A5100323011- Genomics, phytochemicals, and oxidative stress
- Hearing, Cochlea, Tinnitus, Genetics
- Endoplasmic Reticulum Stress and Disease
- Ion Channels and Receptors
- Inflammatory mediators and NSAID effects
- Barrier Structure and Function Studies
- RNA modifications and cancer
- Cancer-related gene regulation
- Geological and Geochemical Analysis
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Vestibular and auditory disorders
- Ion channel regulation and function
- Liver Disease Diagnosis and Treatment
- Phagocytosis and Immune Regulation
- Cancer Immunotherapy and Biomarkers
- Phytochemicals and Antioxidant Activities
- Cardiac Ischemia and Reperfusion
- Molecular Sensors and Ion Detection
- Signaling Pathways in Disease
- Plant Disease Resistance and Genetics
- Bone Metabolism and Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Circular RNAs in diseases
- Ear Surgery and Otitis Media
Fudan University
2023-2025
Shanghai Institute of Applied Physics
2024-2025
Chinese Academy of Sciences
2024-2025
University of Chinese Academy of Sciences
2024-2025
Dalian Medical University
2025
Anhui Medical University
2013-2024
Peking University
2019-2024
Nankai University
2024
Zhongshan Hospital
2024
Xiangya Hospital Central South University
2024
The paucity of selective agonists for TWIK-related acid-sensitive K+ 3 (TASK-3) channel, a member two-pore domain (K2P) channels, has contributed to our limited understanding its biological functions. By targeting druggable transmembrane cavity using structure-based drug design approach, we discovered biguanide compound, CHET3, as highly allosteric activator TASK-3-containing K2P including TASK-3 homomers and TASK-3/TASK-1 heteromers. CHET3 displayed potent analgesic effects in vivo variety...
Oxidative stress and autophagy play essential roles in the development of senile osteoporosis which is characterized by disrupted osteoclastic bone resorption osteoblastic formation. Orcinol glucoside (OG), a phenolic glycoside isolated from Curculigo orchioides Gaertn, possesses antiosteoporotic properties. This study examined protective effects OG on loss SAMP6 mice explored underlying mechanisms. The osteoporotic were treated with oral administration. RAW264.7 cells induced to...
Abstract Circular RNAs (circRNAs) have been demonstrated to play vital roles in cancer development and progression. However, studies on the association between circRNAs prostate (PCa) are still lacking. CircRNA sequencing of two pairs PCa tissues adjacent normal was conducted present study, qRT–PCR performed verify results. Functional experiments were investigate cellular functions after specific changes. Mass spectrometry analysis RNA pull-down Co-IP assays further conducted. Downstream...
The elderly population is at risk of osteoarthritis (OA), a common, multifactorial, degenerative joint disease. Environmental, genetic, and epigenetic (such as DNA hydroxymethylation) factors may be involved in the etiology, development, pathogenesis OA. Here, comprehensive bioinformatic analyses were used to identify aberrantly hydroxymethylated differentially expressed genes pathways determine underlying molecular mechanisms susceptibility-related for inheritance.Gene expression microarray...
Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer, accounting for 80-90% of cases. Mutations are commonly found in signaling regulating PI3K/Akt pathway, leading to oncogenic cell proliferation and survival. Key transcription factors that negatively regulated downstream members forkhead box O family (FOXO). FOXOs were initially considered as tumor suppressors by inducing cycle arrest apoptosis. However, there increasing evidence showing FOXOs, especially FOXO3, can...
The unique physiochemical properties of nanomaterials have been widely used in drug delivery systems and diagnostic contrast agents. safety issues biomaterials with exceptional biocompatibility hemo-compatibility also received extensive attention at the nanoscale, especially cardiovascular disease. Therefore, we conducted a study effects poly (lactic-co-glycolic acid) nanoparticles (PLGA NPs) on development aortic atherosclerotic plaques ApoE-/- mice. particle size PLGA NPs was 92.69 ± 3.1...
Abstract Hereditary hearing loss is genetically heterogeneous, with diverse clinical manifestations. Here we performed targeted genome sequencing of 227 related genes in 1027 patients bilateral and 520 healthy volunteers normal to comprehensively identify the molecular etiology hereditary a large cohort from China. We obtained diagnostic rate 57.25% (588/1027) for patients, while 4.67% (48/1027) were identified uncertain diagnoses. Of implicated 35 genes, three common including SLC26A4...
Nowadays, small-molecule drugs have become an indispensable part of tumor immunotherapy. Accumulating evidence has indicated that specifically blocking PGE2/EP4 signaling to induce robust antitumor immune response represents attractive immunotherapy strategy. Herein, a 2H-indazole-3-carboxamide containing compound 1 was identified as EP4 antagonist hit by screening our in-house library. Systematic structure–activity relationship exploration leads the discovery 14, which displayed...
DNA damage signals transducer RING finger protein 8 (RNF8) is involved in maintaining genomic stability by facilitating the repair of double-strand breaks (DSB) via ubiquitin signaling. By analyzing TCGA database and colon cancer tissue microarrays, we found that expression level RNF8 was positively correlated with c-Myc cancer, which were closely associated poor survival patients. Furthermore, overexpressing knocking down increased decreased cells, respectively. In addition, interacted...
The present study aimed to investigate the potential molecular mechanisms by which galectin‑1 (Gal‑1) and glucose‑regulated protein 78 (GRP78) influence development of malignant gastric cancer (GC). Immunohistochemistry western blotting were used map expression location Gal‑1 gene in 80 paraffin‑embedded GC samples, 16 fresh samples surrounding tissues. was overexpressed knocked down using lentiviral vectors human cell lines HGC‑27 AGS. Through use Cell Counting Kit‑8 assay, clone formation...
: Liver hepatocellular carcinoma (LIHC) is one of the leading causes cancer-related death. The prognostic outcomes advanced LIHC patients are poor. Hence, reliable biomarkers for urgently needed.
Estrogen and progesterone specify the establishment of uterine receptivity mainly through their respective nuclear receptors, ER PR. PR is transcriptionally induced by estrogen-ER signaling in endometrium, but how protein homeostasis endometrium regulated remains elusive. Here, we demonstrated that uterine-selective depletion P38α derails normal ascribed to dramatic down-regulation disordered responsiveness stromal compartment, leading defective implantation female infertility. Specifically,...
ABSTRACT Objective To investigate the cellular components and immunological characteristics of head neck rhabdomyosarcoma (RMS) microenvironment. Methods We conducted single‐cell transcriptomics to analyze RMS CellChat was utilized for analyzing intercellular interactions. The cancer genome atlas database used validation. CIBERSORT applied immune infiltration profiling. Functional enrichment analyses were performed using Kyoto Encyclopedia Genes Genomes. Gene set scores calculated...
<title>Abstract</title> Background Epigenetics modification has emerged as a potential mechanism of action for MAFLD. The histone methylase SUV39H1 is key epigenetic transcription factor that regulates adipogenesis and inflammation, but its role in MAFLD progression remains largely unknown. Methods In this study, the high fat diet (HFD) induced mice palmitic acid (PA) primary mouse hepatocytes were adopted to investigate effects mechanisms on Point mutation knockdown SET domain PA-stimulated...
<title>Abstract</title> The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish work to be cited a reference. Questions should directed corresponding author.
Radiopharmaceuticals are a promising therapeutic strategy for tumors with less reduced resistance and minimal side effects. In our previous study, we radiolabeled the monoclonal antibody zolbetuximab, which targets CLDN18.2, 125I, labeled compound showed favorable tumor targeting retention. this research article, [131I]I-zolbetuximab was prepared to investigate its effect on gastric cancer using in vitro vivo studies. The zolbetuximab 131I Iodogen method. uptake mechanism of investigated...
Phospholipid scramblase 1 (PLSCR1), a lipid-binding and Ca2+-sensitive protein located on plasma membranes, is critically involved in phosphatidylserine (PS) externalization, an important process cell apoptosis. Transient receptor potential canonical 5 (TRPC5), nonselective Ca2+ channel neurons that interacts with many downstream molecules, participating diverse physiological functions including temperature or mechanical sensation. The interaction between TRPC5 PLSCR1 has never been...
Abstract Background Clear cell renal carcinoma (ccRCC) is one of the most prevalent malignant diseases in urinary system with more than 140,000 related deaths annually. Ubiquitination–deubiquitination homeostasis an important factor ccRCC progression; ubiquitin‐specific peptidase 53 (USP53) belongs to family deubiquitinating enzymes, but its functions are rarely reported. Methods Databases obtained from GEO and TCGA were analyzed reveal role USP53 ccRCC. CCK‐8/BrdU EDU assays used detect...