A5025980857- Bariatric Surgery and Outcomes
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Body Contouring and Surgery
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac, Anesthesia and Surgical Outcomes
- MicroRNA in disease regulation
- Gastroesophageal reflux and treatments
- Metastasis and carcinoma case studies
- Thermal Regulation in Medicine
- Metabolism, Diabetes, and Cancer
- Trauma and Emergency Care Studies
- Cancer Genomics and Diagnostics
- Colorectal Cancer Surgical Treatments
- Diabetes Treatment and Management
- Cardiovascular Disease and Adiposity
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Gallbladder and Bile Duct Disorders
- Surgical Simulation and Training
- Gastrointestinal Tumor Research and Treatment
University of Basel
2024-2025
University Hospital of Basel
2023-2025
Digestive Health Research Institute
2025
Heidelberg University
2015-2024
University Hospital Heidelberg
2016-2024
St. Claraspital
2023-2024
National Confidential Enquiry into Patient Outcome and Death
2023
University of Louisville
2011-2021
Chirurgische Universitätsklinik Heidelberg
2019-2020
University Hospital Schleswig-Holstein
2020
Abstract Hepatocellular carcinoma (HCC) can have viral or non-viral causes 1–5 . Non-alcoholic steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved for treating HCC, but biomarker-based stratification patients optimal response to therapy unmet need 6,7 Here we report the progressive accumulation exhausted, unconventionally activated CD8 + PD1 T cells in NASH-affected livers. In preclinical models NASH-induced therapeutic immunotherapy targeted at programmed...
The role and molecular mechanisms of intermittent fasting (IF) in non-alcoholic steatohepatitis (NASH) its transition to hepatocellular carcinoma (HCC) are unknown. Here, we identified that an IF 5:2 regimen prevents NASH development as well ameliorates established fibrosis without affecting total calorie intake. Furthermore, the blunted NASH-HCC when applied therapeutically. timing, length, number cycles type diet were critical parameters determining benefits fasting. Combined proteome,...
In Brief Objective: The main objective of this study was to investigate the potential use circulating microRNAs (miRNAs) as biomarkers colorectal (CR) adenomas. Background: Detection precancerous lesions such CR adenoma is a key reduce cancer (CRC) mortality. There great need for accurate, noninvasive detection and CRC. MiRNAs are non-protein-coding RNAs that regulate gene expression. Our prior work investigated dysregulation 5 plasma miRNAs in CRC patients. As intended, we undertook more...
We investigated whether hyperfibrinolysis and its severity was associated with outcome of traumatized nontraumatized patients.From April 2008 to 2010, all emergency patients were enrolled in this study. Hyperfibrinolysis divided into (trauma group) (nontrauma group). The trauma group matched 24 polytrauma without (matched Data from rotational thromboelastometry measurements, blood gas analysis (metabolic state), laboratory analysis, injury score, 30-day mortality collected.Thirty-five...
<b><i>Background:</i></b> Obesity surgery has proven successful for weight loss and the resolution of comorbidities. There is, however, little evidence on its success risk complications when considering age onset obesity (AOO), years (YOO), preoperative body mass index (BMI), Edmonton staging system (EOSS) score, as possible predictors loss, comorbidities, complications. <b><i>Methods:</i></b> Patients who underwent Roux-en-Y gastric bypass...
Objective: The aim was to analyze the learning curves of minimal invasive liver surgery(MILS) and propose a standardized reporting. Summary Background Data: MILS offers benefits compared open resections. For safe introduction along curve, formal training is recommended. However, definitions methods assess it lack standardization. Methods: A systematic review PubMed, Web Science, CENTRAL databases identified studies on in MILS. primary outcome number needed overcome curve. Secondary outcomes...
Morbid obesity and its consequences are considered risk factors for adverse outcome in trauma, although the pathophysiologic mechanisms incompletely understood. The aim of this study was to compare initial resuscitation, treatment, short-term severely injured patients by body mass index (BMI).A total 1,084 with an injury severity score 16 or greater were enrolled between 1996 2009 grouped according BMI. Their course treatment in-hospital analyzed univariate multivariate comparison.Of these...
Transient inflammation in adipose tissue triggers Jak-TGFβ signaling to promote beige adipocyte differentiation.
Chronic liver disease is a growing epidemic, leading to fibrosis and cirrhosis. TGF-β the pivotal profibrogenic cytokine that activates HSC, yet other molecules can modulate signaling during fibrosis. Expression of axon guidance semaphorins (SEMAs), which signal through plexins neuropilins (NRPs), have been associated with in HBV-induced chronic hepatitis. This study aims at determining their function regulation HSCs.
Therapeutic hypothermia is commonly used to improve neurological outcomes in patients after cardiac arrest. However, therapeutic increases sepsis risk and unintentional surgical infectious complications. Nonetheless, the molecular mechanisms by which dysregulates innate immunity are incompletely understood. We found that exposure of human monocytes cold (32°C) potentiated LPS-induced production TNF IL-6, while blunting IL-10 production. This dysregulation was associated with increased...