joseph L. Kim, Liping Sun, Sang-Hwa Yang, Thomas Kodadek, and Stephen K. Burley Laboratories of Molecular Biophysics, Howard Hughes Medical Institute, The Rockefeller University, New York, York 10021 USA; Departments Internal Medicine Biochemistry, Ryburn Cardiology Center, University Texas Southwestern Dallas, 75235-8573 USA
Objectives: We aimed to assess a serological biopsy using five stomach-specific circulating biomarkers—pepsinogen I (PGI), PGII, PGI/II ratio, anti-Helicobacter pylori (H. pylori)antibody, and gastrin-17 (G-17)—for identifying high-risk individuals predicting risk of developing gastric cancer (GC). Methods: Among 12,112 participants with prospective follow-up from an ongoing population-based screening program both serology gastroscopy in China, we conducted multi-phase study involving...
Our previous reports suggested that dietary supplementation with lysine influenced intestinal absorption and metabolism of amino acids. In this study, we further investigated the effect restriction (30%) on feed intake also tested hypothesis gut microbiome contributed to potential mechanism restriction-mediated feeding behavior. Here, profiled microbial communities by sequencing 16S ribosomal ribonucleic acid (rRNA) genes from samples as well growth performance, serum hormones, transport in...
Abstract Mosunetuzumab, a T-cell dependent bispecific antibody that binds CD3 and CD20 to drive mediated B-cell killing, is currently being tested in non-Hodgkin lymphoma. However, potent immune stimulation with directed therapies poses the risk of cytokine release syndrome, potentially limiting dose utility. To understand mechanisms behind safety efficacy explore mitigation strategies, we developed novel mechanistic model antitumor responses bispecifics (mosunetuzumab blinatumomab),...
Abstract Background Microbial communities associated with roots play a crucial role in the growth and health of plants are constantly influenced by plant development alterations soil environment. Despite extensive rhizosphere microbiome research, studies examining multi-kingdom microbial variation across large-scale agricultural gradients remain limited. Results This study investigates soybean 13 diverse geographical locations China. Using high-throughput shotgun metagenomic sequencing on...
A brief, process-oriented overview of immunologically based cell separation technology is presented. In addition, the design and preliminary experimental data two unique flow-through immunomagnetic devices are The first on a dipole magnetic field, while second basis quadrupole field. can "fractionate" an inlet, magnetically labeled, stream into different outlet streams degree to which immunomagnetically labeled. separator splits in purity, recovery, potentially cells labeled controlled by...
Antihypertensive effect of long-term oral administration jellyfish (Rhopilema esculentum) collagen peptides (JCP) on renovascular hypertension rats (RVHs) was evaluated. The systolic blood pressure and diastolic the RVHs were significantly reduced with JCP (p < 0.05), compared model control group. However, arterial normal showed no significant changes during treatment high dose > 0.05). Furthermore, angiotensin II (Ang II) concentration plasma had significance but inhibited Ang in...
This study aimed to investigate the long-term effects of protein restriction from piglets finishing pigs for 16 weeks on meat quality, muscle amino acids, and acid transporters. Thirty-nine were randomly divided into three groups: a control (20-18-16% crude protein, CP) two restricted groups (17-15-13% CP 14-12-10% CP). The results showed that severe (14-12-10% inhibited feed intake body weight, while moderate had little effect growth performance in pigs. Meat quality (i.e., pH, color...
Background: Emerging evidence suggested that aberrant alternative splicing (AS) is pervasive event in development and progression of cancer. However, the information events involved colorectal carcinogenesis still elusive. Materials Methods: In this study, data 499 colon adenocarcinoma cases (COAD) 176 rectum (READ) with clinicopathological were obtained from The Cancer Genome Atlas (TCGA) to explore changes relation prognosis cancer (CRC). Gene interaction network construction, functional...
Methylation plays an important role in the etiology and pathogenesis of colorectal cancer (CRC). This study aimed to identify aberrantly methylated-differentially expressed genes (DEGs) pathways CRC by comprehensive bioinformatics analysis.Data gene expression microarrays (GSE68468, GSE44076) methylation (GSE29490, GSE17648) were downloaded from GEO database. Aberrantly methylated-DEGs obtained GEO2R. Functional enrichment analyses selected performed using DAVID Protein-protein interaction...
Hox proteins frequently select and regulate their specific target genes with the help of cofactors like Extradenticle (Exd) Homothorax (Hth). For Drosophila protein Sex combs reduced (Scr), Exd has been shown to position a normally unstructured portion Scr so that two basic amino acid side chains can insert into minor groove an Scr-specific DNA-binding site. Here we provide evidence another protein, Deformed (Dfd), uses very similar mechanism achieve specificity in vivo, thus generalizing...
Emerging evidence supports the critical roles of long noncoding RNA (lncRNA) in cervical cancer. However, pathological lncRNA POU3 F3 cancer tumorigenesis are still elusive. was validated to be up-regulated tissue specimens and cells comparing with normal controls. Moreover, ectopic overexpression closely correlated poor prognosis. In vitro, promoted proliferation, invasion cells. vivo, knockdown repressed tumor growth The transcriptional expression activated by transcription factor SP1....
Variant in pri-miRNA could affect miRNA expression and mature process or splicing efficiency, thus altering the hereditary susceptibility prognosis of cancer. We aimed to assess miRNA-let-7 single nucleotide polymorphisms (SNP) associated with risk gastric cancer (GC) as predicting biomarkers, furthermore, its possible mechanisms.A two-stage case-control study was designed screen four SNPs (pri-let-7a-2 rs629367 rs1143770, pri-let-7a-1 rs10739971, pri-let-7f-2 rs17276588) 107 GC patients,...
The growth and astaxanthin production of Chlorella zofingiensis were examined under both heterotrophic photoautotrophic conditions, it was found that, in comparison to the mode, mode led high algal densities but attenuated intracellular accumulation. Following heterotrophy–photoautotrophy transition, a considerable increase content observed, accompanied by upregulation key carotenogenic genes, including phytoene synthase (PSY), β-carotenoid hydroxylase (CHYb), ketolase 1 (BKT1), 2 (BKT2). In...
As the most critical alternative splicing regulator, heterogeneous nuclear ribonucleoproteins (hnRNPs) have been reported to be implicated in various aspects of cancer. However, comprehensive understanding hnRNPs cancer is still lacking. The molecular alterations and clinical relevance hnRNP genes were systematically analysed 33 types based on next-generation sequence data. expression, mutation, copy number variation, functional pathways, immune cell correlations prognostic value...
Heterotopic ossification (HO) is a non-physiological bone formation where soft tissue progenitor cells differentiate into chondrogenic cells. In fibrodysplasia ossificans progressiva (FOP), rare genetic disease characterized by progressive and systemic HO, the Activin A/mutated ACVR1/mTORC1 cascade induces HO in progenitors muscle tissues. The relevant biological processes aberrantly regulated activated mTORC1 remain unclear, however. RNA-sequencing analyses revealed enrichment of genes...