Dina Tiniakos
A5057740723- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Alcohol Consumption and Health Effects
- Hepatitis C virus research
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Liver physiology and pathology
- Endoplasmic Reticulum Stress and Disease
- Pancreatic function and diabetes
- Lipid metabolism and disorders
- Cancer-related Molecular Pathways
- HER2/EGFR in Cancer Research
- Diabetes and associated disorders
- Organ Transplantation Techniques and Outcomes
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Fibroblast Growth Factor Research
- Immune Cell Function and Interaction
- Metabolism, Diabetes, and Cancer
- Drug-Induced Hepatotoxicity and Protection
Newcastle University
2016-2025
Aretaeio Hospital
2020-2025
National and Kapodistrian University of Athens
2015-2024
NIHR Newcastle Biomedical Research Centre
2021-2024
Clinical Research Institute
2023-2024
Newcastle upon Tyne Hospital
2016-2023
Newcastle upon Tyne Hospitals NHS Foundation Trust
2015-2021
Freeman Hospital
2016-2018
Royal Victoria Infirmary
1995-2017
Chinese University of Hong Kong
2017
Abstract Hepatocellular carcinoma (HCC) can have viral or non-viral causes 1–5 . Non-alcoholic steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved for treating HCC, but biomarker-based stratification patients optimal response to therapy unmet need 6,7 Here we report the progressive accumulation exhausted, unconventionally activated CD8 + PD1 T cells in NASH-affected livers. In preclinical models NASH-induced therapeutic immunotherapy targeted at programmed...
Abstract The incidence of non-alcoholic fatty liver disease (NAFLD) increases with age. Cellular senescence refers to a state irreversible cell-cycle arrest combined the secretion proinflammatory cytokines and mitochondrial dysfunction. Senescent cells contribute age-related tissue degeneration. Here we show that accumulation senescent promotes hepatic fat steatosis. We report close correlation between markers hepatocyte senescence. elimination by suicide gene-meditated ablation p16 Ink4a...
Non-invasive fibrosis scores are widely used to identify/exclude advanced in patients with non-alcoholic fatty liver disease (NAFLD). However, these were principally developed and validated aged between 35 65 years of age. The objective this study was assess the effect age on performance non-invasive tests NAFLD.Patients recruited from European specialist hepatology clinics. cohort divided into five age-based groups: ≤35 (n=74), 36-45 (n=96), 46-55 (n=197), 56-64 (n=191), ≥65 (n=76),...
Abstract Non-alcoholic fatty liver disease (NAFLD) is an increasingly common condition, strongly associated with the metabolic syndrome, that can lead to progressive hepatic fibrosis, cirrhosis and failure. Subtle inter-patient genetic variation environmental factors combine determine in progression. A non-synonymous polymorphism TM6SF2 (rs58542926 c.449 C>T, p.Glu167Lys) was recently increased triglyceride content, but whether this variant promotes clinically relevant fibrosis unknown....
•Genome-wide association study involved 1,483 biopsied NAFLD cases and 17,781 controls.•Main analysis shows genome-wide significance for PNPLA3, TM6SF2, HSD17B13 GCKR.•Sub-analyses show near LEPR NASH PYGO1 steatosis.•Except GCKR, the significant signals were replicated. Background & AimsGenetic factors associated with non-alcoholic fatty liver disease (NAFLD) remain incompletely understood. To date, most studies (GWASs) have adopted radiologically assessed hepatic triglyceride content as...
A 25-gene expression signature associates with progression of fibrosing steatohepatitis in independent NAFLD cohorts.
Primary biliary cholangitis (formerly known as primary cirrhosis, PBC) is an autoimmune liver disease in which a cycle of immune mediated epithelial cell injury, cholestasis and progressive fibrosis can culminate over time end-stage cirrhosis. Both genetic environmental influences are presumed relevant to initiation. PBC most prevalent women those the age 50, but spectrum recognised adult patients globally; male sex, younger at onset (<45) advanced presentation baseline predictors poorer...
Liver biopsy is currently the most reliable way of evaluating liver fibrosis in patients with non-alcoholic fatty disease (NAFLD). Its inherent risks limit its widespread use. Differential DNA methylation peroxisome proliferator-activated receptor gamma (PPARγ) gene promoter has recently been shown to stratify terms severity but requires access tissue. The aim this study was assess whether circulating could be detected human plasma and potentially used NAFLD.Patients biopsy-proven NAFLD...
Background & AimsPharmacologic treatments for nonalcoholic steatohepatitis (NASH) are limited. Lifestyle interventions believed to be effective in reducing features of NASH, although the effect regular exercise, independent dietary change, is unclear. We performed a randomized controlled trial study exercise on hepatic triglyceride content (HTGC) and biomarkers fibrosis patients with NASH.MethodsTwenty-four (mean age, 52 ± 14 y; body mass index, 33 6 kg/m2) sedentary lifestyles (<60 min/wk...
Objective The full phenotypic expression of non-alcoholic fatty liver disease (NAFLD) in lean subjects is incompletely characterised. We aimed to investigate prevalence, characteristics and long-term prognosis Caucasian with NAFLD. Design study cohort comprises 1339 biopsy-proven NAFLD from four countries (Italy, UK, Spain Australia), stratified into non-lean (body mass index (BMI) </≥25 kg/m 2 ). Liver/non-liver-related events survival free transplantation were recorded during the...
•Hepatocyte ballooning identification underpins regulatory-approved drug efficacy endpoints in clinical trials.•We report substantial variation ballooned cell by expert hepatopathologists.•Our data suggest that is too subjective for its presence or complete absence to be used as a trial endpoint.•A ‘concordance atlas’ of cells identified multiple pathologists can train AI-based image analysis.•AI-based approaches may provide more reliable way assess the range injury recorded hepatocyte...
Abstract Background & Aims Diagnostic histological criteria for autoimmune hepatitis (AIH) have not been clearly established. Previously published focused mainly on chronic AIH, in which inflammatory changes occur portal/periportal regions and may be applicable to acute presentation of are typically predominantly lobular location. International consensus the diagnosis assessment disease severity both AIH thus urgently needed. Methods Seventeen expert liver pathologists convened at an...
Abstract Non-alcoholic fatty liver disease (NAFLD) is a common, progressive strongly associated with the metabolic syndrome. It unclear how progression of NAFLD towards cirrhosis translates into systematic changes in circulating proteins. Here, we provide detailed proteo-transcriptomic map steatohepatitis and fibrosis during NAFLD. In this multicentre proteomic study, characterize 4,730 proteins 306 patients histologically characterized integrate transcriptomic analysis paired tissue. We...
Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty disease, encompasses steatosis and metabolic steatohepatitis (MASH), leading to cirrhosis hepatocellular carcinoma. Preclinical MASLD research is mainly performed in rodents; however, the model that best recapitulates human yet be defined. We conducted a wide-ranging retrospective review (metabolic phenotype, histopathology, transcriptome benchmarked against humans) of murine...
Objective Hyperferritinaemia is associated with liver fibrosis severity in patients metabolic dysfunction-associated steatotic disease (MASLD), but the longitudinal implications have not been thoroughly investigated. We assessed role of serum ferritin predicting long-term outcomes or death. Design evaluated relationship between baseline and events a multicentre cohort 1342 patients. Four survival models considering confounders non-invasive scoring systems were applied repeated five-fold...