A5068839920- Quantum Information and Cryptography
- Quantum Computing Algorithms and Architecture
- Quantum Mechanics and Applications
- Orthopedic Surgery and Rehabilitation
- High Altitude and Hypoxia
- Pulmonary Hypertension Research and Treatments
- Foot and Ankle Surgery
- Cancer, Hypoxia, and Metabolism
- Laser Material Processing Techniques
- Fault Detection and Control Systems
- Forensic and Genetic Research
- Quantum many-body systems
- Pancreatic function and diabetes
- Microbial Community Ecology and Physiology
- Adipose Tissue and Metabolism
- Nonlinear Optical Materials Studies
- Mineral Processing and Grinding
- Quantum chaos and dynamical systems
- Protist diversity and phylogeny
- Bone fractures and treatments
- Neuroscience of respiration and sleep
- Cholinesterase and Neurodegenerative Diseases
- Diabetic Foot Ulcer Assessment and Management
- Cardiovascular Function and Risk Factors
- Mycorrhizal Fungi and Plant Interactions
Nankai University
2025
Anhui Normal University
2024-2025
Institute of Hydrobiology
2024-2025
Ministry of Education of the People's Republic of China
2024-2025
Fuzhou Maternity and Child Health Care Hospital
2025
Beijing Institute of Technology
2023-2025
Huazhong University of Science and Technology
2025
Hubei Cancer Hospital
2025
Chinese Academy of Sciences
2010-2024
PLA Information Engineering University
2024
Modern humans have occupied almost all possible environments globally since exiting Africa about 100,000 years ago. Both behavioral and biological adaptations contributed to their success in surviving the rigors of climatic extremes, including cold, strong ultraviolet radiation, high altitude. Among these environmental stresses, high-altitude hypoxia is only condition which traditional technology incapable mediating its effects. Inhabiting at >3,000-m plateau, Tibetan population provides a...
Significance Fossil evidence shows that red algae (Rhodophyta) are one of the most ancient multicellular lineages. Their ecological, evolutionary, and commercial importance notwithstanding, few algal nuclear genomes have been sequenced. Our analyses Porphyra umbilicalis genome provide insights into how this macrophyte thrives in stressful intertidal zone basis for its nutritional value as human food. Many novel traits (e.g., cytoskeletal organization, calcium signaling pathways) we find...
Tibetans live on the highest plateau in world, their current population size is approximately 5 million, and most of them at an altitude exceeding 3,500 m. Therefore, Tibetan Plateau a remarkable area for cultural biological studies human history. However, chronological profile Plateau’s colonization remains unsolved question prehistory. To reconstruct prehistoric demographic history modern humans Plateau, we systematically sampled 6,109 individuals from 41 geographic populations across...
Tibetans are well adapted to high-altitude hypoxic conditions, and in recent genome-wide scans, many candidate genes have been reported involved the physiological response conditions. However, limited sequence variations analyzed previous studies would not be sufficient identify causal mutations. Here we conducted resequencing of entire genomic region (59.4 kb) gene EGLN1 (one top candidates from scans) identified 185 variations, including 13 novel (12 substitutions 1 insertion or deletion)....
Abstract Background The phylogeography of the Y chromosome in Asia previously suggested that modern humans African origin initially settled mainland southern East Asia, and about 25,000–30,000 years ago, migrated northward, spreading throughout Asia. However, fragmented distribution one Asian specific lineage (D-M174), which is found at high frequencies only Tibet, Japan Andaman Islands, inconsistent with this scenario. Results In study, we collected more than 5,000 male samples from 73...
Pulmonary arterial hypertension (PAH) is a devastating disease characterized by progressive vasoconstriction and obliterative vascular remodeling that leads to right heart failure (RHF) death. Current therapies do not target RHF, result in only modest improvement of morbidity mortality.
Abstract Background The emergence of agriculture about 10,000 years ago marks a dramatic change in human evolutionary history. diet shift societies might have great impact on the genetic makeup Neolithic populations. regionally restricted enrichment class I alcohol dehydrogenase sequence polymorphism (ADH1BArg47His) southern China and adjacent areas suggests Darwinian positive selection this locus during time though driving force is yet to be disclosed. Results We studied total 38...
Tibetans are well adapted to the hypoxic environments at high altitude, yet molecular mechanism of this adaptation remains elusive. We reported comprehensive genetic and functional analyses EPAS1, a gene encoding hypoxia inducible factor 2α (HIF-2α) with strongest signal selection in previous genome-wide scans Tibetans. showed that Tibetan-enriched EPAS1 variants down-regulate expression human umbilical endothelial cells placentas. Heterozygous knockout mice display blunted physiological...
A dynamical quantum phase transition can occur during time evolution of sudden quenched systems across a transition. It corresponds to the nonanalytic behavior at critical rate function state return amplitude, analogous nonanalyticity free energy density temperature in macroscopic systems. variety many-body be represented momentum space as spin-1/2 evolving on Bloch sphere, where each mode is decoupled and thus simulated independently by single qubit. Here, we report observation...
We investigate the maximally coherent states to provide a refinement in quantifying coherence and give measure-independent definition of coherence-preserving operations. A state can be considered as resource create arbitrary quantum same dimension by merely incoherent propose that only should achieve maximal value for measure use this condition an additional criterion measures obtain which excludes invalid inefficient measures. Under new criterion, we then operations, play similar role...
Highlights A surface with periodic hydrophobicity gradient (SPHG) is fabricated by shaped femtosecond laser. The directional self-propulsion of the Leidenfrost droplets realized. viscous force between gas and liquid used to drive droplet move. brand-new method for controlling movement provided.
Polyploidy is increasingly seen as a driver of both evolutionary innovation and ecological success. One source polyploid organisms' successes may be their origins in the merging mixing genomes from two different species (e.g., allopolyploidy). Using POInT (the Polyploid Orthology Inference Tool), we model resolution three allopolyploidy events, one bakers' yeast (Saccharomyces cerevisiae), thale cress (Arabidopsis thaliana) grasses including Sorghum bicolor. Analyzing total 21 genomes,...
Skin lightening among Eurasians is thought to have been a convergence occurring independently in Europe and East Asia as an adaptation high latitude environments. Among Europeans, several genes responsible for such found, but the information available Asians much more limited. Here, genome-wide comparison between dark-skinned Africans Austro-Asiatic speaking aborigines light-skinned northern Han Chinese identified pigmentation gene OCA2, showing unusually deep allelic divergence these...
Abstract Human estrogen receptor alpha (hERα) is a hormone-responsive nuclear (NR) involved in cell growth and survival that contains both DNA-binding domain (DBD) ligand-binding (LBD). Functionally relevant inter-domain interactions between the DBD LBD have been observed several other NRs, but for hERα, detailed structural architecture of complex unknown. By utilizing integrated complementary techniques small-angle X-ray scattering, hydroxyl radical protein footprinting computational...
Strong ultraviolet (UV) radiation at high altitude imposes a serious selective pressure, which may induce skin pigmentation adaptation of indigenous populations. We conducted phenotyping and genome-wide analysis Tibetans in order to understand the underlying mechanism UV radiation. observe that have darker baseline color compared with lowland Han Chinese, as well an improved tanning ability, suggesting two-level boost their melanin production. A search for responsible genes identifies GNPAT...
Microbial communities in the world ocean are affected strongly by oceanic circulation, creating characteristic marine biomes. The high connectivity of most makes it difficult to disentangle selective retention colonizing genotypes (with traits suited biome specific conditions) from evolutionary selection, which would act on founder over time. Arctic Ocean is exceptional with limited exchange other oceans and ice covered since last age. To test whether microalgal lineages evolved apart algae...
Abstract Sherpas living around the Himalayas are renowned as high-altitude mountain climbers but when and where Sherpa people originated from remains contentious. In this study, we collected DNA samples 582 in Nepal Tibet Autonomous Region of China to study genetic diversity both their maternal (mitochondrial DNA) paternal (Y chromosome) lineages. Analysis showed that share most lineages with indigenous Tibetans, representing a recently derived sub-lineage. The estimated ages two...
In non-Hermitian systems, the phenomenon that bulk-band eigenstates are accumulated at boundaries of systems under open boundary conditions is called skin effect (NHSE), which one most iconic and important features a system. this work, we investigate fate NHSE in presence electric fields by analytically calculating dynamical evolution an initial bulk state numerically computing spectral winding number, distributions eigenstates, as well evolutions. We show abundant manipulation effects dc ac...
We investigate a non-Hermitian model featuring nonreciprocal gradient hoppings. Through an in-depth analysis of the Liouvillian spectrum and dynamics, we confirm emergence skin effect resulting from nature hoppings in this model. Furthermore, observe that presence hopping strength leads to accelerated relaxation time for system. numerical investigations gap, time, steady-state localization length, discover cannot be explained by currently established relationship associated with effect. This...
The Y-chromosome haplogroup N-M231 (Hg N) is distributed widely in eastern and central Asia, Siberia, as well northern Europe. Previous studies suggested a counterclockwise prehistoric migration of Hg N from Asia to However, the root this Y chromosome lineage its detailed dispersal pattern across are still unclear. We analyzed profiles phylogeographic patterns 1,570 individuals 20,826 males 359 populations Eurasia. first genotyped 6,371 169 China Cambodia, generated data 360 individuals,...