A5056783314- Liver Disease Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Osteoarthritis Treatment and Mechanisms
- Pancreatic and Hepatic Oncology Research
- Collagen: Extraction and Characterization
- Liver physiology and pathology
- Ocular Infections and Treatments
- Proteoglycans and glycosaminoglycans research
- Pancreatitis Pathology and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Organ Transplantation Techniques and Outcomes
- Intraocular Surgery and Lenses
- Hepatocellular Carcinoma Treatment and Prognosis
- Telomeres, Telomerase, and Senescence
- Bone Tissue Engineering Materials
- Protease and Inhibitor Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Ocular Surface and Contact Lens
- Immune Cell Function and Interaction
- Bone and Dental Protein Studies
- Connective tissue disorders research
- Chromatin Remodeling and Cancer
- Gallbladder and Bile Duct Disorders
- Neuroendocrine Tumor Research Advances
- Liver Disease and Transplantation
Klinikum rechts der Isar
2016-2025
Technical University of Munich
2016-2025
Universitätsklinikum Tübingen
2025
University of Tübingen
2024-2025
Munich University of Applied Sciences
2023
München Klinik
2021-2023
Yale University
2022
Caritas-Krankenhaus St. Josef
2020
Klinikum Region Hannover
2020
Goethe University Frankfurt
2013-2019
Checkpoints that limit stem cell self-renewal in response to DNA damage can contribute cancer protection but may also promote tissue aging. Molecular components control responses remain be delineated. Using vivo RNAi screens, we identified basic leucine zipper transcription factor, ATF-like (BATF) as a major component limiting of hematopoietic cells (HSCs) telomere dysfunction and γ-irradiation. induces BATF G-CSF/STAT3-dependent manner resulting lymphoid differentiation HSCs. deletion...
<h3>Importance</h3> Telomeres protect DNA from damage. Because they shorten with each mitotic cycle, leukocyte telomere length (LTL) serves as a clock. Reduced LTL has been associated multiple human disorders. <h3>Objective</h3> To determine the association between and overall well disease-specific mortality morbidity. <h3>Design, Setting, Participants</h3> This multicenter, community-based cohort study conducted March 2006 to December 2010 included longitudinal follow-up (mean [SD], 12 [2]...
Abstract Telomere shortening impairs liver regeneration in mice and is associated with cirrhosis formation humans chronic disease. In humans, telomerase mutations have been familial diseases leading to bone marrow failure or lung fibrosis. It currently unknown whether associate induced by The RNA component (TERC) the reverse transcriptase (TERT) were sequenced 1,121 individuals (521 patients disease 600 noncirrhosis controls). length was analyzed carrying gene mutations. Functional defects...
Alternatively polarized macrophages (Mϕ) shape the microenvironment of hepatocellular carcinoma (HCC) and temper anticancer immune responses. We investigated if sorafenib alters HCC by restoring classical macrophage polarization triggering tumor-directed natural killer (NK) cell In vivo experiments were conducted with (25 mg/kg)-treated C57BL/6 wildtype as well hepatitis B virus (HBV) lymphotoxin transgenic mice without HCC. Monocyte-derived Mϕ or tumor-associated (TAM) isolated from tissue...
Section of the anterior cruciate ligament has been performed in knee 11 mature dogs. The macroscopically normal cartilage from patella and femoral trochlea animals killed 2 to 32 weeks after operation was used for histological, histomorphometrical, biochemical analysis. Previously undescribed degenerative lesions superficial matrix were observed, there evidence secondary healing these lesions. An early progressive decrease cell density a later increase thickness without any change middle...
Early detection is the only promising approach to significantly improve survival of patients with pancreatic cancer (PCa). Noninvasive tools for diagnosis, prognosis, and monitoring this disease are urgent need. The purpose study was identify validate new biomarkers in PCa patient serum samples.Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry has been applied analyze protein alterations associated sets potential indicative disease. A cohort 96 samples from...
Angiocrine signaling by liver sinusoidal endothelial cells (LSECs) regulates hepatic functions such as growth, metabolic maturation, and regeneration. Recently, we identified GATA4 the master regulator of LSEC specification during development. Herein, studied role in adult pathogenesis.We generated Clec4g-icretg/0xGata4fl/fl (Gata4LSEC-KO) mice with LSEC-specific depletion Gata4. Livers were analyzed histology, electron microscopy, immunohistochemistry/immunofluorescence, situ hybridization,...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is associated with accumulation of particular oncogenic mutations and recent genetic sequencing studies have identified ataxia telangiectasia-mutated (ATM) in PDAC cohorts. Here we report that conditional deletion ATM a mouse model induces greater number proliferative precursor lesions coupled pronounced fibrotic reaction. ATM-targeted mice display altered TGFβ-superfamily signalling enhanced epithelial-to-mesenchymal transition (EMT)...
In order to assess inflammatory features related severe asthma as compared with mild asthma, we investigated the secretion of 92 kDa gelatinase matrix metalloproteinase (MMP-9) in bronchial lavages six patients undergoing mechanical ventilation (MV) for status asthmaticus (SA) and asthma. Ten healthy nonventilated four under MV without preexisting respiratory disease were also investigated. Patients SA characterized by prominent neutrophilic inflammation (82 ± 4% versus 10% asthma). On basis...
Einleitung: Die Kapselendoskopie ist eine neue Methode, die nicht invasive diagnostische Endoskopie des gesamten Dünndarms ermöglicht. In dieser Studie untersuchten wir prospektiv Genauigkeit der im Vergleich zur Push-Enteroskopie bei Patienten mit obskurer gastrointestinaler Blutung. Methodik: Zwischen Juli 2001 und Oktober 2002 48 vermuteter Dünndarmerkrankung Kapselendoskopie. 33 Blutung (19 Männer, 14 Frauen, mittleres Alter 58 ± 23 Jahre) unauffälliger bidirektionaler wurden untersucht....
Herausgeber der Leitlinie ist die Sektion Endoskopie im Auftrag Deutschen Gesellschaft für Verdauungs- und Stoffwechselerkrankungen e. V. (DGVS), auch federführende Fachgesellschaft ist. Mitherausgeber sind an Leitlinienentwicklung beteiligten Fachgesellschaften Organisationen:
In postmenopausal osteoporosis, an impairment in enzymatic cross-links (ECL) occurs, leading part to a decline bone biomechanical properties. Biochemical methods by high performance liquid chromatography (HPLC) are currently used measure ECL. Another method has been proposed, Fourier Transform InfraRed Imaging (FTIRI), mature PYD/immature DHLNL ratio, using the 1660/1690 cm(-1) area ratio amide I band. However, bone, band composition is complex (collagens, non-collagenous proteins, water...