A5100462577- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Autophagy in Disease and Therapy
- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Ovarian cancer diagnosis and treatment
- Cancer, Hypoxia, and Metabolism
- Gestational Diabetes Research and Management
- Spinal Cord Injury Research
- Pediatric Hepatobiliary Diseases and Treatments
- Bladder and Urothelial Cancer Treatments
- Metabolism, Diabetes, and Cancer
- Endometrial and Cervical Cancer Treatments
- Mesenchymal stem cell research
- RNA Research and Splicing
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA Interference and Gene Delivery
- Hepatocellular Carcinoma Treatment and Prognosis
- Particle physics theoretical and experimental studies
- Immune cells in cancer
- Genetics and Neurodevelopmental Disorders
Fraternal Order of Eagles
2018-2025
Hubei University of Chinese Medicine
2025
Institute of Zoology
2022-2025
Chinese Academy of Sciences
2022-2025
Zhuhai Institute of Advanced Technology
2025
University of Chinese Academy of Sciences
2013-2025
First People's Hospital of Jingzhou
2025
Yangtze University
2025
University of Iowa
2017-2025
PLA Academy of Military Science
2024-2025
Highlights•LINC00116 encodes a single-pass transmembrane protein known as mitoregulin (Mtln)•Mtln appears to be sticky inner mitochondrial membrane that binds cardiolipin•Mtln levels influence respiration, ROS, and Ca2+ retention capacity•Mtln-KO mice exhibit deficiencies in FAO, mCa2+ retention, supercomplexesSummaryMitochondria are composed of many small proteins control synthesis, complex assembly, metabolism, ion reactive oxygen species (ROS) handling. We show skeletal muscle-...
The SARS-CoV-2 main protease (Mpro) is the drug target of Pfizer's oral nirmatrelvir. emergence variants with mutations in Mpro raised alarm potential resistance. To identify clinically relevant drug-resistant mutants, we systematically characterized 102 naturally occurring mutants located at 12 residues nirmatrelvir-binding site, among which 22 5 residues, including S144M/F/A/G/Y, M165T, E166 V/G/A, H172Q/F, and Q192T/S/L/A/I/P/H/V/W/C/F, showed comparable enzymatic activity to wild-type...
Summary Sweet cherry is a diploid tree species and its fruit skin has rich colours from yellow to blush dark red. The colour closely related anthocyanin biosynthesis mainly regulated at the transcriptional level by transcription factors that regulate expression of multiple structural genes. However, genetic molecular bases how these genes ultimately determine traits remain poorly understood. Here, our evidences identified R 2 3 MYB factor P av 10.1 involved in pathway determines sweet...
ABSTRACT The SARS-CoV-2 main protease (M pro ) is the drug target of Pfizer’s oral Paxlovid. emergence variants with mutations in M raised alarm potential resistance. In this study, we identified 100 naturally occurring located at nirmatrelvir binding site, among which 20 mutants, including S144M/F/A/G/Y, M165T, E166G, H172Q/F, and Q192T/S/L/A/I/P/H/V/W/C/F, showed comparable enzymatic activity to wild-type (k cat /K m <10-fold change) resistance (K i >10-fold increase). X-ray crystal...
Tibetans are well adapted to high-altitude hypoxic conditions, and in recent genome-wide scans, many candidate genes have been reported involved the physiological response conditions. However, limited sequence variations analyzed previous studies would not be sufficient identify causal mutations. Here we conducted resequencing of entire genomic region (59.4 kb) gene EGLN1 (one top candidates from scans) identified 185 variations, including 13 novel (12 substitutions 1 insertion or deletion)....
Abstract Glioma is the most common malignant tumor in central nervous system. Altered long noncoding RNAs (lncRNAs) are playing regulatory roles physiological and pathogenic processes cancer. Here, we uncovered a differentially expressed lncRNA called brain cytoplasmic RNA 1 (BCYRN1), elucidated its function molecular mechanism progression development of glioma. Three fresh tissues from glioma patients three normal craniocerebral trauma were prepared for high-throughput sequencing....
Cholangiocarcinoma (CCA) is a highly aggressive malignancy with extremely poor prognoses. The oncogenic role and prognostic value of c-Myc in CCA not well elucidated. WD repeat domain 5 (WDR5) critical regulatory factor directly interacting to regulate recruitment at chromosomal locations, but the interaction WDR5 was uncovered. In our study, we detected expression all types, including intrahepatic (iCCA), perihilar (pCCA), distal (dCCA) CCA, evaluated their significance. Consequently,...
The drivers of immune evasion are not entirely clear, limiting the success cancer immunotherapies. Here we applied single-cell spatial and perturbational transcriptomics to delineate in high-grade serous tubo-ovarian cancer. To this end, first mapped organization by profiling more than 2.5 million cells situ 130 tumors from 94 patients. This revealed a malignant cell state that reflects tumor genetics is predictive T natural killer infiltration levels response checkpoint blockade. We then...
Compound C is commonly used as an inhibitor of AMP-activated protein kinase (AMPK), which serves a key energy sensor in cells. In this study, we found that treatment MCF7 cells led to Bax redistribution from the cytoplasm mitochondria and cell death. However, effect does not involve AMPK. addition, with compound leads enhanced ceramide production. Analyses by quantitative PCR synthase activity assay suggest 5 (LASS/CerS 5) involved C-induced upregulation. Downregulation LASS/CerS was...
Poor management of DM causes cognitive impairment while the mechanism is still unconfirmed. The aim present study was to investigate activation C/EBP Homology Protein (CHOP), prominent mediator endoplasmic reticulum (ER) stress-induced apoptosis under hyperglycemia. We employed streptozotocin- (STZ-) induced diabetic rats explore ability learning and memory by Morris water maze test. ultrastructure hippocampus in cultured neurons high glucose medium were observed transmission electron...
To produce chemicals and fuels from renewable resources, various strategies genetic tools have been developed to redesign pathways optimize the metabolic flux in microorganisms. However, most successful cases, target are synthesized through a linear pathway, regular methodologies for identification of bottlenecks optimization multibranched multilevel regulated pathways, such as l-methionine biosynthetic rarely reported. In present study, systematic analysis strategy was employed gradually...
Abstract Lung cancer is the leading cause of cancer-related deaths worldwide, with 50–70% patients suffering from bone metastasis. Accumulating evidence has demonstrated that miRNAs are involved in cell proliferation, migration, and invasion malignancy, such as lung In present study, we reduced miR-192-5p increased TRIM44 levels were associated migration cancer. Furthermore, potential functions explored A549 NCI-H1299 cells. We found upregulation suppressed tumour behaviours To further...
Abstract Background Glioblastoma is the most common primary malignant intracranial tumor with poor clinical prognosis in adults. Accumulating evidence indicates that long non-coding RNAs (lncRNAs) function as important regulators cancer progression, including glioblastoma. Here, we identified a new lncRNA LPP antisense RNA-2 (LPP-AS2) and investigated its mechanism development of glioma. Methods High-throughput RNA sequencing was performed to discriminate differentially expressed lncRNAs...
Myocardial fibrosis and cardiac dysfunction are the main characteristics of diabetic heart disease. However, molecular mechanisms underlying myocardial remain unclear.This study aimed to investigate heterogeneity fibroblasts in mice its possible mechanism development fibrosis.We established a mouse model by injecting with streptozotocin. The overall cell profiles hearts were analyzed using single-cell RNA transcriptomic techniques. Cardiac function was evaluated echocardiography. assessed...
Although it has been reported that deficiency of toll-like receptor 4 (TLR4) is associated with reduced atherosclerosis in atherosclerosis-prone mice and attenuated pro-inflammatory state diabetic mice, remains undetermined whether treatment a TLR4 antagonist reduces nondiabetic or have expression. In this study, we determined the effect Rhodobacter sphaeroides lipopolysaccharide (Rs-LPS), an established antagonist, on early-stage streptozotocin-induced apolipoprotein E-deficient ( Apoe −/−...
Diabetes is the most common metabolic disease with many chronic complications, and cognitive disorders are one of complications in patients diabetes. Previous studies have showed that autophagy played important roles progression syndrome, diabetes other diseases. So we investigated whether aged diabetic mice prone to be associated affective Beclin-1-mediated might involved thepahological process.High-fat diet/streptozotocin (STZ) injection-induced C57 were adopted this study. Cognitive...
Metabolic dysfunction is a hallmark of gastric cancer (GC). In this study, we reported the identification Calcium Binding Protein 39-Like (CAB39L) as novel regulator tumor metabolism in GC. CAB39L mRNA was frequently silenced by promoter methylation GC cell lines and tissues. Functional studies suggested that functions suppressor, overexpression elicited suppression multiple phenotypes both cells an orthotopic mouse model; whilst its knockdown promoted tumorigenesis. Mechanistically,...