A5100323517- melanin and skin pigmentation
- Biochemical Analysis and Sensing Techniques
- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Sperm and Testicular Function
- Epigenetics and DNA Methylation
- Animal Genetics and Reproduction
- Genetic diversity and population structure
- Signaling Pathways in Disease
- Antioxidant Activity and Oxidative Stress
- Plant Gene Expression Analysis
- Cancer-related gene regulation
- Molecular Biology Techniques and Applications
- Plant biochemistry and biosynthesis
- Phytochemicals and Antioxidant Activities
- Cellular Mechanics and Interactions
- Animal Behavior and Welfare Studies
- Reproductive Biology and Fertility
- interferon and immune responses
- Silk-based biomaterials and applications
- Histone Deacetylase Inhibitors Research
- Pancreatic function and diabetes
- Galectins and Cancer Biology
- Hops Chemistry and Applications
- Meat and Animal Product Quality
Anhui Medical University
2023-2024
South China Agricultural University
2021-2022
Shanghai Academy of Agricultural Sciences
2021
Jiangxi Agricultural University
2019
Kunming Institute of Zoology
2016
Chinese Academy of Sciences
2016
University of Michigan
2005
Nagoya City University
2000
Skin lightening among Eurasians is thought to have been a convergence occurring independently in Europe and East Asia as an adaptation high latitude environments. Among Europeans, several genes responsible for such found, but the information available Asians much more limited. Here, genome-wide comparison between dark-skinned Africans Austro-Asiatic speaking aborigines light-skinned northern Han Chinese identified pigmentation gene OCA2, showing unusually deep allelic divergence these...
Abstract Genome‐wide SNP profiling has yielded insights into the genetic structure of China indigenous pigs, but focused on a limited number populations. Here, we present an analysis population and signals positive selection in 42 Chinese pig populations that represent most extensive phenotypic diversity China, using genotype data 1.1 million SNPs customized Beadchips. This unravels fine‐scale diversity, phylogenic relationships, these populations, which shows remarkably concordance between...
Abstract The conserved histone variant H2A.Z is essential for transcriptional regulation; defense responses; and various biological processes in plants, such as growth, development, flowering. However, little known about how affects the developmental process ripening of tomato fruits. Here, we utilized CRISPR/Cas9 gene-editing system to generate a sl_hta9 sl_hta11 double-mutant, designated sl_h2a.z , found that these two mutations led significant reduction fresh weight Subsequent messenger...
Abstract Background The dazzling phenotypic characteristics of male Indian peafowl (Pavo cristatus) are attractive both to the female species and humans. However, little is known about evolution phenotype phylogeny these birds at whole-genome level. So far, there no reports regarding genetic mechanism formation leucism plumage in this variant peafowl. Results A draft genome was assembled, with a size 1.05 Gb (the sequencing depth 362×), contig scaffold N50 were up 6.2 11.4 Mb, respectively....
Duroc × (Landrace Large White) hybrid pig (DLY) is the most popular commercial pigs in Chinese industry. DLY are usually white but sometimes show colored phenotypes. Colored not favored by slaughterhouses and retailers, thus causing certain economic losses to farmers China. In this study, we first conducted genome-wide association study RNA sequencing demonstrate that KIT variants responsible for diversifying coat color phenotypes segregating a population. We then defined precise sizes...
The domestication and artificial selection of wild boars have led to dramatic morphological behavioral changes, especially in East Chinese (ECN) pigs. Here, we provide insights into the population structure current genetic diversity representative ECN pig breeds. We identify a 500-kb region containing six tooth development-relevant genes with almost completely different haplotypes between pigs or European domestic Notably, c.195A>G missense mutation exon 2 AMBN may cause alterations its...
Abstract Tyrosinase inhibitory and anti-tumor promoting activities of 14 compounds isolated from safflower cotton oil cakes were evaluated together with the two genins glycosides, trachorogenin (8a) quercetin (12a). Catechin (11) (12a) showed moderate tyrosinase activity. N-(p-Coumaroyl)serotonin (1) its 5-O-glucoside (3) exhibited weak anti-tyrosinase activity, but potent activity on melanine production in assay. Serotonin derivatives (1-4). 2-hydroxyarctiin (8), matairesinol glycoside (9)...
C57BL/6 laboratory mice usually show black coat color. We observed a dilute (gray) color phenotype in progenies of two mice. This is inherited an autosomal recessive mode. To uncover the molecular mechanism underlying this naturally occurring phenotypic variation, we performed whole-genome sequencing (25×) on 10 offspring founder The DNA and additional RNA-Seq data reveal that Myo5a gene responsible for dilution mice, novel mutations are likely causal. further reverse...
Abstract Lung cancer is one of the most prevalent human cancers with a high lethality rate worldwide. In this study, we demonstrated that GSE1 (genetic suppressor element 1) expression aberrantly upregulated in lung adenocarcinoma and depletion inhibits proliferation migration both A549 H1299 cells. Immunoprecipitation assays interacts histone deacetylase 1 (HDAC1) other BRAF–HDAC complex (BHC) components The transcriptome GSE1‐knockdown cells indicated 207 genes were 159 downregulated based...
The blue-crowned laughingthrush (Garrulax courtoisi) is a critically endangered songbird endemic to Wuyuan, China, with population of ~323 individuals. It has attracted widespread attention, but the lack published genome limited research and species protection.
Asthenoteratozoospermia is a major cause of male infertility. Thus far, the identified related genes can explain only small share asthenoteratozoospermia cases, suggesting involvement other genes. The transmembrane protein TMEM232 highly expressed in mouse testes. In present study, to determine its function testes, we constructed Tmem232-null model using CRISPR-Cas9 technology. Tmem232 knockout (KO) mice was completely infertile, and their sperm were immotile, with morphological defects...
To detect potential mutation of the WAS gene in a Chinese family affected with Wiskott-Aldrich syndrome.Peripheral blood samples were collected from proband and his members. All exons flanking regions subjected to PCR amplification - Sanger sequencing as well restriction endonuclease analysis. Plasma level B-cell activating factor (BAFF) was also determined for all members.A hemizygous (c.257G>A) identified patients family, which patient's mother heterozygous. The same not found among...
Abstract Background: Pudong white (PDW) pigs originating from Shanghai, are the only Chinese indigenous with coat color except Rongchang (RC) pigs. However, there is limited information about its overall genetic structure, relationship other breeds especially East (ECN) and European pig due to of PDW. Whole-genome sequencing provides effective approach get unique genome. The high-depth whole-genome data 26 global breeds, Wild boars (EWB), (CWB) out group (OUT) were implemented detect...