A5103030241- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Glioma Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Meningioma and schwannoma management
- TGF-β signaling in diseases
- Gut microbiota and health
- Hormonal Regulation and Hypertension
- Protein Degradation and Inhibitors
- Diet and metabolism studies
- Cancer, Hypoxia, and Metabolism
- Heat shock proteins research
- Viral-associated cancers and disorders
- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chromatin Remodeling and Cancer
- Histone Deacetylase Inhibitors Research
- Chronic Myeloid Leukemia Treatments
- Neuroblastoma Research and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Testicular diseases and treatments
- Neuroendocrine Tumor Research Advances
- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
Fudan University
2010-2024
State Key Laboratory of Medical Neurobiology
2024
Shanghai Center for Brain Science and Brain-Inspired Technology
2021-2024
Tongren Hospital
2024
Shanghai Jiao Tong University
2024
Huashan Hospital
2018-2024
Orthopaedic Hospital
2024
Shanghai Cancer Institute
2018-2022
Shanghai Clinical Research Center
2020-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2022
Dysbiosis of gut microbiota is associated not only with intestinal disorders but also numerous extraintestinal diseases. Growth hormone-secreting pituitary adenoma (GHPA) an insidious disease persistent hypersecretion GH and IGF-1, causing increased morbidity mortality.
Growth hormone pituitary adenoma (GHPA), a major subtype of (PA), can lead to progressive somatic disfigurement, multiple complications, and even increased mortality. The efficacy current treatments is limited; thus, novel pharmacological treatment urgently needed. As histone acetyltransferase (HAT) coactivator, p300 regulate the transcription several genes that are crucial for PA tumorigenesis progression. However, role its catalytic inhibitor in GHPA still unclear.We aimed identify...
Nonfunctioning pituitary adenoma (NFPA) and growth hormone (GHPA) are major subtypes of adenomas (PAs). The primary treatment is surgical resection. However, radical excision remains challenging, few effective medical therapies available. It urgent to find novel targets for the treatment. Bromodomain-containing protein 4 (BRD4) an epigenetic regulator that leads aberrant transcriptional activation oncogenes. Herein, we investigated pathological role BRD4 evaluated effectiveness inhibitors in...
Objective: Quality of Life (QoL) has been a multifactorial concerning issue in oncology. We aimed to inspect the pre-operative QoL among patients with craniopharyngioma and explore potential correlations between parameters clinical indices. Subjects methods: enrolled total 109 craniopharyngioma. utilized Short Form 36 (SF-36), Symptom Check List-90, Generalized Anxiety Disorder Questionnaire scale (GAD7), Patient Health Depression (PHQ9) Pittsburgh Sleep Index prospectively evaluated their QoL. [...]
Background: Surgical treatment of complex giant pituitary adenomas (GPAs) presents significant challenges. The efficacy and safety combining transsphenoidal transcranial approaches for these tumors remain controversial. In this largest cohort patients with GPAs, we compared the surgical outcomes between those undergoing a combined regimen non-combined regimen. We also examined differences in risks complications, costs, logistics two groups, which might offer valuable information appropriate...
Objective: To investigate the factors associated with recurrence/progression after endoscopic endonasal resection of suprasellar craniopharyngiomas. Special attention was paid to assess impact pituitary stalk preservation on tumor and endocrinological outcomes. Methods: We retrospectively recruited 73 patients craniopharyngiomas undergone approach (EEA) surgery from September 2014 May 2019 assessed their clinical characteristics, surgical outcomes, recurrence/progression. Stalk or sacrifice...
Purpose To investigate the role of heat-shock protein Hsp90 in adrenocorticotropic hormone (ACTH)-secreting cells, and to explore potential clinical application an inhibitor Hsp90, 17-N-allylamino-17-demethoxygeldanamycin(17-AAG) corticotropinomas [also known as “Cushing’s disease” (CD)]. Methods Culture mouse pituitary tumor [AtT-20/D16v-F2 (ATCC ® CRL-1795™)] cells human ACTH-secreting were employed. Hepatocellular carcinoma cell line (HLE) was used evaluate EGFR inhibition by 17-AAG. Cell...
Aim: The conflicting evidence as to whether a real association exists between cortisol levels and depression lends support adopting Mendelian randomization approach investigate have causal effect with depression. Methods: Single nucleotide polymorphisms (SNPs) associated serum morning plasma level salivary from CORNET consortium (12,597 participants) were proposed instrumental variables. primary outcome was depression, the secondary outcomes neuroticism cognitive performance. Summary-level...
The present study investigated the factors associated with recurrence during long-term follow-up in acromegaly and compared rate between patients remission 2010 vs 2000 consensus criteria. We retrospectively recruited 133 adult acromegalic who had undergone transsphenoidal surgery (TSS) from January 2013 to December 2014 assessed their clinical characteristics, surgical outcomes recurrence. Surgical was defined as normalised insulin-like growth factor 1 (IGF-1) nadir hormone (GH) an oral...
Abstract Background The pathogenesis of Cushing’s disease (CD) is still not adequately understood despite the identification somatic driver mutations in USP8, BRAF, and USP48. In this multiomics study, we combined RNA sequencing (RNA-seq) with Sanger to depict transcriptional dysregulation under different gene mutation backgrounds. Furthermore, evaluated potential achaete-scute complex homolog 1 (ASCL1), a pioneer transcription factor, as novel therapeutic target for treatment CD its...
Abstract Purpose Growth hormone-secreting pituitary adenoma (GHPA) is an insidious disease with persistent hypersecretion of growth hormone and insulin-like factor 1, causing increased morbidity mortality. Previous studies have investigated the transcription GHPA. However, gene regulatory landscape has not been fully characterized. The objective our study was to unravel changes in chromatin accessibility Methods Six patients diagnosed GHPA Department Neurosurgery at Huashan Hospital were...
Abstract Early-life is a critical period for neurodevelopment and establishment of gut microbiota, which are highly susceptible to antibiotic exposure. Here, we aimed investigate association between microbiota metabolites with neuroregeneration in early-life after To induce microbial dysbiosis offspring, broad-spectrum cocktail was administered mice dams. The prefrontal lobe, spinal cord tissues sample offspring were collected at different time or without crush injury. 16S rRNA sequencing...
<title>Abstract</title> <bold>Purpose:</bold> Growth hormone pituitary adenoma (GHPA) is a major subtype of (PA), with tumor enlargement and abnormal secretion growth (GH) often causing complications. Rac GTPase-activating protein 1 (RACGAP1), member the guanine triphosphatase-activating family, highly overexpressed in multiple tumors promotes growth. However, role RACGAP1 GHPA remains unelucidated. Besides, specific inhibitors targeting have not yet been developed. In this study, we aimed...