A5053883418- Airway Management and Intubation Techniques
- Pain Mechanisms and Treatments
- Tracheal and airway disorders
- Anesthesia and Pain Management
- Neuroscience and Neuropharmacology Research
- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Foreign Body Medical Cases
- Neuroinflammation and Neurodegeneration Mechanisms
- Mitochondrial Function and Pathology
- Neurogenesis and neuroplasticity mechanisms
- Pharmacological Effects of Natural Compounds
- Anesthesia and Sedative Agents
- Respiratory Support and Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Mesenchymal stem cell research
- interferon and immune responses
- Nanoparticle-Based Drug Delivery
- Microtubule and mitosis dynamics
- Chemical Synthesis and Analysis
- Heme Oxygenase-1 and Carbon Monoxide
- Music Therapy and Health
- Simulation-Based Education in Healthcare
- Hereditary Neurological Disorders
- Drug Transport and Resistance Mechanisms
Huazhong University of Science and Technology
2016-2025
Tongji Hospital
2016-2025
Peking University
2019-2025
State Key Laboratory of Natural and Biomimetic Drugs
2022-2024
First People's Hospital of Jingzhou
2021
Shandong University
2014-2019
State Key Laboratory of Microbial Technology
2019
Peking University People's Hospital
2019
National Natural Science Foundation of China
2016
Université Félix Houphouët-Boigny
2014
Tracheal intubation in coronavirus disease 2019 (COVID-19) patients creates a risk to physiologically compromised and attending healthcare providers. Clinical information on airway management expert recommendations these are urgently needed. By analysing two-centre retrospective observational case series from Wuhan, China, panel of international experts discussed the results formulated consensus for tracheal COVID-19 patients. Of 202 undergoing emergency intubation, most were males (n=136;...
Abstract Background Activated astrocytes play important roles in chronic post-surgical pain (CPSP). Recent studies have shown reactive are classified into A1 and A2 phenotypes, but their precise CPSP remain unknown. In this study, we investigated the of spinal cord related mechanisms CPSP. Methods We used a skin/muscle incision retraction (SMIR) model to establish rat model. Microglia, CXCR7, phosphoinositide 3-kinase/Akt (PI3K/Akt) signaling pathways were regulated by intrathecal injections...
Carbohydrates are called the third chain of life. participate in many important biochemical functions living species, and biological information carried by them is several orders magnitude larger than that nucleic acids proteins. However, due to intrinsic complexity heterogeneity carbohydrate structures, furnishing pure structurally well-defined glycans for functional studies a formidable task, especially homogeneous large-size glycans. To address this issue, we have developed donor...
A novel chemoenzymatic approach for the synthesis of disialyl tetrasaccharide epitopes found as terminal oligosaccharides GD1α, GT1aα, and GQ1bα is described. It relies on chemical manipulation enzymatically generated trisaccharides conformationally constrained acceptors regioselective enzymatic α2–6-sialylation. This strategy provides a new route easy access to their derivatives.
Central post-stroke pain (CPSP) is a chronic and intolerable neuropathic syndrome following cerebral vascular insult, which negatively impacts the quality of life stroke survivors but currently lacks efficacious treatments. Though its underlying mechanism remains unclear, clinical features hyperalgesia allodynia indicate central sensitization due to excessive neuroinflammation. Recently, crosslink between neuroinflammation endoplasmic reticulum (ER) stress has been identified in diverse...
The first bacterial α2–6-sialyltransferase cloned from Photobacterium damselae (Pd2,6ST) has been widely applied for the synthesis of various α2–6-linked sialosides. However, extreme substrate flexibility Pd2,6ST makes it unsuitable site-specific α2–6-sialylation complex substrates containing multiple galactose and/or N-acetylgalactosamine units. To tackle this problem, a general redox-controlled sialylation strategy using is described. This approach features enzymatic oxidation units to...
We compared the McGrath® Series 5 videolaryngoscope with Macintosh laryngoscope for double-lumen tracheal tube placement in patients a predicted good glottic view on assessment of airway. An initial laryngoscopy was performed using laryngoscope; 96 Cormack and Lehane grade-1 or -2a views were randomly assigned to undergo intubation either McGrath device. Compared laryngoscope, provided more (47 (97.9%) vs 29 (60.4%), p < 0.05), longer mean (SD) time (39.6 (10.0) s 24.4 (7.3) s, 0.05) higher...
Morphine tolerance is a classic, challenging clinical issue. However, the mechanism underlying this phenomenon remains poorly understood. Recently, studies have shown that ferroptosis correlates with drug resistance. Therefore, study investigated whether spinal cord contributes to morphine tolerance. C57BL/6 mice were continuously subcutaneously injected morphine, or without inhibitor liproxstatin-1. We found chronic exposure led antinociception tolerance, accompanied by loss of neurons,...
The effects of different positional relationships between the probe, needle, and puncture model on in-plane performance have not been fully evaluated. In this simulation study, we used a 4-period crossover design to compare learning curves ultrasound-guided needle placement among 4 modes by novices. Forty residents were randomly assigned receive training in one according orientation probe operator: horizontal phantom-parallel (HP), phantom-vertical (HV), vertical (VP), (VV). They allowed 10...