A5066632653- Gallbladder and Bile Duct Disorders
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Vascular Malformations and Hemangiomas
- Chemokine receptors and signaling
- Sarcoma Diagnosis and Treatment
- Cardiac tumors and thrombi
- Pancreatic and Hepatic Oncology Research
- Inflammatory Biomarkers in Disease Prognosis
- Cytokine Signaling Pathways and Interactions
- Biliary and Gastrointestinal Fistulas
- Barrier Structure and Function Studies
- Inflammasome and immune disorders
- RNA modifications and cancer
- Muscle activation and electromyography studies
- Spinal Cord Injury Research
- Macrophage Migration Inhibitory Factor
- Transcranial Magnetic Stimulation Studies
- Zebrafish Biomedical Research Applications
- Retinal Diseases and Treatments
- Abdominal vascular conditions and treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Adenosine and Purinergic Signaling
Sun Yat-sen University
2017-2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2024
Hebei General Hospital
2020-2022
Hyperglycolysis, observed within the penumbra zone during brain ischemia, was shown to be detrimental for tissue survival because of lactate accumulation and reactive oxygen species overproduction in clinical experimental settings. Recently, mounting evidence suggests that glycolytic reprogramming induced metabolic enzymes can fuel activation peripheral immune cells. However, possible roles details regarding hyperglycolysis neuroinflammation ischemia are relatively poorly understood. Here,...
Abstract Background Dysregulated activation of the inflammasome is involved in various human diseases including acute cerebral ischemia, multiple sclerosis and sepsis. Though many inhibitors targeting NOD-like receptor protein 3 (NLRP3) have been designed developed, none are clinically available. Growing evidence suggests that apoptosis-associated speck-like containing a CARD (ASC), oligomerization which key event for assembly inflammasome, may be another promising therapeutic strategy....
Abstract The impairment of the blood-brain barrier (BBB) has been increasingly recognised as a critical element in early pathogenesis Alzheimer’s disease (AD), prompting focus on brain endothelial cells (BECs), which serve primary constituents BBB. Death receptor 6 (DR6) is highly expressed vasculature and acts downstream Wnt/β-catenin pathway to promote BBB formation during development. Here, we found that DR6 levels were significantly reduced murine model AD (APP swe /PS1 dE9 mice) at...
Abstract Given that glioma stem cells (GSCs) play a critical role in the initiation and chemoresistance glioblastoma multiforme (GBM), targeting GSCs is an attractive strategy to treat GBM. Utilizing anti-cancer compound library, we identified R406, active metabolite of FDA-approved Syk inhibitor for immune thrombocytopenia (ITP), with remarkable cytotoxicity against but not normal neural cells. R406 significantly inhibited neurosphere formation triggered apoptosis GSCs. induced metabolic...
Intracerebral hemorrhage (ICH) represents the most severe subtype of stroke, and lack effective clinical pharmacotherapies poses a substantial threat to human health. Hematoma plays crucial role in determining prognosis ICH patients by causing primary mechanical extrusion, followed secondary brain injuries, such as cerebral edema, iron-mediated oxidative stress, inflammation resulting from its degradation products. 5α-androst-3β,5α,6β-triol (TRIOL) is neuroprotective steroid currently...
Abstract Background Under physiological conditions, CXCL12 modulates cell proliferation, survival, angiogenesis, and migration mainly through CXCR4. Interestingly, the newly discovered receptor CXCR7 for is highly expressed in many tumor cells as well tumor-associated blood vessels, although level of normal low. Recently, studies have suggested that promotes growth metastasis more than 20 human malignancies, among which lung cancer leading cause cancer-associated deaths worldwide. Thus,...
Activation of the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) pathway induces glial differentiation glioblastoma (GBM) cells, but mechanism by which microRNA (miRNA) regulate this process remains poorly understood. In study, performing miRNA genomics and loss- gain-of-function assays in dibutyryl-cAMP-treated GBM we identified a critical negative regulator, hsa-miR-1275, that modulates set genes involved cancer progression, stem cell maintenance, maturation differentiation....
Following a spinal cord injury, there are usually number of neural pathways that remain intact in the cord. These residual nerve fibers important, as they could be used to reconstruct circuits enable motor function. Our group previously designed novel magnetic stimulation protocol, targeting cortex and roots, led significant improvements locomotor function patients with chronic incomplete injury. Here, we investigated how root contributes improved using rat model Rats underwent surgery clamp...
Neuroinflammation has been well recognized as a key pathological event in acute glaucoma. The medical therapy of glaucoma mainly focuses on lowering intraocular pressure (IOP), while there are still scarce anti-inflammatory agents the clinical treatment Here we reported that β,3α,5α-trihydroxy-androst-6-one (sterone), novel synthetic polyhydric steroid, blocked neuroinflammation mediated by microglia/macrophages and alleviated loss retinal ganglion cells (RGCs) caused hypertension (AIH)....
As one of the key injury incidents, tissue acidosis in brain occurs very quickly within several minutes upon onset ischemic stroke. Glutamate, an excitatory amino acid inducing neuronal excitotoxicity, has been reported to trigger decrease intracellular pH (pHi) via modulating proton-related membrane transporters. However, there remains a lack clarity on possible role glutamate regulating metabolism. Here, we show that 200 μM treatment promotes glycolysis and inhibits mitochondrial oxidative...
Nuclear receptor subfamily 4 group A member 3 (NR4A3) protects the vascular endothelial cell (VEC) against hypoxia stress, whose expression is primarily reported to be governed at a transcriptional level. However, regulation of NR4A3 in protein level largely unknown. Here, we report that abundance decreased immensely VEC injury induced by reoxygenation after oxygen-glucose deprivation (OGD-R), which significantly blocked administration antioxidative steroid TRIOL. Moreover, notable...
Acute cholecystitis is a common clinical inflammatory lesion of the gallbladder. With aggravation inflammation, ischemic, necrosis, and even acute gangrenous occur in At same time, variety complications appear, seriously affecting prognosis patients. It recommended that ultrasound can be utilized as first choice for diagnosis cholecystitis, due to its fastness, convenience, non-radiation, low cost. Here, we summarize latest progress predict ultrasound, thus assisting us identifying patients...
Abstract Background Primary undifferentiated pleomorphic sarcoma (UPS) of the pancreas is an exceedingly rare malignant tumor, with only 15 cases have been reported in medical literature. At present, clinicians poor recognition epidemiology, diagnosis and treatment this disease yet not established. Case presentation In report, we depict clinical imaging characteristics a 37-year-old man presenting primarily cystic UPS. The patient complained epigastric pain distention over 20 days. Abdominal...