A5100326589- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Gut microbiota and health
- Tryptophan and brain disorders
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Kidney Stones and Urolithiasis Treatments
- Microbial Metabolic Engineering and Bioproduction
- Connective tissue disorders research
- Urinary Tract Infections Management
- RNA modifications and cancer
- Probiotics and Fermented Foods
- Biofuel production and bioconversion
- Bladder and Urothelial Cancer Treatments
- Genetic Syndromes and Imprinting
- Nuclear Receptors and Signaling
- Hippo pathway signaling and YAP/TAZ
- Cardiac electrophysiology and arrhythmias
- Plant Genetic and Mutation Studies
- Peroxisome Proliferator-Activated Receptors
- Electrical Fault Detection and Protection
Nantong University
2022-2025
Southwest Medical University
2021-2025
Tsinghua University
2025
Yunnan Agricultural University
2025
Fudan University
2023
State Key Laboratory of Medical Neurobiology
2023
Jiangnan University
2023
Shenzhen Bay Laboratory
2023
Sichuan University
2016-2023
Nanjing Medical University
2020-2022
Ferredoxin 1 (FDX1) functions by transferring electrons from NADPH to mitochondrial cytochrome P450 via the ferredoxin reductase and is key regulator in copper-dependent cell death. Although mounting evidence supports a vital role for FDX1 tumorigenesis of some cancers, no pan-cancer analysis has been reported. Therefore, we aimed explore prognostic value investigate its potential immune function. Based on data The Cancer Genome Atlas, Cell Line Encyclopedia, Genotype Tissue-Expression,...
Prostate cancer was the fourth most diagnosed worldwide in 2022. Radical treatments and androgen deprivation therapy benefit newly patients but impact quality of life, often leading to castration-resistant prostate cancer. Short-term dietary changes significantly affect gut microbiota, which differs markedly between healthy individuals, impacting both progression treatment response. A high-choline diet increases risk fatal cancer, potentially mediated by conversion choline trimethylamine...
Prostate cancer (PCa) is the most frequently diagnosed malignancy in men, and its mechanism remains poorly understood. Therefore, it urgent to discover potential novel diagnostic biomarkers therapeutic targets that can potentially facilitate development of efficient anticancer strategies.A series functional vitro vivo experiments were conducted evaluate biological behaviors PCa cells. RNA pulldown, Western blot, luciferase reporter, immunohistochemistry chromatin immunoprecipitation assays...
Liver fibrosis, one of the main histological determinants various chronic liver diseases, currently lacks effective treatment. Hepatic stellate cells (HSCs) are pivotal in production extracellular matrix and amplify fibrogenic response. Inhibiting activation HSCs or promoting senescence activated is crucial for regression fibrosis. The ATPase p97, also known as valosin-containing protein (VCP), a central component ubiquitin-proteasome system, it regulates numerous cellular processes by...
Abstract Background Kidney stone disease (KSD) is more common in individuals with hypertension (HTN) than normotension (NTN). Urinary dysbiosis associated urinary tract and systemic diseases. However, the role of microbiome KSD complicated HTN remains unclear. Methods This study investigated relationship between pelvis blood pressure (BP) patients co-occurring (KSD-HTN) healthy controls (HC) by conducting 16S rRNA gene sequencing bacteria urine samples. The samples were collected (after...
Abstract Circular RNAs (circRNAs) have been demonstrated to play vital roles in cancer development and progression. However, studies on the association between circRNAs prostate (PCa) are still lacking. CircRNA sequencing of two pairs PCa tissues adjacent normal was conducted present study, qRT–PCR performed verify results. Functional experiments were investigate cellular functions after specific changes. Mass spectrometry analysis RNA pull-down Co-IP assays further conducted. Downstream...
Kidney fibrosis is accompanied by vascular dysfunction. Discovering new ways to ameliorate dysfunctional angiogenesis may bypass kidney fibrosis. YAP (Yes-associated protein) plays a multifaceted role during angiogenesis. Here, we found that selectively targeting signaling in the endothelium ameliorates unilateral ureteral obstruction (UUO)-induced Genetic deletion of Yap1, encoding protein, VE-cadherin+ endothelial cells inhibited endothelial-to-mesenchymal transition (EndMT) and improved...
A close relationship exists between castration-resistant prostate cancer (CRPC) and histidine metabolism by gut microbes. However, the effects of metabolite imidazole propionate (IMP) on (PCa) its underlying mechanisms are not well understood. We first assessed IMP cell proliferation migration at cellular level. Subsequently, we investigated mechanism action using transcriptome sequencing, qPCR, Western blot analysis. Finally, validated our findings in vivo a mouse model. Histidine had no...
The fourth Machine Learning for Health (ML4H) symposium was held in person on December 15th and 16th, 2024, the traditional, ancestral, unceded territories of Musqueam, Squamish, Tsleil-Waututh Nations Vancouver, British Columbia, Canada. included research roundtable sessions to foster discussions between participants senior researchers timely relevant topics ML4H community. organization roundtables at conference involved 13 27 junior chairs across tables. Each session an invited chair (with...
Background Bladder cancer (BLCA) is the most common malignancy of urinary system and one cancers worldwide. This study seeks to examine influence angiogenesis-related genes (ARGs) linked disulfidptosis on BLCA patients formulate a prognostic model for evaluating their prognosis response immunotherapy. Methods used sequencing data in Cancer Genome Atlas (TCGA) database. Unsupervised consensus clustering analysis, cox regression least absolute shrinkage selection operator (LASSO) analysis were...
Abstract Background The long-held notion that, without urinary tract or circulatory infection, bladder urine and blood are sterile biofluids has been disproven. There have no previous reports on the kidney pelvis microbiome after disinfection in stone patients. This study aimed to determine whether a is present eliminating influence of microbiome, composition different patients with (SKP) non-stone (NSKP), correlation between SKP patient clinical characteristics. Results Comparisons...
Abstract Circular RNAs (circRNAs) are novel biomarkers of various cancers. CircRNAs can sponge miRNAs and regulate target mRNAs, which was called competing endogenous (ceRNA). This study designed to identify circRNAs related patients with clear cell renal carcinoma (ccRCC) the first select three independent Gene Expression Omnibus microarrays covering circRNAs, miRNAs, mRNAs for multiple analyses. The data clinical cases applied in our were obtained from Cancer Genome Atlas. We successfully...
Retinoic acid receptor-related orphan receptor alpha (RORA) plays a key role in the regulation of lipid and glucose metabolism insulin expression that are implicated development type 2 diabetes mellitus (T2DM). However, effects genetic variants RORA gene on susceptibility to T2DM remain unknown. Nine tagging single-nucleotide polymorphisms (SNPs) were screened by using SNaPshot method 427 patients with 408 normal controls. Association between genotypes haplotypes derived from these SNPs was...
The recombinant strain Y. lipolytica XYL+ can utilize xylose to produce microbial lipids efficiently. However, its uptake is severely delayed in the presence of d-glucose. In this study, adaptive laboratory evolution (ALE) strains medium containing and d-glucose analogue 2-deoxyglucose (dG) performed. After four stages over a total 64 days, for first time, we obtained an (yl-XYL+*04*10) that cometabolize glucose, with diminished glucose repression. Xylose kinetics showed it could efficiently...
Background: Several types of extracellular vesicles (EVs) secreted by various immune and non-immune cells are present in the human plasma. We previously demonstrated that EV abundance microRNA content change pathological conditions, such as HIV infection. Here, we investigated daily variations large small EVs, terms contents people living with (PLWH) receiving antiretroviral therapy (HIV+ART) uninfected controls (HIV−). Methods: Venous blood samples from n = 10 HIV+ART HIV− participants were...
Abstract Disk-like domain receptor 1 (DDR1) is a crucial regulator of pro-inflammatory mediators and matrix-degrading enzymes. Although mounting evidence supports vital role for DDR1 in the tumorigenesis some cancers, no pan-cancer analysis has been reported. Therefore, we aimed to explore prognostic value 33 cancer types investigate its potential immune function. We used range bioinformatics approaches carcinogenic multiple cancers. found that was expressed at high levels most expression...