A5101688100- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Sirtuins and Resveratrol in Medicine
- Cardiovascular Disease and Adiposity
- Alcohol Consumption and Health Effects
- Exercise and Physiological Responses
- Cancer-related molecular mechanisms research
- Phytochemicals and Antioxidant Activities
- Immune Cell Function and Interaction
- Nuts composition and effects
- FOXO transcription factor regulation
- Autophagy in Disease and Therapy
- Childhood Cancer Survivors' Quality of Life
- Glutathione Transferases and Polymorphisms
- Immune Response and Inflammation
- Fibroblast Growth Factor Research
- Polyomavirus and related diseases
- Aldose Reductase and Taurine
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Natural Products and Biological Research
- Ubiquitin and proteasome pathways
- Nerve injury and regeneration
- Sulfur Compounds in Biology
- Chemokine receptors and signaling
Seoul National University
2018-2020
Yonsei University
2015-2020
Wayne State University
2013-2014
Catholic University of Korea
2012
Abstract The tumour microenvironment is a key regulators of progression through the secretion growth factors that activate epithelial-mesenchymal transition (EMT). Induction EMT step for from benign state to metastatic tumour. Adipose tissue forms bulk portion breast cancer microenvironment, emerging evidence indicates potential adipocytes influence adipokines can induce EMT. molecular mechanisms underlying how enhance largely unknown. We hypothesized paracrine signalling by and results in...
The higher prevalence of obesity-related metabolic disease in males suggests that female sex hormones provide protective mechanisms against the pathogenesis syndrome. Because browning white adipose tissue (WAT) is disease, we examined differences β3-adrenergic remodeling WAT mice.Effects receptor agonist CL316,243 (CL) on were investigated male and C57BL mice. role ovarian female-specific was studied control mice with failure induced by 4-vinylcyclohexene diepoxide treatment for 15 days.We...
Our previous study suggested that licorice has anti-inflammatory activity in lipopolysaccharide-stimulated microglial cells and anti-oxidative tert-butyl hydroperoxide-induced oxidative liver damage. In this study, we evaluated the effect of on chronic alcohol-induced fatty injury mediated by inflammation stress.Raw was extracted, quantitative qualitative analysis its components performed using LC-MS/MS. Mice were fed a liquid alcohol diet with or without for 4 weeks.We have standardized 70%...
De novo brown adipogenesis involves the proliferation and differentiation of progenitors, yet mechanisms that guide these events in vivo are poorly understood. We previously demonstrated treatment with a β3-adrenergic receptor (ADRB3) agonist triggers brown/beige gonadal white adipose tissue following adipocyte death clearance by macrophages. The close physical relationship between progenitors macrophages suggested clear dying adipocytes might generate proadipogenic factors. Flow cytometric...
Abstract Sustained β3 adrenergic receptor (ADRB3) activation simultaneously upregulates fatty acid synthesis and oxidation in mouse brown, beige, white adipose tissues; however, the cellular basis of this dual regulation is not known. Treatment mice with ADRB3 agonist CL316,243 (CL) increased expression synthase (FASN) medium chain acyl-CoA dehydrogenase (MCAD) protein within same cells classic brown tissues. Surprisingly, inguinal tissue, CL-upregulated FASN MCAD distinct cell populations:...
AMP-activated protein kinase (AMPK) plays a key role in controlling energy metabolism response to physiological and nutritional status. Although AMPK activation has been proposed as promising molecular target for treating obesity its related comorbidities, the use of pharmacological activators met with contradictory therapeutic challenges. Here we show regulatory mechanism through ubiquitination degradation by E3 ubiquitin ligase makorin ring finger 1 (MKRN1). MKRN1 depletion promotes...
The microenvironment of breast cancer comprises predominantly adipocytes. Adipocytes drive progression through the secretion adipocytokines. induce epithelial mesenchymal transition cells paracrine IL-6/Stat3 signalling. Treatment approaches that can target adipocytes in and abrogate signals growth metastasis are urgently needed. Repositioning old drugs has become an effective approach for discovering new drugs. In this study, niclosamide, FDA approved anthelminthic drug was evaluated its...
We investigated the role of connexin 43 (Cx43) in maintaining integrity mitochondria brown adipose tissue (BAT). The functional effects Cx43 were evaluated using inducible, adipocyte-specific knockout mice (Gja1 adipoq KO) and by overexpression knockdown cultured adipocytes. Mitochondrial morphology was electron microscopy mitochondrial function autophagy assessed immunoblotting, immunohistochemistry, qPCR. metabolic during cold stress following high fat diet feeding. expression higher BAT...
It has been reported that barley leaves possess beneficial properties such as antioxidant, hypolipidemic, antidepressant, and antidiabetic. Interestingly, sprouts contain a high content of saponarin, which showed both anti-inflammatory antioxidant activities. In this study, we evaluated the effect on alcohol-induced liver injury mediated by inflammation oxidative stress. Raw were extracted, quantitative qualitative analyses its components performed. The mice fed liquid alcohol diet with or...
Previous studies demonstrated effects of green tea on weight loss; however, tea-induced modulation adipocyte function is not fully understood. Here, we investigated the major phytochemical, epigallocatechin-3-gallate (EGCG) triglyceride contents, lipolysis, mitochondrial function, and autophagy, in adipocytes differentiated from C3H10T1/2 cells immortalized pre-adipocytes vitro. EGCG reduced triglycerol content significantly by 25%, comparable to nutrient starvation state. did affect protein...
Higher susceptibility to metabolic disease in male exemplifies the importance of sexual dimorphism pathogenesis. We hypothesized that higher incidence non-alcoholic fatty liver males involves sex-specific interactions between and adipose tissue. In present study, we used a methionine-choline deficient (MCD) diet-induced mouse model investigate sex differences response After 2 weeks on an MCD-diet, was induced manner, affecting mice more severely than females. The MCD-diet increased lipolytic...
Transient inflammation in adipose tissue triggers Jak-TGFβ signaling to promote beige adipocyte differentiation.
Myricetin is a biologically active natural polyphenol with beneficial effects on metabolic health. This study aimed to examine the of myricetin expression levels genes involved in lipolysis and mitochondrial respiration adipocytes anti-obesity potential myricetin. The results indicated that reduced triglyceride (TG) content increased oxygen consumption rate (OCR) vitro. To determine effect myricetin, C57BL6/J mice were fed high-fat diet (HFD) for eight weeks then treated (10 mg/kg) 2 weeks....
15-lipoxygenase is involved in the generation of specialized pro-resolving lipid mediators that play essential roles resolution and inflammatory responses. Here, we investigated anti-inflammatory role Alox15 skin homeostasis. We demonstrated knockout (KO) led to hair loss disrupted structural integrity dorsal skin. KO resulted follicle stem cells abnormal transition dermal adipocytes into fibroblasts. deficiency increased infiltration proinflammatory macrophages upregulated necroptotic...
We previously showed that barley sprout extract (BSE) prevents chronic alcohol intake-induced liver injury in mice. BSE notably inhibited glutathione (GSH) depletion and increased inflammatory responses, revealing its mechanism of preventing alcohol-induced injury. In the present study we investigated whether antioxidant effect involves enhancing nuclear factor-erythroid 2 related factor (Nrf2) activity GSH synthesis to inhibit oxidative Mice fed for four weeks exhibited significantly...
To retrospectively evaluate the outcome and toxicity of total lymphoid irradiation (TLI) based conditioning regimen for allogeneic hematopoietic stem cell transplantation (HSCT) in severe aplastic anemia (SAA) patients who experienced an engraftment failure from prior HSCT or were heavily transfused.Between 1995 2006, 20 SAA received TLI HSCT. All multi-transfused had long duration disease. Fifteen (75%) graft In 18 (90%) patients, donors human leukocyte antigen identical siblings. The...
Polycyclic aromatic hydrocarbons (PAHs) are widespread contaminants resulting from the incomplete combustion of organic materials in environment. The primary concern for hazardous effect PAHs is their ability to activate pathway linked aryl hydrocarbon receptor (AhR) and lead carcinogenesis. While previous research has demonstrated that oxidative stress plays a key role AhR-dependent toxic response, on biosynthesis glutathione (GSH), which powerful endogenous antioxidant, not been...
Aging-related adipose tissue dysfunction contributes to the progression of chronic metabolic diseases. We investigated role age-dependent expression a neurotrophin, brain-derived neurotrophic factor (BDNF) in tissue. Pro-BDNF was elevated epididymal white (eWAT) with advanced age, which associated reduction sympathetic innervation. Interestingly, BDNF enriched PDGFRα+ adipocyte progenitors isolated from eWAT, increase expression. In vitro pro-BDNF treatment caused apoptosis adipocytes...