A5100723956- Diabetes and associated disorders
- Pancreatic function and diabetes
- Advanced biosensing and bioanalysis techniques
- Electrochemical sensors and biosensors
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Lipid metabolism and disorders
- Gestational Diabetes Research and Management
- SARS-CoV-2 and COVID-19 Research
- Diabetes Management and Research
- Biosensors and Analytical Detection
- Immune Cell Function and Interaction
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pregnancy and preeclampsia studies
- T-cell and B-cell Immunology
- Metabolism, Diabetes, and Cancer
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Genetic Associations and Epidemiology
- Cancer Immunotherapy and Biomarkers
- Bone health and osteoporosis research
- Advanced Nanomaterials in Catalysis
- Cancer-related molecular mechanisms research
- Long-Term Effects of COVID-19
Second Affiliated Hospital of Soochow University
2007-2024
Gilead Sciences (United States)
2019-2024
Soochow University
2015-2024
Wenzhou Medical University
2024
Nanjing Medical University
2009-2024
Hubei University of Medicine
2023-2024
Taihe Hospital
2023-2024
Jiangsu Province Hospital
2020-2024
Zunyi Medical University
2024
Xi’an Children’s Hospital
2024
Coronavirus disease 2019 (COVID-19) is currently a global pandemic, but human immune responses to the virus remain poorly understood. We used high-dimensional cytometry analyze 125 COVID-19 patients and compare them with recovered healthy individuals. Integrated analysis of ~200 ~50 clinical features revealed activation T cell B subsets in proportion patients. A subgroup had characteristic acute viral infection plasmablast reaching >30% circulating cells. However, another lymphocyte...
The genomic sequences of severe acute respiratory syndrome coronaviruses from human and palm civet the 2003/2004 outbreak in city Guangzhou, China, were nearly identical. Phylogenetic analysis suggested an independent viral invasion animal to this new episode. Combining all existing data but excluding singletons, we identified 202 single-nucleotide variations. Among them, 17 are polymorphic civets only. ratio nonsynonymous/synonymous nucleotide substitution collected 1 yr apart different...
Abstract COVID-19 has become a global pandemic. Immune dysregulation been implicated, but immune responses remain poorly understood. We analyzed 71 patients compared to recovered and healthy subjects using high dimensional cytometry. Integrated analysis of ∼200 >30 clinical features revealed activation T cell B subsets, only in some patients. A subgroup had characteristic acute viral infection plasmablast could reach >30% circulating cells. However, another lymphocyte comparable...
Significance Statement Findings in animal models of diabetic kidney disease identified selonsertib, a selective inhibitor apoptosis signal–regulating kinase 1 (ASK1), as potential therapeutic agent. In randomized, dose-ranging, placebo-controlled phase 2 trial evaluating selonsertib’s safety and efficacy patients with moderate-to-advanced disease, the authors found that selonsertib appeared safe, no dose-dependent adverse effects over 48 weeks, including for 18-mg daily dose thought to...
OBJECTIVE Type 1 diabetes (T1D) is a highly heritable disease with much lower incidence but more adult-onset cases in the Chinese population. Although genome-wide association studies (GWAS) have identified >60 T1D loci Caucasians, less known Asians. RESEARCH DESIGN AND METHODS We performed first two-stage GWAS of using 2,596 autoantibody-positive case subjects and 5,082 control Han population evaluated associations between risk age fasting C-peptide levels at diagnosis. RESULTS...
Genome-wide association studies (GWAS) have revealed 19 common genetic variants that are associated with breast cancer risk. Testing of the index signals found through GWAS and fine-mapping each locus in diverse populations will be necessary for characterizing role these risk regions contributing to inherited susceptibility. In this large study African-American women (3016 cases 2745 controls), we tested known identified by replicated associations (P < 0.05) only 4 variants. Through...
Abstract Electrochemiluminescence (electrogenerated chemiluminescence, ECL), which involves light emission from excited states of electrochemically generated species at the electrode surface, is widely applied for chemical analysis. Integrating advantages outstanding selectivity biological recognition and high sensitivity ECL signaling, biosensors are powerful ultrasensitive bio‐checkups quantification, in luminol adopted as an important luminophore. Nanomaterials have been introduced into...
To compare neurocognitive functioning of Type 1 diabetic mellitus (T1DM) and healthy adults, explore risk factors cognitive dysfunction T1DM patients, especially the association between impairment peripheral neuropathy (DPN). Seventy (age: 32.17 ± 9.57 yr., duration: 8.99 7.02 yr) patients 48 volunteers were included. All subjects received evaluation MMSE MoCA scales. Cognitive function was evaluated in different domains. Risk affecting further explored. Three with educational level ≤ 6-year...
Selonsertib is an apoptosis signal-regulating kinase 1 inhibitor that reduces inflammation, fibrosis, and apoptosis. The MOSAIC study evaluated whether selonsertib attenuated kidney function decline in patients with diabetic disease.
Hypoxia-inducible factor 1 (HIF-1), a master regulator of oxygen homeostasis, is heterodimer consisting HIF-1α and HIF-1β subunits, implicated in calcification cartilage vasculature. The goal this study was to determine the relationship between serum with coronary artery (CAC) patients type 2 diabetes.The subjects were 405 (262 males, 143 females, age 51.3 ± 6.4 years) asymptomatic diabetes mellitus. Serum interleukin-6 (IL-6) levels measured by ELISA. CAC scores assessed 320-slice CT...
Objective Teriparatide could induce osteoblast differentiation of mesenchymal stem cells while inhibiting adipocyte differentiation. However, there are significant differences between ex vivo and in models. We aimed to evaluate the impact teriparatide on marrow abdominal fat accumulation postmenopausal osteopenic women.
Physical activity in a nonpregnant state or before pregnancy reduces the risk of type 2 diabetes and is also associated with reduced gestational mellitus (GDM). However, it uncertain whether physical during GDM.Using an established universal screening system Tianjin, China, we prospectively recruited 11 450 pregnant women within 12th week from 2010 to 2012. These underwent 50-g 1-h glucose challenge test (GCT) at 24-28 weeks gestation 75-g 2-h oral tolerance if GCT ≥7.8mmol/L. GDM was...
Abstract Background We aimed to estimate the performance of amino acids levels in predicting risk subsequent gestational diabetes mellitus (GDM). Methods A total 431 women at 12 16 weeks gestation Department Obstetrics and Gynecology Second Affiliated Hospital Soochow University were recruited. High‐performance liquid chromatography electrospray tandem mass spectrometry was used measure maternal blood gestation. At 24 28 gestation, all participants administered 75‐g oral glucose tolerance...
To investigate the prevalence and associated risk factors of microalbuminuria, to explore relationship between albuminuria cardiovascular disease (CVD). A nationally representative sample 38,203 Chinese participants was categorized by different levels urinary albumin-to-creatinine ratio (ACR; 0 -10 mg/g, 10 -20 20 -30 30 -300 mg/g). The compared using a single ACR cut-off point sex-specific points. Factors with presence albuminuria, CVD were analyzed logistic regression. Prevalence as...
Aims . The programmed death- (PD-) 1/PD-1 ligand (PD-L) pathway plays an important role in regulating T cell activation and maintaining peripheral tolerance. Accumulated studies showed that PD-1/PD-L1 was involved the development of type 1 diabetes (T1DM). Since genetic background differs greatly among different population, we aim to investigate association polymorphisms PD-1 PD-L1 with T1DM susceptibility Chinese population. Methods In total, 166 patients 100 healthy controls were enrolled...