A5002954968- Corneal surgery and disorders
- Ocular Surface and Contact Lens
- Preterm Birth and Chorioamnionitis
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Pelvic floor disorders treatments
- Corneal Surgery and Treatments
- Pregnancy-related medical research
- Virus-based gene therapy research
- CAR-T cell therapy research
- Ferroptosis and cancer prognosis
- Nanoplatforms for cancer theranostics
- Ocular Oncology and Treatments
- ATP Synthase and ATPases Research
- Immunotherapy and Immune Responses
- Histone Deacetylase Inhibitors Research
- Pediatric Hepatobiliary Diseases and Treatments
- Mitochondrial Function and Pathology
- Protein Degradation and Inhibitors
- Cancer Research and Treatments
- Immune cells in cancer
- Hippo pathway signaling and YAP/TAZ
- Animal Virus Infections Studies
- RNA Interference and Gene Delivery
- Gallbladder and Bile Duct Disorders
Jiangnan University
2025
Southeast University
2009-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Eye & ENT Hospital of Fudan University
2021-2024
Shanghai Eye Disease Prevention & Treatment Center
2024
Sun Yat-sen University
2015-2023
Wuxi People's Hospital
2023
Nanjing Medical University
2020
Wuxi No.2 People's Hospital
2020
State Key Laboratory of Digital Medical Engineering
2009
Glioblastoma multiforme (GBM) is among the most aggressive of human cancers. Although differentiation therapy has been proposed as a potential approach to treat GBM, mechanisms induced remain poorly defined. Here, we established an model GBM using cAMP activators that specifically directed into astroglia. Transcriptomic and proteomic analyses revealed oxidative phosphorylation mitochondrial biogenesis are involved in GBM. Dibutyryl cyclic AMP (dbcAMP) reverses Warburg effect, evidenced by...
Abstract Differentiation therapy using small molecules is a promising strategy for improving the prognosis of glioblastoma (GBM). Histone acetylation plays an important role in cell fate determination. Nevertheless, whether histone specific sites determines GBM cells remains to be explored. Through screening from 349 molecule-library, we identified that deacetylase inhibitor (HDACi) MS-275 synergized with 8-CPT-cAMP was able transdifferentiate U87MG into neuron-like cells, which were...
Cancers figure among the leading causes of morbidity and mortality worldwide. The number new cases is expected to rise by about 70% over next 2 decades. Development novel therapeutic agents urgently needed for clinical cancer therapy. Alphavirus M1 a Getah-like virus isolated from China with genome positive single-strand RNA. We have previously identified that alphavirus naturally existing oncolytic significant anticancer activity against different kinds (e.g., liver cancer, bladder colon...
Abstract Dry eye disease (DED) is a growing public health concern affecting millions of people worldwide and causing ocular discomfort visual disturbance. Developing its therapeutic drugs based on animal models suffer from interspecies differences poor prediction human trials. Here, we established long‐term 3D corneal epithelial organoids, which recapitulated the cell lineages gene expression signature epithelium. Organoids can be regulated to differentiate ex vivo, but addition FGF10...
Background Bladder cancer (BLCA) is the most common malignancy of urinary system and one cancers worldwide. This study seeks to examine influence angiogenesis-related genes (ARGs) linked disulfidptosis on BLCA patients formulate a prognostic model for evaluating their prognosis response immunotherapy. Methods used sequencing data in Cancer Genome Atlas (TCGA) database. Unsupervised consensus clustering analysis, cox regression least absolute shrinkage selection operator (LASSO) analysis were...
Vacuum preloading with straw drainage has been used as an eco-friendly soil-reinforcement method to promote the consolidation of dredged sludge. In previous studies, degradation straw, essential factor influencing dredged-sludge consolidation, often disregarded. this study, laboratory tests were conducted investigate effects on efficiency The vacuum level within decreased increasing time, causing a reduction in water discharge and settlement. Consequently, moisture content increased shear...
Activation of the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) pathway induces glial differentiation glioblastoma (GBM) cells, but mechanism by which microRNA (miRNA) regulate this process remains poorly understood. In study, performing miRNA genomics and loss- gain-of-function assays in dibutyryl-cAMP-treated GBM we identified a critical negative regulator, hsa-miR-1275, that modulates set genes involved cancer progression, stem cell maintenance, maturation differentiation....
Oncolytic virotherapy is a novel and intriguing treatment strategy for cancer therapy. However, the clinical potential of oncolytic virus as single agent limited. M1 promising that has been tested in preclinical studies. In this study, we investigated effect combination use Bcl-2 family inhibitors. A chemical compounds screening including ten inhibitors demonstrated pan-Bcl-2 selectively augmented oncolysis cells at very low doses. The mechanism enhanced antitumor with mainly due to...
Laparoscopic cholecystectomy (LC) with laparoscopic common bile duct exploration (LCBDE) is convenient in treating cholelithiasis and choledocholithiasis due to its advantage of accelerated recovery. This retrospective study aimed summarize the experience treatment via three-port approach LCBDE Eastern China.Patients diagnosed between July 2019 October 2021 were included. Patients who received LC+LCBDE+primary suturing (CBD) a assigned LCBDE-P group, those LC+LCBDE+T-tube drainage CBD...
Abstract This study aimed to identify feature genes and explore the molecular mechanisms of keratoconus (KC). We downloaded data files from NCBI GEO public database. The Limma package was used for differential expression analysis gene profiles. Lasso regression genes. CIBERSORT algorithm infer proportion immune‐infiltrating cells analyse correlation between levels immune cells. Related transcription factors miRNAs key were predicted using Cistrome DB Mircode databases. Analysis differences...
Circular RNAs (circRNAs) are a novel class of endogenous noncoding that regulate gene expression through the competitive RNA (ceRNA) mechanism. CircRNA-associated-ceRNA networks closely related to oxidative stress-related diseases. Oxidative stress-induced dysfunction corneal endothelium (CE) is major pathological feature in many This study was aimed analyze circRNA-associated-ceRNA CE dysfunction.A model established using human endothelial cells (HCECs) treated with H 2 O at concentration...
Uveal melanoma (UM) is a highly metastatic cancer with resistance to immunotherapy. The present study aimed identify novel feature genes and molecular mechanisms in UM through analysis of single‑cell sequencing data. For this purpose, data were downloaded from Cancer Genome Atlas National Center for Biotechnology Information Gene Expression Omnibus public databases. statistical function the CellPhoneDB software package was used analyze ligand‑receptor relationships genes. Metascape database...