A5101695935- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Cancer-related gene regulation
- RNA modifications and cancer
- Ultrasound and Cavitation Phenomena
- Cancer-related molecular mechanisms research
- Water Treatment and Disinfection
- Cytokine Signaling Pathways and Interactions
- Bone Metabolism and Diseases
- Diet and metabolism studies
- Connective tissue disorders research
- Mesenchymal stem cell research
- Intensive Care Unit Cognitive Disorders
- Pharmacological Effects of Medicinal Plants
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Pelvic and Acetabular Injuries
- Biomarkers in Disease Mechanisms
- Bone health and treatments
- Plasma Applications and Diagnostics
- Fibroblast Growth Factor Research
- Bone Tissue Engineering Materials
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Myofascial pain diagnosis and treatment
Third Affiliated Hospital of Southern Medical University
2019-2024
Orthopaedic Hospital
2024
Southern Medical University
2018-2021
Nanfang Hospital
2021
Dalian Maritime University
2015
The aim of this study was to explore the regulatory mechanism circRNA_100876/ microRNA-136 (miR-136) axis in development and progression osteosarcoma cancer. Quantitative real-time polymerase chain reaction (RT-qPCR) used evaluate expression levels circRNA_100876 miR-136 cancer samples adjacent nontumor tissues. Then, cell proliferation, cycle, apoptosis, migration circRNA_100876-knocked down cells were analyzed by vitro vivo experiments, using counting kit-8 (CCK-8), flow cytometry,...
Background: Osteosarcoma (OS) is the most prevalent bone cancer among children and adolescents, with relatively high mortality rates. RNA N6-methyladenosine (m6A) common human mRNA modification diverse functions in a variety of biological processes. Previous studies indicated that methyltransferase-like 3 (METTL3), first methyltransferase to be identified, acted as an oncogene or tumor suppressor multiple cancers. However, its underlying mechanisms OS progression remain unclear; therefore,...
The C-X-C motif chemokine ligand 2 (CXCL2), a member of the CXC receptor family, is involved in various immune and inflammatory processes, but its effect(s) on bone formation have not yet been reported. We report here that CXCL2 enriched marrow show abundant expression osteoblasts osteoporotic mice. neutralization within by using antibody alleviated loss mice, indicating negative role formation. In line with this, overexpression attenuated proliferation, as well differentiation, vitro By...
Background: During osteoporosis, bone mesenchymal stem cells (BMSCs) lineage commitment shifts to adipocytes, causing fat accumulation and loss in the skeleton. Seeking drugs that could reverse adipocyte fate determination of BMSCs is critical for osteoporosis therapy. As a traditional Chinese medicine, Rhizoma Curculiginis (Xianmao) has been used treat diseases promote healing, while effective constituent it underlying mechanisms are unknown. Objectives: The aim this study unveil role...
Study Design. Anatomical study. Objective. This study aimed to elaborate on the anatomical characteristics of medial branch lumbar dorsal rami and discuss its possible clinical significance. Summary Background Data. Radiofrequency ablation targeting has been increasingly used in management facetogenic low back pain (FLBP). Nonetheless, attention is also being given complications such as atrophy soft tissues muscles. Therefore, a more detailed understanding innervation pattern facet joint may...
Abstract Cadaveric study; To describe the characteristics of nerve and its relationship with lumbar intervertebral disc psoas major muscle. Nerve injury is an understudied complication extreme lateral interbody fusion. A detailed description anatomy would be helpful for surgeons to minimize risk this complication. The plexus sympathetic 10 embalmed male cadavers were dissected, distribution, number, spatial orientation nerves on L1/2 L4/5 discs examined. Metal wires applied along paths...
Absence of effective therapeutic methods for avascular necrosis femoral head (ANFH) is still perplexing the world's medical community. Bone marrow mesenchymal stem cells (BMSCs) adoptive cell therapy combined with core decompression a promising modality, which highly dependent on cellular activities BMSCs. Hepatocyte growth factor (HGF) survival BMSCs, yet underlying mechanism not fully elucidated. In this study, effects multiplicity infections (MOIs) recombinant adenovirus carrying HGF gene...
Objective: The present study was conducted for exploring the influence of fibroblast growth factor 2 receptor (FGFR2) gene polymorphisms on osteoporosis occurrence risk in Chinese population.Methods: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) genotyping 145 patients and 123 controls. status Hardy-Weinberg equilibrium detected control group. Genotype allele frequency comparison between two groups performed by χ2 test, odds ratio (OR) with 95% confidence...
Background: The purpose of our research was to explore potential value lncRNA-BC050642 in osteosarcoma origination and prognosis. Methods: In this study, the tissue specimens were collected from 97 patients age-matched healthy controls. Besides, human cell lines U2OS normal osteoblastic line hFOB1.19 selected for experiments vitro. levels measured through quantitative real-time polymerase chain reaction (qRT-PCR). Relative expression gene c-myc determined via ELISA analysis. x2 test...
Reactive oxygen species (ROS, e.g., ·OH, ·O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> <sup xmlns:xlink="http://www.w3.org/1999/xlink">-</sup> , xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> O H xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> ) produced in advanced oxidation technologies (AOT) are well accepted to be one of the most lethal factors that responsible for bacteria inactivation during drinking water treatment....
Background and objectives Rami communicantes (RC) infiltration radiofrequency lesions are new techniques for the treatment of discogenic low back pain (DLBP). Their efficacy is controversial, classification RC remains unclear. We aimed to explore differences between reclassify according their anatomical characteristics. Methods Sixteen sides lumbar spine from eight adult male embalmed cadavers were dissected. The presence was noted. morphology, origin, distribution, course, quantity spatial...
Abstract Early-life is a critical period for neurodevelopment and establishment of gut microbiota, which are highly susceptible to antibiotic exposure. Here, we aimed investigate association between microbiota metabolites with neuroregeneration in early-life after To induce microbial dysbiosis offspring, broad-spectrum cocktail was administered mice dams. The prefrontal lobe, spinal cord tissues sample offspring were collected at different time or without crush injury. 16S rRNA sequencing...