A5090056802- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Chronic Lymphocytic Leukemia Research
- Meningioma and schwannoma management
- Colorectal Cancer Treatments and Studies
- Neurofibromatosis and Schwannoma Cases
- Lymphoma Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced Biosensing Techniques and Applications
- Acute Myeloid Leukemia Research
- Multiple Myeloma Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Genomic variations and chromosomal abnormalities
- Pituitary Gland Disorders and Treatments
- Gastric Cancer Management and Outcomes
- Glioma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Gene expression and cancer classification
- Colorectal Cancer Surgical Treatments
- Advanced biosensing and bioanalysis techniques
- Lung Cancer Diagnosis and Treatment
- Advanced Proteomics Techniques and Applications
- Acute Lymphoblastic Leukemia research
- Prenatal Screening and Diagnostics
Instituto de Investigación Biomédica de Salamanca
2016-2025
Universidad de Salamanca
2016-2025
Centro de Investigación Biomédica en Red de Cáncer
2017-2025
Complejo Hospitalario de Salamanca
2012-2024
Centro de Investigación del Cáncer
2012-2021
Instituto de Biologia Molecular e Celular
2008-2010
Consejo Superior de Investigaciones Científicas
2008
Instituto de Estudios de Ciencias de la Salud de Castilla y León
2007
Abstract A heterogeneous spectrum of immunophenotypic abnormalities have been reported in myelodysplastic syndromes (MDS). However, most studies are restricted to the analysis CD34 + cells and/or other major subsets − cells, frequently not exploring diagnostic and prognostic impact immunophenotyping. Methods: We propose for first time an score (IS) based on altered distribution features maturing/mature compartments bone marrow (BM) hematopoietic 56 patients with MDS that could contribute a...
Metastatic dissemination is the most frequent cause of death sporadic colorectal cancer (sCRC) patients. Genomic abnormalities which are potentially characteristic such advanced stages disease complex and so far, they have been poorly described only partially understood. We evaluated molecular heterogeneity sCRC tumors based on simultaneous assessment overall GEP both coding mRNA non-coding RNA genes in primary tumor samples from 23 consecutive patients their paired liver metastases. Liver...
Tumor recurrence is the major clinical complication in meningiomas, and its prediction histologically benign/grade I tumors remains a challenge. In this study, we analyzed prognostic value of specific chromosomal abnormalities genetic heterogeneity tumor, together with other clinicobiological disease features, for predicting early relapses meningiomas. A total 149 consecutive meningiomas patients who underwent complete tumor resection were prospectively analyzed. Using interphase...
Meningiomas are usually considered benign tumors. However, relapses occur in 10% to 20% of all patients, including both histopathologically aggressive and This study explored the value numerical abnormalities for 10 different chromosomes meningiomas predicting relapse-free survival (RFS).This prospectively analyzed frequency 1, 9, 10, 11, 14, 15, 17, 22, X, Y 70 meningioma patients by fluorescence situ hybridization their relationship with disease characteristics at diagnosis patients'...
Abstract B‐cell chronic lymphocytic leukemia (B‐CLL) is a well‐defined clinical entity with heterogeneous molecular and cytogenetic features. Here, we analyze the impact of trisomy 12, del(13q), del(17p), del(11q) as determined by interphase fluorescence in situ hybridization analysis purified neoplastic B‐CLL cells on their immunophenotype, DNA ploidy status proliferative rate. Overall, 111 180 (62%) cases studied displayed one (50%) or more (12%) genetic abnormalities, del(13q) (35%) being...
Primary lymphomas of the uterine cervix are a rare disease. They often misdiagnosed because their rarity and they can be easily confused with squamous cell carcinoma cervix, as usually presented exophytic mass vaginal bleeding most common symptoms. Nevertheless, considering that both prognosis treatment completely different between them, differential diagnosis should taken into account.A case 51-year-old woman primary diffuse large B-cell lymphoma is presented.Diagnosis this tumor was...
It has long been recognized that spinal meningiomas show particular clinical and histological features. Here, we compare the clinico-biological characteristics as well genetic abnormalities patterns of gene expression intracranial meningiomas. Fourteen 141 meningioma patients were analyzed at diagnosis. In all tumors, interphase fluorescence in situ hybridization (iFISH) studies performed for detection quantitative 11 different chromosomes. Additionally, microarray analyses on a subgroup 18...
While the utility of circulating cell-free DNA (cfDNA) in cancer screening and early detection have recently been investigated by testing genetic epigenetic alterations, here, an original approach examining cfDNA quantitative structural features is developed. First, potential parameters independently demonstrated cell culture, murine, human plasma models. Subsequently, these variables are evaluated a large retrospective cohort 289 healthy individuals 983 patients with various types; after...
In the last few years, nivolumab has become standard of care for advanced-stage lung cancer patients. Unfortunately, up to 60% patients do not respond this treatment. our study, we identified variations in gene expression related primary resistance immunotherapy. Bronchoscopy biopsies were obtained from advanced non-small cell (NSCLC) previously characterized as responders or non-responders after Ten tumor (from three and seven non-responders) analyzed by differential 760 genes using...
Virulence (≡ severity of disease) and physiological specialization nine isolates Fusarium oxysporum f. sp. phaseoli recovered in El Barco de Avila (Castilla y León, west‐central Spain) two from Chryssoupolis (Greece) were determined. The susceptibility/resistance response showed by a differential set common bean cultivars ( Phaseolus vulgaris ) selected at the Centro Internacional Agricultura Tropical (CIAT) delineated into new races: races 6 7. results pathogenicity tests did not show any...
Much has been learned about the chromosomal abnormalities of colorectal carcinomas but cytogenetic relationship between neoplastic clones present in primary versus metastatic tumour samples remains unclear. We analyse frequency for 47 chromosome regions using interphase fluorescence situ hybridization technique a group 48 tumours, including 24 tumours and paired liver metastases. All showed complex karyotypes with numerical/structural seven or more different chromosomes/chromosome both their...
Cytogenetic studies in clonal plasma cell disorders have mainly been done whole bone marrow or CD138+ microbead-enriched cells and suggest that recurrent immunoglobulin heavy chain translocations - e.g. t(4;14) -are primary oncogenetic events. The aim of this study was to determine cytogenetic patterns highly purified aberrant (median purity ≥98%) different disorders. We analyzed from 208 patients with multiple myeloma (n=148) monoclonal gammopathy undetermined significance (n=60) for the...
Background and Aim: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types cancer; patients die during first 6 months after diagnosis. With a 5% 5-year survival rate, fourth leading cause cancer death in developed countries. In this regard, several clinical, histopathologic biological characteristics disease favoring long-term pancreaticoduodenectomy have been reported to be significant prognostic factors. Despite availability information, there no consensus about different...
Background/Objectives: Recent advances in the treatment of non-small cell lung cancer (NSCLC) have shifted from conventional chemotherapy to targeted therapies aimed at specific genetic mutations, particularly adenocarcinoma subtype. These improved overall survival and quality life. However, some patients still face barriers accessing these treatments due challenges diagnosing advanced-stage NSCLC. Limited tumor cellularity small biopsies cytological samples hinders ability perform further...
Metastatic colorectal cancer (mCRC) is associated with poor prognosis and limited options for later-line treatment. Regorafenib TAS-102 have shown significant benefit are recommended as treatment mCRC. This study aimed to investigate the progression-free survival (PFS) overall (OS) of patients mCRC treated sequentially after regorafenib progression. population-based cohort retrospectively collected data 30 at Harbin Medical University Cancer Hospital Affiliated Shanxi from January 1, 2020,...
Abstract Purpose: Recurrence is the major factor influencing clinical outcome of meningioma patients although exact relationship between primary and recurrent tumors still needs to be clarified. The aim present study analyze cytogenetic subsequent meningiomas developed within same individual. Experimental Design: Multicolor interphase fluorescence in situ hybridization was done for identification numerical abnormalities 12 chromosomes single-cell suspensions from 59 tumor samples...
Abstract The female predominance of meningiomas has been established, but how this is affected by hormones still under discussion. We analyzed the characteristics from male (n = 53) and 111) patients interphase fluorescence in situ hybridization (iFISH). In addition, a subgroup 45 (12 33 female) patients, tumors were hybridized with Affymetrix U133A chip. show higher frequency larger (p .01) intracranial .04) together relapse rate .03) than patients. Male had percentage del(1p36) <...