A5100756978- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Parkinson's Disease Mechanisms and Treatments
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Meningioma and schwannoma management
- Botulinum Toxin and Related Neurological Disorders
- TGF-β signaling in diseases
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Myasthenia Gravis and Thymoma
- Single-cell and spatial transcriptomics
- Neurological disorders and treatments
- MicroRNA in disease regulation
- Neuroendocrine Tumor Research Advances
- Lung Cancer Treatments and Mutations
- Nerve injury and regeneration
- Gout, Hyperuricemia, Uric Acid
- Adrenal Hormones and Disorders
- Head and Neck Surgical Oncology
- Circular RNAs in diseases
- PARP inhibition in cancer therapy
Union Hospital
2020-2025
Sichuan University
2021-2025
Huazhong University of Science and Technology
2020-2025
Second Affiliated Hospital of Soochow University
2014-2024
Soochow University
2014-2024
Huashan Hospital
2015-2024
Fudan University
2015-2024
Shanghai Clinical Research Center
2020-2024
Shanghai Center for Brain Science and Brain-Inspired Technology
2021-2024
Shanghai Cancer Institute
2016-2024
Cushing's disease, also known as adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas (PAs) that cause excess cortisol production, accounts for up to 85% of corticotrophin-dependent syndrome cases. However, the genetic alterations in this disease are unclear. Here, we performed whole-exome sequencing DNA derived from 12 ACTH-secreting PAs and matched blood samples, which revealed three types somatic mutations a candidate gene, USP8 (encoding ubiquitin-specific protease 8),...
Olaparib, the world's first poly ADP-ribose polymerase (PARP) inhibitor (PARPi), has been approved for treatment of ovarian cancer, breast pancreatic cancer and prostate by FDA. The current study was to assess olaparib-related adverse events (AEs) real-world through data mining US Food Drug Administration Adverse Event Reporting System (FAERS).Disproportionality analyses, including reporting odds ratio (ROR), proportional (PRR), Bayesian confidence propagation neural network (BCPNN)...
Recombinant zoster vaccine (RZV), received its first marketing authorization in October 2017 to prevent herpes and complications older adults. The purpose of this study was provide comprehensively worldwide post-marketing safety information about RZV using data from the Vaccine Adverse Event Reporting System (VAERS). We searched for analyzed adverse event (AE) reports submitted U.S. VAERS between 20, April 26, 2024. Descriptive analyses included sex, age, time-to-onset, seriousness, most...
Cushing's disease results from corticotroph adenomas of the pituitary that hypersecrete adrenocorticotropin (ACTH), leading to excess glucocorticoid and hypercortisolism. Mutations deubiquitinase gene USP8 occur in 35-62% adenomas. However, major driver mutations wild-type tumors remain elusive. Here, we report recurrent USP48 (predominantly encoding p.M415I or p.M415V; 21/91 subjects) BRAF (encoding p.V600E; 15/91 with USP8. Similar mutants, both mutants enhance promoter activity...
Purpose: Secukinumab was approved for the treatment of psoriasis, psoriatic arthritis, and ankylosing spondylitis. However, long-term safety secukinumab in large sample population unknown. The current study to evaluate secukinumab-assocaited adverse events (AEs) through data mining US Food Drug Administration Adverse Event Reporting System (FAERS). Methods: Reports FAERS from first quarter 2015 (FDA approval secukinumab) third 2021 were collected analyzed. Disproportionality analyses,...
Abstract Pituitary neuroendocrine tumor (PitNET) is one of the most common intracranial tumors. Due to its extensive heterogeneity and lack high-quality tissues for biomarker discovery, causative molecular mechanisms are far from being fully defined. Therefore, more studies needed improve current clinicopathological classification system, advanced treatment strategies such as targeted therapy immunotherapy yet be explored. Here, we performed largest integrative genomics, transcriptomics,...
Pituitary neuroendocrine tumor (PitNET) is one of the most common intracranial tumors with variable recurrence rate. Currently, prediction unsatisfying and can be improved by understanding cellular origins differentiation status. Here, to comprehensively reveal origin PitNET, we perform comparative analysis single-cell RNA sequencing data from 3 anterior pituitary glands 21 PitNETs. We identify distinct genes representing major subtypes well poorly differentiated PitNETs in each lineage. To...
Background Risankizumab, a humanized IgG1 monoclonal antibody that selectively inhibits IL-23, is currently approved for the treatment of moderate-to-severe plaque psoriasis and Crohn’s disease. The real-world safety study risankizumab in large- sample population lacking. aim this was to evaluate risankizumab-associated adverse events (AEs) characterize clinical priority through data mining Food Drug Administration (FDA) Adverse Event Reporting System (FAERS). Methods Disproportionality...
Somatic structural variations (Somatic SVs) are critical genomic alterations with significant implications in cancer genomics. Although long-read sequencing (LRS) theoretically provides optimal resolution for detecting these variants due to its ability span large segments, current LRS - based methods, which derived from short read somatic SV detection algorithms, mainly rely on split information. The high error rate of long and the errors introduced by seed-and-chaining strategy mainstream...
Higher plasma urate level is reported to be associated with a reduced risk and slower progression of Parkinson's disease (PD). In this study, we explored the effects on dopaminergic neurons in nigrostriatal pathway 6-hydroxydopamine (6-OHDA) unilaterally lesioned rats. Uric acid (UA), when given twice daily at 200 mg/kg intraperitoneally for 10 consecutive days, elevated (the anionic form UA) striatum by 55% 36.8%, respectively, as compared vehicle group. This regimen UA was found ameliorate...
Skull base chordoma (SBC) is a bone cancer with high recurrence rate, radioresistance and poorly understood mechanism. Here, we profiled the transcriptomes of 90,691 single cells, revealed SBC cellular hierarchies, explored novel treatment targets. We identified cluster stem-like cells that tended to be distributed in inferior part tumor. Combining radiated UM-Chor1 RNA-seq data vitro validation, further found this cell marked by cathepsin L (CTSL), gene involved packaging telomere ends, may...
Abstract Objective To review experience regarding the treatment of prolactinomas by endoscopic endonasal surgery focusing on association between presurgical dopamine agonist (DA) and perioperative outcomes, surgical morbidities, endocrine pathological characteristics. Methods A single-center series 290 cases was analyzed retrospectively clinical data were collected. Intratumoral collagen content assessed Masson trichrome staining. Results Tenacious tumor consistency (27.8% vs 9.8%, P...
Background Mounting evidence shows that urate may become a biomarker of Parkinson's disease (PD) diagnosis and prognosis neuroprotectant candidate for PD therapy. However, the cellular molecular mechanisms underlying its neuroprotective actions remain poorly understood. Results In this study, we showed pretreatment protected dopaminergic cell line (SH-SY5Y MES23.5) against 6-hydroxydopamine (6-OHDA)- hydrogen peroxide- induced damage. Urate was found to be accumulated into SH-SY5Y cells...
To compare neurocognitive functioning of Type 1 diabetic mellitus (T1DM) and healthy adults, explore risk factors cognitive dysfunction T1DM patients, especially the association between impairment peripheral neuropathy (DPN). Seventy (age: 32.17 ± 9.57 yr., duration: 8.99 7.02 yr) patients 48 volunteers were included. All subjects received evaluation MMSE MoCA scales. Cognitive function was evaluated in different domains. Risk affecting further explored. Three with educational level ≤ 6-year...
Abstract Objective To investigate the diagnostic value of serum neurofilament light chain (NFL) for discriminating Parkinson disease (PD) from Essential tremor (ET) and healthy controls, to evaluate its correlation with some clinical features PD patients. Methods This cross-sectional study measured NFL levels electrochemiluminescence immunoassay in 146 patients, 82 ET patients 60 age-matched controls. We used multivariate regression analyses examine whether contributes biomarkers. Disease...
Circular RNA (circRNA) participates in a variety of pathophysiological processes, including the development gastric cancer (GC). However, role circ_0006089 GC progression and its underlying molecular mechanism need to be further revealed. Quantitative real-time PCR was utilized for detecting circ_0006089, microRNA (miR)-361-3p transforming growth factor-β1 (TGFB1) expression. The interaction between miR-361-3p or TGFB1 confirmed using dual-luciferase reporter assay an immunoprecipitation...
We aim to study surgical technique and analyze the related factors affecting tumor total removal postoperative endocrinological remission for endoscopic endonasal pituitary adenomas surgery.We retrospectively analyzed 178 surgery from March 2011 May 2014. Endonasal approach included routine transnasal-sphenoidal approach, transnasal- maxillary sinus in four cases transnasal-clivus one case.According imaging data endocrine examination results, was achieved 129 patients (72.5%), 38 with...
Colon cancer is the second most lethal malignancy worldwide. A better understanding of colon at molecular level may increase overall survival rates. Previous studies have indicated that prolyl 4‑hydroxylase, β polypeptide (P4HB) associated with tumorigenesis in cancer; however, its role and mechanisms remain unclear. In present study, cellular responses to P4HB human cell lines were investigated by proliferation apoptosis assays, western blotting, immunohistochemistry. The results showed...