A5100335224- Cancer, Hypoxia, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Mitochondrial Function and Pathology
- Liver physiology and pathology
- Cancer Research and Treatments
- Lung Cancer Diagnosis and Treatment
- Liver Disease and Transplantation
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Cancer, Lipids, and Metabolism
- Pulmonary Hypertension Research and Treatments
- Gallbladder and Bile Duct Disorders
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Glioma Diagnosis and Treatment
- Advanced Queuing Theory Analysis
- Healthcare Operations and Scheduling Optimization
- Supply Chain and Inventory Management
- Venous Thromboembolism Diagnosis and Management
- Pediatric Hepatobiliary Diseases and Treatments
The University of Texas Southwestern Medical Center
2020-2025
Xiangya Hospital Central South University
2021-2025
Central South University
2021-2025
Sixth Affiliated Hospital of Sun Yat-sen University
2013-2024
Sun Yat-sen University
2012-2024
Panyu Hospital of Chinese Medicine
2024
Memorial Hospital
2024
Chinese PLA General Hospital
2023-2024
Shandong Tumor Hospital
2012-2024
Shandong First Medical University
2012-2024
Abstract Branched-chain amino acid transaminase 1 (BCAT1) is upregulated selectively in human isocitrate dehydrogenase (IDH) wildtype (WT) but not mutant glioblastoma multiforme (GBM) and promotes IDHWT GBM growth. Through a metabolic synthetic lethal screen, we report here that α-ketoglutarate (AKG) kills cells when BCAT1 protein lost, which reversed by reexpression of or supplementation with branched-chain α-ketoacids (BCKA), downstream products BCAT1. In patient-derived tumors vitro vivo,...
Genetic mutations in apoptosis-inducing factor (AIF) have a strong association with mitochondrial disorders; however, little is known about the aberrant splicing variants affected patients and how these contribute to dysfunction brain development defects. We identified pathologic AIF3/AIF3-like postmortem tissues of pediatric individuals disorders. Mutations AIFM1 exon-2/3 increase risks. AIF3-splicing disrupts complexes, membrane potential, respiration, causing Mechanistically, AIF...
Pyruvate kinase type M2 (PKM2) has been reported to be involved in aerobic glycolysis and cell growth various tumors. However, the expression pattern of PKM2 colorectal cancer (CRC) correlation between CRC remains unclear. The aim this study is investigate its possible role CRC. We found that was increased associated with later stage lymph metastasis Knockdown suppressed decreased lactate production colon RKO cells. repressed proliferation migration Inhibition xenograft tumor cells vivo....
Abstract Background We explore the clinical and prognostic significance of expression vascular endothelial growth factor receptor (VEGFR)-2, platelet-derived (PDGFR)-β, c-Met in patients with hepatocellular carcinoma (HCC). Methods The VEGFR-2, PDGFR-β, were determined by immunohistochemical examination tissues 93 HCC patients. relationships these markers clinicopathological factors prognosis then analyzed. Results High was found 86%, 19.4%, 80.6% patients, respectively. Expression VEGFR-2...
Hepatocellular carcinoma (HCC) is one of the most common cancers and third leading cause death from cancer worldwide. HCC has a very poor prognosis because tumor invasiveness, frequent intrahepatic spread, extrahepatic metastasis. The molecular mechanism invasiveness metastasis poorly understood. homeobox protein PROX1 required for hepatocyte migration during mouse embryonic liver development. In this study, we show that high expression in primary tissues associated with significantly worse...
Activation of pulmonary adventitial fibroblasts plays a key role in the vascular remodeling hypoxic hypertension. Previous studies showed that miRNAs participated regulation fibroblast activation. This study explored miR-29 activation and therapeutic potential We found hypoxia-induced was accompanied with drastic decrease miR-29a-3p expression. Knockdown hypoxia-inducible factor-1 α or Smad3 reversed miR-29-3p cultured fibroblasts. In vitro, mimic inhibited proliferation, migration,...
The aim of this study is to explore the possible role HIF-1α in glucose metabolism, proliferation and apoptosis pancreatic cancerous cells.The BxPC-3 cells were cultured normoxia or hypoxia (3% O2), respectively. Cell was determined by MTT assay, Annexin V/PI staining. Expression Pyruvate dehydrogenase kinase (PDK1), Lactate (LDHA), pyruvate M2 (PKM2) citrate synthase (CS) Western-blot Realtime PCR.Under hypoxia, expression lactate production increased. metabolic enzymes PDK1, LDHA, PKM2...
Recruitment of RNA polymerase II to hypoxia-inducible factor (HIF) target genes under normoxia is a prerequisite for HIF-mediated transactivation. However, the underlying mechanism this recruitment remains unknown. Here we report that chromodomain helicase DNA-binding protein 4 (CHD4) physically interacts with α and β subunits HIF1 HIF2 enhances HIF-driven transcriptional programs promote breast cancer progression. Loss HIF1/2α abolished CHD4-mediated tumor growth in mice. In cells normoxia,...
To understand the proportion of uHCC (unresectable hepatocellular carcinoma) patients who achieve successful conversion resection in a high-volume setting with state art treatment options.We retrospectively reviewed all HCC hospitalized to our center from June 1st, 2019 2022. Conversion rate, clinicopathological features, response systemic and/or loco-regional therapy and surgical outcomes were analyzed.A total 1,904 identified, 1672 receiving anti-HCC treatment. 328 considered up-front...
Motivated by the increasing use of online appointment booking platforms, we study how to offer slots customers maximize total number booked. We develop two models, nonsequential offering and sequential offering, capture different types interactions between scheduling system. In these scheduler offers either a single set for arriving customer choose from or multiple sets in sequence, respectively. For model, identify static randomized policy, which is asymptotically optimal when system demand...
Hypoxia-inducible factor-1(HIF-1) is a major determinant of invasion and metastasis in several tumor types. We previously reported that HIF-1α contributed to multidrug resistance gastric cancer. However, the role HIF-2α on progression cancer seldom reported. In this study, we firstly examined possible process invasiveness cancer, using immunohistochemistry 80 tissues, Western blot real-time PCR 8 fresh tissues. The results showed significantly correlated with clinical stage were highly...
To evaluate the effect of Pringle maneuver time on tumor recurrence following liver resection in patients with hepatocellular carcinoma (HCC).In this single-center study, we retrospectively evaluated HCC over a 10-year period from 1999 to 2008 using Cox regression analysis.This study enrolled total 2,368 patients. A 15 min was associated (log likelihood ratio test, P = 0.001). less than not significant risk factor for (hazard ratio, HR 0.97, 0.708). However, greater an independent predictor...
This study evaluated the efficacy and safety of 3D printing technology combined with percutaneous nephrolithotomy in treatment complex renal calculi. Ninety patients calculi were randomly divided into a group (45 patients) control patients). In group, patient-specific 1:1 model was established based on patient's thin-layer CT scanning data. A used for preoperative communication between doctors patients. Preoperative puncture training, channel design, residual stone prediction, performed...
Inhibiting hypoxia-inducible factor (HIF)-1α activity has been proposed as a novel therapeutic target in LPS-induced sepsis syndrome. We have reported that tanshinone IIA (TIIA) can reduce lethality and lung injury mice, but the precise mechanisms not fully described. Therefore, present study investigated whether protective effect of TIIA was related to inhibition HIF-1α expression what accounted for it. This showed pretreatment improved biochemical cellular changes reduced production...
Over 200 cases of undifferentiated embryonal sarcoma the liver (UESL) have been reported since 1978 when this disease was first described. In present study, we describe a case UESL in 7-year-old female, whose initial symptoms included swelling upper abdomen and palpable enormous irregular tumor. A magnetic resonance imaging (MRI) examination revealed massive focal lesion right lobe liver. Hepatic malignant tumor with high possibility hepatoblastoma diagnosed. The surgically removed confirmed...