A5101911810- Neuroscience and Neuropharmacology Research
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Complement system in diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Venomous Animal Envenomation and Studies
- Organoselenium and organotellurium chemistry
- Mitochondrial Function and Pathology
- Monoclonal and Polyclonal Antibodies Research
- Renal Diseases and Glomerulopathies
- Receptor Mechanisms and Signaling
- interferon and immune responses
- Marine Sponges and Natural Products
- Mesenchymal stem cell research
- 3D Printing in Biomedical Research
- Ubiquitin and proteasome pathways
- Cancer Mechanisms and Therapy
- Nuclear Receptors and Signaling
- MicroRNA in disease regulation
- Marine Invertebrate Physiology and Ecology
- Atherosclerosis and Cardiovascular Diseases
- Neuroscience of respiration and sleep
- RNA Interference and Gene Delivery
- High Altitude and Hypoxia
- Eosinophilic Disorders and Syndromes
Sun Yat-sen University
2012-2024
Fudan University
2021
Pudong Medical Center
2021
Macau University of Science and Technology
2020
Shanghai Medical College of Fudan University
2020
Huashan Hospital
2020
WuXi AppTec (United States)
2018
Third Affiliated Hospital of Sun Yat-sen University
2015
University of Pennsylvania
2012-2014
Nanjing University
2006-2007
Hyperglycolysis, observed within the penumbra zone during brain ischemia, was shown to be detrimental for tissue survival because of lactate accumulation and reactive oxygen species overproduction in clinical experimental settings. Recently, mounting evidence suggests that glycolytic reprogramming induced metabolic enzymes can fuel activation peripheral immune cells. However, possible roles details regarding hyperglycolysis neuroinflammation ischemia are relatively poorly understood. Here,...
Abstract Snakes have numerous features distinctive from other tetrapods and a rich history of genome evolution that is still obscure. Here, we report the high-quality five-pacer viper, Deinagkistrodon acutus , comparative analyses with representative snake lizard genomes. We map evolutionary trajectories transposable elements (TEs), developmental genes sex chromosomes onto phylogeny. TEs exhibit dynamic lineage-specific expansion, many viper show brain-specific gene expression along their...
Cancer stem cells (CSCs) are a small subset of malignant cells, possessing stemness, with strong tumorigenic capability, conferring resistance to therapy and leading the relapse nasopharyngeal carcinoma (NPC). Our previous study suggested that cyclooxygenase-2 (COX-2) would be novel target for CSCs-like side population (SP) in NPC. In present study, we further found COX-2 maintained stemness NPC by enhancing activity mitochondrial dynamin-related protein 1 (Drp1), fission mediator, studying...
Abstract Background Dysregulated activation of the inflammasome is involved in various human diseases including acute cerebral ischemia, multiple sclerosis and sepsis. Though many inhibitors targeting NOD-like receptor protein 3 (NLRP3) have been designed developed, none are clinically available. Growing evidence suggests that apoptosis-associated speck-like containing a CARD (ASC), oligomerization which key event for assembly inflammasome, may be another promising therapeutic strategy....
Abstract Background The snake venom gland is a specialized organ, which synthesizes and secretes the complex abundant toxin proteins. Though gene expression in has been extensively studied, focus on components of venom. As far as molecular mechanism secretion metabolism concerned, we still knew little. Therefore, fundamental question being arisen what genes are expressed glands besides many components? Results To examine transcripts Deinagkistrodon acutus unveil potential its products...
Cancers figure among the leading causes of morbidity and mortality worldwide. The number new cases is expected to rise by about 70% over next 2 decades. Development novel therapeutic agents urgently needed for clinical cancer therapy. Alphavirus M1 a Getah-like virus isolated from China with genome positive single-strand RNA. We have previously identified that alphavirus naturally existing oncolytic significant anticancer activity against different kinds (e.g., liver cancer, bladder colon...
Abstract It has been demonstrated that trimethylamine N-oxide (TMAO) serves as a driver of atherosclerosis, suggesting reduction TMAO level might be potent method to prevent the progression atherosclerosis. Herein, we explored role in stability carotid atherosclerotic plaques and disclosed underlying mechanisms. The unstable artery plaque models were established C57/BL6 mice. L-carnitine (LCA) methimazole (MMI) administration applied increase reduce levels. Hematoxylin eosin (H&E)...
Leonurine (LEO) is a bioactive small molecular compound that has protective effects on the cardiovascular system and prevents early progression of atherosclerosis; however, it not clear whether LEO effective for plaque stability. A novel mouse atherosclerosis model involving tandem stenosis (TS) right carotid artery combined with western diet (WD) feeding was used. Apolipoprotein E gene–deficient mice were fed WD received administration daily 13 weeks. TS introduced 6 weeks after onset...
Intracerebral hemorrhage (ICH) represents the most severe subtype of stroke, and lack effective clinical pharmacotherapies poses a substantial threat to human health. Hematoma plays crucial role in determining prognosis ICH patients by causing primary mechanical extrusion, followed secondary brain injuries, such as cerebral edema, iron-mediated oxidative stress, inflammation resulting from its degradation products. 5α-androst-3β,5α,6β-triol (TRIOL) is neuroprotective steroid currently...
Aims and background To identify partially characterize the side population cells derived from three human pancreatic adenocarcinoma cell lines. Methods Side were sorted lines SW1990, Capan-2, BxPC-3 using flow cytometry then analyzed for proliferation, clone formation, differentiation, chemoresistance, invasive potential, tumorigenicity in a mouse model. Results Human carcinoma contain 2.7% ±0.35%, 3.6%± 1.2%, 2.8%± 0.8% cells, respectively. We further investigated cancer stem...
Hypobaric hypoxia (HH) exposure can cause serious brain injury as well life-threatening cerebral edema in severe cases. Previous studies on the mechanisms of HH-induced have been conducted primarily using non-primate animal models that are genetically distant to humans, thus hindering development disease treatment. Here, we report cynomolgus monkeys (<i>Macaca</i> <i>fascicularis</i>) exposed acute HH developed human-like syndrome involving and abnormal behavior. Transcriptome profiling...
Malignant glioma is the most lethal primary tumor of central nervous system, with notable cell invasion causing significant recurrence. Suppression very important for improving clinical outcomes. Drugs that directly disrupt cytoskeleton have been developed this purpose; however, drug resistance and unsatisfactory selectivity limited their use. Previously, we reported protein kinase A (PKA, also known as cyclic-AMP dependent kinase) activation induced differentiation cells.We used several...
Abstract Malignant gliomas are the most common and lethal intracranial tumors, differentiation therapy shows great potential to be a promising candidate for their treatment. Here, we have elaborated that PKA activator, forskolin, represses cell growth via cycle arrest in G0/G1 phase induces characteristic with elongated processes restoration of GFAP expression. In mechanisms, verified forskolin significantly diminishes mRNA protein level key regulator cyclin D1, maintenance low D1 expression...
Ischemic stroke is a leading cause of death worldwide, yet therapies are limited. During periods ischemia following reperfusion in ischemic stroke, not only loss energy supply, but few other factors including mitochondrial dysfunction and oxidative stress also make vital contribution to neuronal injury. Here we synthesized steroid compound 5α-androst-3β,5,6β-triol by 3 steps starting from dehydroepiandrosterone examined its effect on function primary cultured cortical neurons exposed hypoxia...
Mycoplasma infection has been reported to be associated with cancer migration, invasion, epithelial-mesenchymal transition as well the resistance nucleoside analogues chemotherapeutic drugs. In this study, we found that sensitivity of hepatocarcinoma cells Cisplatin, Gemcitabine and Mitoxantrone was increased by mycoplasma elimination. Similar effect anti-mycoplasma agent, interrupting interaction between hyorhinis membrane protein P37 Annexin A2 host using N-terminal ANXA2 polypeptide...
Chiral organoselenium compounds can be attained from three types of asymmetric synthesis. substratecontrolled methods, chiral auxiliary-controlled and catalyst-controlled methods toward optically active derivatives were illustrated. The strategy classification underlying all synthesis therefore involve enantiomerically pure to influence the stereochemical outcome reactions. In this review, advances in some important classes described. Keywords: Prochiral Olefin, Selenocyclization,...