A5100329206- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Electrochemical sensors and biosensors
- Advanced biosensing and bioanalysis techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- Conducting polymers and applications
- Effects and risks of endocrine disrupting chemicals
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Genetics, Aging, and Longevity in Model Organisms
- Nerve injury and regeneration
- Plasmonic and Surface Plasmon Research
- Quantum Dots Synthesis And Properties
- Alzheimer's disease research and treatments
- Electrochemical Analysis and Applications
- Parkinson's Disease Mechanisms and Treatments
- Autophagy in Disease and Therapy
- Pluripotent Stem Cells Research
- Biochemical effects in animals
- Advanced Glycation End Products research
- Neuroscience and Neuropharmacology Research
- Vitamin C and Antioxidants Research
- Genomics, phytochemicals, and oxidative stress
- Neurological Disease Mechanisms and Treatments
- Advanced Nanomaterials in Catalysis
Pusan National University
2016-2025
Sungkyunkwan University
2014-2025
Korea University
2011-2024
Pacific Northwest National Laboratory
2018-2024
Gachon University
2022-2024
University of Missouri
2019-2024
Seoul National University Hospital
2009-2024
Yonsei University
2009-2024
Busan Institute of Science and Technology
2024
Daegu Fatima Hospital
2024
To determine the role of brain-derived neurotrophic factor (BDNF) in enhancement hippocampal neurogenesis resulting from dietary restriction (DR), heterozygous BDNF knockout (BDNF +/-) mice and wild-type were maintained for 3 months on DR or ad libitum (AL) diets. Mice then injected with bromodeoxyuridine (BrdU) killed either 1 day 4 weeks later. Levels protein neurons throughout hippocampus decreased +/- mice, but increased by to a lesser amount mice. One after BrdU injection number...
Recent epidemiological and clinical data suggest that persons with low folic acid levels elevated homocysteine are at increased risk of Alzheimer's disease (AD), but the underlying mechanism is unknown. We tested hypothesis impaired one-carbon metabolism resulting from deficiency high promotes accumulation DNA damage sensitizes neurons to amyloid beta-peptide (Abeta) toxicity. Incubation hippocampal cultures in acid-deficient medium or presence methotrexate (an inhibitor metabolism) induced...
The adult brain contains small populations of neural precursor cells (NPC) that can give rise to new neurons and glia, may play important roles in learning memory, recovery from injury. Growth factors influence the proliferation, differentiation survival NPC, mediate responses NPC injury environmental stimuli such as enriched environments physical activity. We now report neurotrophin expression neurogenesis be modified by a change diet. When mice are maintained on dietary restriction (DR)...
Curcumin is a natural phenolic component of yellow curry spice, which used in some cultures for the treatment diseases associated with oxidative stress and inflammation. has been reported to be capable preventing death neurons animal models neurodegenerative disorders, but its possible effects on developmental adult neuroplasticity are unknown. In present study, we investigated curcumin mouse multi-potent neural progenitor cells (NPC) hippocampal neurogenesis. exerted biphasic cultured NPC;...
Background. Colistin, originally abandoned due to high rates of nephrotoxicity, has been recently reintroduced activity against carbapenem-resistant Gram-negative organisms. Recent literature, largely obtained from outside the United States, suggests a lower rate nephrotoxicity than historically reported.
Finding the fivefold path Crystals formed in nature or synthesized a lab can have domains with different orientations that are called twins. Having five of these is relatively common, but how twins form still mystery. Song et al. combined situ transmission electron microscope observations simulations to find two pathways for forming gold, platinum, and palladium nanoparticles. This combination provides key insight into twin-forming process, which might be exploited developing nanoparticles...
Abstract Research on the relationship between perceived organizational support (POS) and affective commitment (AC) has primarily adopted a social exchange perspective. In this study we considered complementary socio‐emotional explanations of POS–AC relationship. We focused mediating role organization‐based self‐esteem (OBSE) tested competing models POS–OBSE‐AC separately data from two Korean banks that experienced different levels downsizing following 1997 financial crisis. further extended...
Wnt/beta-catenin signaling plays a central role in development and is also involved diverse array of diseases. Binding Wnts to the coreceptors Frizzled LRP6/5 leads phosphorylation PPPSPxS motifs intracellular region inhibition GSK3beta bound scaffold protein Axin. However, it remains unknown how specifically inhibited upon Wnt stimulation. Here, we show that overexpression LRP6 containing Ser/Thr rich cluster motif impairs activity cells. Synthetic peptides strongly inhibit vitro only when...
Hypoalbuminemia may increase the risk of acute kidney injury (AKI). The authors investigated whether immediate preoperative administration 20% albumin solution affects incidence AKI after off-pump coronary artery bypass surgery.In this prospective, single-center, randomized, parallel-arm double-blind trial, 220 patients with serum levels less than 4.0 g/dl were administered 100, 200, or 300 ml human according to level (3.5 3.9, 3.0 3.4, g/dl, respectively) an equal volume saline before...
Near-infrared-light-sensitive multifunctional smart drug-loaded polymer gold nanoshells are fabricated as advanced prototypes, composed of chemotherapeutic agents (therapeutic antibody and anticancer polymeric nanoparticles) for systemic chemotherapy human epithelial cancer a polymer-based nanoshell localized photothermal treatment by NIR light.
We have shown previously that withaferin A (WA), a promising anticancer constituent of Ayurvedic medicine plant Withania somnifera, inhibits growth human breast cancer cells in culture and vivo association with apoptosis induction. The present study builds on these observations demonstrates WA constitutive as well interleukin-6 (IL-6)-inducible activation signal transducer activator transcription 3 (STAT3), which is an oncogenic factor activated many malignancies including cancer. treatment...
Sirtuins (SIRTs), NAD+-dependent class III histone deacetylases (HDACs), play an important role in the regulation of cell division, survival and senescence. Although a number effective SIRT inhibitors have been developed, little is known about specific mechanisms their anticancer activity. In this study, we investigated effects sirtinol, inhibitor, on MCF-7 human breast cancer cells. Apoptotic autophagic death were measured. Sirtinol significantly inhibited proliferation cells...
Objective: Tamoxifen is currently used for the treatment of estrogen receptor-positive breast cancer patients, but acquired resistance to tamoxifen a critical problem in therapy.Suberoylanilide hydroxamic acid (SAHA) prototype newly developed HDAC inhibitor.The aim this study investigate anticancer effects SAHA tamoxifen-resistant MCF-7 (TAMR/MCF-7) cells.Methods: Cytotoxicity, apoptosis and autophagic cell death induced by were studied.A TAMR/MCF-7 cells xenograft model was established...
In Parkinson's disease (PD), neuroinflammation plays a critical role in the neurodegenerative process. Furthermore, activated microglia and astrocytes, responsible for immune response central nervous system, are found regions associated with dopaminergic neuronal death. The flavonoid baicalein is known to have antibacterial, antiviral, antiinflammatory activities. present study, neuroprotective effects of were examined murine 1‐methyl‐4‐phenyl‐1,2,3,4‐tetrahydropyridine (MPTP) model PD. Low...
Keywords: colon-specific delivery, dual-sensitive budesonide, inflammatory bowel disease