A5103453418- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- T-cell and B-cell Immunology
- Mast cells and histamine
- Immunodeficiency and Autoimmune Disorders
- Viral-associated cancers and disorders
- Urticaria and Related Conditions
- Immunotherapy and Immune Responses
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Complement system in diseases
- Asthma and respiratory diseases
- Dialysis and Renal Disease Management
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Immune Cell Function and Interaction
- Protein Degradation and Inhibitors
- Psoriasis: Treatment and Pathogenesis
- Salivary Gland Disorders and Functions
- Dermatology and Skin Diseases
- Bone Metabolism and Diseases
- Adenosine and Purinergic Signaling
- Cancer Cells and Metastasis
- Hematopoietic Stem Cell Transplantation
Administración Nacional de Laboratorios e Institutos de Salud
2025
Fundación Renal
2025
Hospital Universitario La Paz
2023
Centro de Investigación del Cáncer
2005-2015
Instituto de Investigación Biomédica de Salamanca
2013-2015
Universidad de Salamanca
2006-2015
Instituto de Biologia Molecular e Celular
2010-2013
Consejo Superior de Investigaciones Científicas
2008
Medicina
2008
Universidad de Murcia
2008
Abstract A heterogeneous spectrum of immunophenotypic abnormalities have been reported in myelodysplastic syndromes (MDS). However, most studies are restricted to the analysis CD34 + cells and/or other major subsets − cells, frequently not exploring diagnostic and prognostic impact immunophenotyping. Methods: We propose for first time an score (IS) based on altered distribution features maturing/mature compartments bone marrow (BM) hematopoietic 56 patients with MDS that could contribute a...
Abstract Background: Evaluation of the expression glycosylphosphatidylinositol‐anchored membrane proteins (GPI‐AP) is currently used for diagnosis paroxysmal nocturnal hemoglobinuria (PNH). In this study, we analyzed amount a wide variety GPI‐AP in different subsets hematopoietic cells present normal peripheral blood (PB), to establish their patterns and provide frame reference definition best combination PB cell be applied monitoring PNH. Results: Our results show variable distinct cells....
Abstract B‐cell chronic lymphocytic leukemia (B‐CLL) is a well‐defined clinical entity with heterogeneous molecular and cytogenetic features. Here, we analyze the impact of trisomy 12, del(13q), del(17p), del(11q) as determined by interphase fluorescence in situ hybridization analysis purified neoplastic B‐CLL cells on their immunophenotype, DNA ploidy status proliferative rate. Overall, 111 180 (62%) cases studied displayed one (50%) or more (12%) genetic abnormalities, del(13q) (35%) being...
SUMMARY Dendritic cells (DC) represent the most powerful professional antigen-presenting (APC) in immune system. The aim of present study was to analyse, on a single-cell basis by multiparametric flow cytometry with simultaneous four-colour staining and two-step acquisition procedure, immunophenotypic profile cytokine production DC from 67 normal whole peripheral blood (PB) samples. Two clearly different subsets HLA-II+/lineage− were identified their distinct phenotypic characteristics: one...
Abstract Background: Glycosylphosphatidylinositol‐anchored proteins (GPI‐AP) are a heterogeneous group of deficiently expressed in patients with paroxysmal nocturnal hemoglobinuria. Up till now, no study has been reported which the exact patterns expression large number GPI‐AP quantitatively evaluated normal bone marrow (BM) cells classified according to their lineage and maturation stage. Methods: In present study, we have analyzed eleven different (CD14, CD16, CD24, CD48, CD52, CD58, CD59,...
Background and Objectives Waldenström macroglobulinemia (WM) monoclonal gammopathy of undetermined significance (MGUS) are IgM-related disorders in which B cells harbor a unique clonotypic rearrangement the immunoglobulin heavy chain gene (IgH). The aim this study was to characterize IgH rearrangements larger series than any previously described.Design Methods Seventy-two patients with IgM (64 WM eight IgM-MGUS) were studied amplify sequence both VDJH DJH rearrangements. Twenty-nine them...
La pandemia por COVID-19, como evento disruptivo y singular, puso en jaque mucho más que los sistemas de salud países a nivel global. misma afectó diferencialmente aquellos grupos definidos alto riesgo enfermedad muerte [entre se encuentran las personas con diabetes mellitus (DM)]. El objetivo principal esta investigación es indagar padecimientos DM, recabando percepciones sobre su proceso salud-enfermedad-atención-cuidado el contexto la última COVID-19. Se incluyeron diagnóstico DM...
Chronic kidney disease-associated pruritus (CKD-aP), a persistent itching sensation, is prevalent among hemodialysis patients. This study aims to understand its prevalence, possible association with selected solutes, and impact on quality of life (QoL) in Involving 434 patients Spain, this observational employed survey based validated assessment tools, alongside demographic, clinical, biochemical data collection. The used statistical analyses examine the correlation between CKD-aP various...
Information about maturation of plasmacytoid dendritic cell precursors (pre-pDCs) in normal bone marrow (BM) remains limited.Immunophenotypical, morphologic, and functional changes associated with pre-pDCs were analyzed adult human BM (n = 45).Three pre-pDC stages, an increasingly higher degree maturity, systematically identified: CD34++/HLA-DR++/+++/CD123++/CD45+/++ (Stage I), CD34+/HLA-DR+/++/CD123++/+++/CD45+/++ II), CD34-/HLA-DR++/CD123++/+++/CD45++ III) cells. Lymphoid- early...
// Paloma Bárcena 1 , María Jara-Acevedo Dolores Tabernero 2 Antonio López Luz Sánchez Andrés C. García-Montero Noemí Muñoz-García Belén Vidriales 3 Artur Paiva 4 Quentin Lecrevisse Margarida Lima 5 Anton W. Langerak 6 Sebastian Böttcher 7 Jacques J.M. van Dongen Alberto Orfao 1, * Julia Almeida Cancer Research Centre (IBMCC, CSIC-USAL), Institute of Biomedical Salamanca (IBSAL), (NUCLEUS) and Department Medicine, University Salamanca, Spain Unity IECSCYL, Hospital IBSAL, Hematology Unidade...
Abstract Introduction Mesenchymal stem cells (MSCs) are multipotent capable of self-renewal and multilineage differentiation. Their multipotential capacity immunomodulatory properties have led to an increasing interest in their biological therapeutic applications. Currently, the definition MSCs relies on a combination phenotypic, morphological functional characteristics which typically evaluated upon vitro expansion, process that may ultimately lead modulation immunophenotypic, and/or...
Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by a deficient expression of glycosylphosphatidylinositol-anchored proteins (GPI-APs), due to somatic mutations the phosphatidylinositolglycan complementation Class A (PIG-A) gene.In this study, high number GPI-APs on different subsets peripheral blood (PB) cells from 14 PNH patients and their potential association with underlying genetic abnormalities has been analyzed.This study confirms existence variable patterns both major minor...
The authors' objective was to determine by 2-dimensional echo Doppler (2DECHO) the cardiac abnormalities in juvenile onset ankylosing spondylitis (JOAS) and adult (AOAS) male patients with long-term disease. Twenty JOAS, 31 AOAS, 20 healthy controls of same age gender without cardiopulmonary symptoms were studied. Using 2DECHO, heart dimensions determined according American Society Echocardiography guidelines. left ventricle ejection fraction (LVEF) calculated Teichholz's formula....
Summary Despite the effects of BCR ABL on cell proliferation, no study has compared proliferative rate different haematopoietic compartments from chronic myeloid leukaemia (CML) with those normal bone marrow (NBM). We comparatively analysed cycle distribution and / expression in BM cells 15 CML 11 NBM. Overall, our results showed similar indices patients However, CD34 + precursors displayed an increased proportion S G 2 /M‐phase ( P = 0·04), while significant differences were found between...
The coronavirus disease (COVID) pandemic has resulted in a major disruption healthcare that affected several medical and surgical specialties. European American Vascular Societies have proposed deferring the creation of an elective vascular access (VA) [autologous or prosthetic arteriovenous fistula (AVF) graft (AVG)] incident patients on haemodialysis (HD) era COVID pandemic. aim this study is to examine impact VA central venous catheter (CVC)-related hospitalizations complications HD...