A5056967218- Liver Disease Diagnosis and Treatment
- Psoriasis: Treatment and Pathogenesis
- Endoplasmic Reticulum Stress and Disease
- Immune Cell Function and Interaction
- Whipple's Disease and Interleukins
- Immune responses and vaccinations
- Galectins and Cancer Biology
- Prostate Cancer Treatment and Research
- Digestive system and related health
- Liver Disease and Transplantation
- Tryptophan and brain disorders
- Cholesterol and Lipid Metabolism
- Dietary Effects on Health
- Reproductive System and Pregnancy
- Infant Nutrition and Health
- Pancreatic function and diabetes
- Gut microbiota and health
- Dermatology and Skin Diseases
- CRISPR and Genetic Engineering
- Genetics, Aging, and Longevity in Model Organisms
- Inflammasome and immune disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Regulation of Appetite and Obesity
- Glycosylation and Glycoproteins Research
- Cancer Immunotherapy and Biomarkers
National Institute of Allergy and Infectious Diseases
2023-2025
National Institutes of Health
2024-2025
Spanish National Cancer Research Centre
2016-2024
Cornell University
2023
Weill Cornell Medicine
2023
Princeton University
2023
Abstract Hepatocellular carcinoma (HCC) can have viral or non-viral causes 1–5 . Non-alcoholic steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved for treating HCC, but biomarker-based stratification patients optimal response to therapy unmet need 6,7 Here we report the progressive accumulation exhausted, unconventionally activated CD8 + PD1 T cells in NASH-affected livers. In preclinical models NASH-induced therapeutic immunotherapy targeted at programmed...
Hepatocellular carcinoma (HCC) is an aggressive primary liver cancer. However, its origin remains a debated question. Using human data and various hepatocarcinogenesis mouse models, we show that, in early stages, transformed hepatocytes, independent of their proliferation status, activate hepatic progenitor cell (HPC) expansion. Genetic lineage tracing HPCs hepatocytes reveals all HCC originates from hepatocytes. whereas models tumors do not emanate HPCs, tracking progenitors model mimicking...
Mild or transient dietary restriction (DR) improves many aspects of health and aging. Emerging evidence from us others has demonstrated that DR also optimizes the development quality immune responses. However, factors mechanisms involved remain to be elucidated. Here, we propose DR-induced optimization immunological memory requires a complex cascade events involving T cells, intestinal microbiota, myeloid cells. Our findings suggest enhances ability cells recruit activate in context...
Enteroviruses are suspected to contribute insulin-producing β cell loss and hyperglycemia-induced diabetes. However, mechanisms not fully defined. Here, we show that coxsackievirus B type 4 (CVB4) infection in human islet-engrafted mice rat insulinoma cells displays of unconventional prefoldin RPB5 interactor (URI) PDX1, affecting function identity. Genetic URI ablation the mouse pancreas causes PDX1 depletion cells. Importantly, diabetic heterozygous overexpressing more glucose tolerant....
Overeating leads to obesity, a low-grade inflammatory condition involving interleukin-17A (IL-17A). While pro-opiomelanocortin (POMC) neurons regulate feeding, their connection with IL-17A is not well understood. To impair signaling in POMC neurons, receptor (
Abstract Maintenance of tissue integrity is a requirement host survival. This mandate prime importance at barrier sites that are constitutively exposed to the environment. Here, we show exposure skin non-inflammatory xenobiotics promotes repair; more specifically, mild detergent reactivation defined retroelements leading induction retroelement-specific CD8 + T cells. These cell responses Langerhans dependent and establish residency within skin. Upon injury, cells significantly accelerate...
Abstract Bone is the most common site of breast cancer (BC) metastasis, occurring in 70% patients, and an indication short-term prognosis. Understanding environmental host factors involved induction metastasis essential to develop therapies that extend patient’s lifespan. colonization by cells a stepwise process relies on interactions between comprise bone microenvironment, such as osteoclasts, osteoblasts, hematopoietic cells, immune adipocytes. Calcium, growth factors, chemokines...