A5112563262- Gastric Cancer Management and Outcomes
- Diet and metabolism studies
- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Meat and Animal Product Quality
- Aquaculture Nutrition and Growth
- Respiratory Support and Mechanisms
- Gastrointestinal motility and disorders
- Ion Channels and Receptors
- Diet, Metabolism, and Disease
- Metal-Organic Frameworks: Synthesis and Applications
- Epigenetics and DNA Methylation
- Gastrointestinal Tumor Research and Treatment
- Pain Mechanisms and Treatments
- Phytochemicals and Antioxidant Activities
- Pharmacological Effects and Toxicity Studies
- Ion channel regulation and function
- Sulfur Compounds in Biology
- Probiotics and Fermented Foods
- Cardiac Ischemia and Reperfusion
- Neuroscience and Neuropharmacology Research
- Urban Heat Island Mitigation
- Monoclonal and Polyclonal Antibodies Research
- Biochemical effects in animals
- Connective Tissue Growth Factor Research
Central South University of Forestry and Technology
2024-2025
Central South University
2024-2025
Harbin Medical University
2023-2025
Third Affiliated Hospital of Harbin Medical University
2023-2025
Southern Medical University
2019-2024
Huazhong Agricultural University
2020-2024
Shanxi Agricultural University
2024
Affiliated Hospital of Qingdao University
2024
Jilin University
2023-2024
Qingdao University
2024
ABSTRACT The gut microbiota contributes to skeletal muscle energy metabolism and is an indirect factor affecting meat quality. However, the role of specific microbes in fiber size chickens remains largely unknown. In this study, we first performed cecal transplantation from Chinese indigenous Jingyuan (JY) Arbor Acres (AA), determine effects on metabolism. Then, used metagenomics, gas chromatography, metabolomics analysis identify functional microbes. Finally, validated these regulating via...
Abstract Lysosomes are important cellular structures for human health as centers recycling, signaling, metabolism and stress adaptation. However, the potential role of lysosomes in stress‐related emotions has long been overlooked. Here, it is found that lysosomal morphology astrocytes altered medial prefrontal cortex (mPFC) susceptible mice after chronic social defeat stress. A screen lysosome‐related genes revealed expression mucolipin 1 gene ( Mcoln1 ; protein: TRP channel 1) decreased...
Costunolide not only improved gastrointestinal dysfunction but also ameliorated depressive-like behaviors in mice with stress-induced irritable bowel syndrome.
Background Stress hyperglycemia has served as a reliable biomarker to predict poor outcomes after ischemic stroke. However, recent studies have reported some contrary conclusions. Different stroke subtypes may respond inconsistently stress hyperglycemia. The progression of intracranial atherosclerotic stenosis (ICAS) is tightly related Thus, this study aims determine the relationship between and recurrent in patients with or without stenosis. Methods This multicenter retrospective...
Abstract Background The question as to whether or not diabetes mellitus increases the risk of idiopathic pulmonary fibrosis (IPF) remains controversial. This study aimed investigate causal association between type 1 (T1D), 2 (T2D), and IPF using Mendelian randomization (MR) analysis. Methods We used two-sample univariate multivariate MR (MVMR) analyses relationship T1D T2D IPF. obtained genome-wide (GWAS) data for from European Bioinformatics Institute, comprising 29,652 samples 101,101...
K2P potassium channels stabilize the resting membrane potential in nearly all cells and have been implicated several neuronal, cardiovascular, immune diseases. DCPIB, a known specific potent inhibitor of volume-regulated anion (VRAC), has reported to activate TREK1 TREK2 astrocytes vitro recently. In present study, we demonstrated DCPIB also voltage dependently activated TRAAK besides TREK1/TREK2, showing TREK subfamily members. contrast, compound potently inhibited other with no dependence,...
Valproate (valproic acid, VPA), a drug for the treatment of epilepsy and bipolar disorder, causes liver steatosis with enhanced oxidative stress. Accumulating evidences exhibite that gut microbiota plays an important role in progression nonalcoholic fatty disease (NAFLD). However, whether contributes to VPA-caused hepatic needs be elucidated. A mixture five probiotics was selected investigate their effects on stress mice orally administered VPA 30 days. Probiotics significantly attenuated...
Abstract BACKGROUND Conventional cryoprotectant mixtures (sucrose and sorbitol) impart excessive sweetness calories to surimi. Therefore, there is a need explore alternative cryoprotectants with low low‐calorie content. The cryoprotective effects possible mechanisms of soybean oligosaccharides (SBOS) on the frozen stability grass carp ( Ctenopharyngodon idellus ) surimi were investigated during 120 days storage in comparison commercial (4% sucrose 4% sorbitol, w/w). RESULTS SBOS at 6–8%...
The cryoprotective effects of mannan oligosaccharides (MOS) and curdlan (CU) on the quality grass carp surimi after freeze-thaw cycles (FTCs) were assessed using response surface methodology (RSM). optimal contents MOS (6.79%, w/w) CU (0.45%, produced minimum thawing losses highest gel strength five times FTCs. MOS, CU, their mixture demonstrated surimi. Compared to or alone, MOS-CU displayed synergistic effects, as evidenced by better prevention surimi, superior retardation aggregation...
FOLFOX combined with cetuximab is a recommended first-line treatment regimen for RAS/BRAF wild-type metastatic colorectal cancer (mCRC). CAPEOX differs from the by using oral capecitabine instead of continuous infusion fluorouracil, offering greater convenience and cost-effectiveness higher patient acceptance. However, comparative efficacy these two regimens remains debatable, necessitating further evidence to explore any differences in their efficacy. This study collected medical records...
Metastatic colorectal cancer (mCRC) is associated with poor prognosis and limited options for later-line treatment. Regorafenib TAS-102 have shown significant benefit are recommended as treatment mCRC. This study aimed to investigate the progression-free survival (PFS) overall (OS) of patients mCRC treated sequentially after regorafenib progression. population-based cohort retrospectively collected data 30 at Harbin Medical University Cancer Hospital Affiliated Shanxi from January 1, 2020,...
High glucose affects primary afferent neurons in dorsal root ganglia by inhibiting neurite elongation, causing oxidative stress, and inducing neuronal apoptosis mitochondrial dysfunction, which finally result damage. Proanthocyanidin, a potent antioxidant, has been shown to have neuroprotective effects. Proanthocyanidin B2 is common dimer of oligomeric proanthocyanidins. To date, no studies reported the effects proanthocyanidin against high-glucose-related neurotoxicity ganglion neurons. In...
This work aimed to characterise water‐in‐oil‐in‐water (W/O/W) microcapsules loading Lactiplantibacillus plantarum L 3 in a simulated fermentation and storage process for yoghurt, providing support their potential application complex fermented milk systems. The encapsulating efficiency of microencapsulated L. with modified pectin was 96.79%, the aerobic plate count 7.83 log cfu/g after gastrointestinal treatment. delayed post‐acidification MRS medium. cell‐free supernatant produced during...
We aimed to investigate the association between lactate/albumin ratio (LAR), and in-hospital mortality in critically ill patients with acute respiratory failure. This retrospective cohort study was conducted based on medical information mart for intensive care-IV database, which included adult failure whose primary endpoint death. The analyses curve fitting, a logistic multivariate regression model, subgroup analysis. In this study, 6028 care unit were analyzed. Of these, 1843 (30.57%) died....
Type 2 diabetes is an independent risk factor for non-alcoholic steatohepatitis (NASH) progression and its mediators have not been resolved. In this study, a pathogenic role of cellular communication network (CCN2) protein in NASH pathology, was investigated established preclinical model. Male wild type C57BL/6 mice received either Chow or high fat diet (HFD) 26 weeks, with some each group randomly selected to receive low dose streptozotocin (STZ: 3 i.p. injections, 65 mg/kg) at 15 weeks...
A diet-induced non-alcoholic fatty liver disease (NAFLD) model causing obesity in rodents was used to examine whether sitagliptin and gliclazide therapies have similar protective effects on pathological change.Male mice were fed a high-fat diet (HFD) or standard chow (Chow) ad libitum for 25 weeks randomly allocated oral treatment the final 10 weeks. Fasting blood glucose circulating insulin measured. Inflammatory fibrotic markers assessed by qPCR. The second messenger ERK autophagy examined...
Background: The mechanism of action envafolimab (also known as KN035), a programmed death ligand 1 (PD-L1) inhibitor, in gastric adenocarcinoma patients with low PD-L1 expression is not well understood. AIMS: This study aimed to observe the efficacy and explore underlying mechanisms. Objective: objective this was cancer expression. Method: Cytotoxicity proliferation were evaluated by CCK8 assay. Transwell assays used detect migration invasion ability cells. effect on apoptosis cells detected...